Results 151 to 160 of about 425,330 (380)

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

GxxxG Motifs, Phenylalanine, and Cholesterol Guide the Self-Association of Transmembrane Domains of ErbB2 Receptors [PDF]

, 2011
Anupam Prakash, Lorant Janosi, Manolis Doxastakis   +2 more
openalex   +1 more source

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

The essential tyrosine‐containing loop conformation and the role of the C‐terminal multi‐helix region in eukaryotic phenylalanine ammonia‐lyases [PDF]

, 2006
Sarolta Pilbák, Anna Tomin, János Rétey, László Poppe   +3 more
openalex   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Transcriptomics and Metabolomics Reveal Biosynthetic Pathways and Regulatory Mechanisms of Phenylpropanes in Different Ploidy of Capsicum frutescens

Plants
Pepper is a significant cash crop, and Capsicum frutescens is an exemplary variety of pepper cultivated for its distinctive flavor and substantial nutritional value.
Yinxin Yang, Qihang Cai, Yanbo Yang, Xuan Wang, Liping Li, Zhenghai Sun, Weiwei Li   +6 more
doaj   +1 more source

Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor [PDF]

, 2011
Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the ...
Ashby, Jamie A., Dougherty, Dennis A., Lummis, Sarah C. R., McGonigle, Ian   +3 more
core  

HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity

Advanced Science, EarlyView.
HTGTS‐TCR‐seq is an efficient and cost‐effective method for profiling TCRα and TCRβ rearrangements using only a few primers. It captures both productive and nonproductive recombination events, minimizes primer bias, and reveals stage‐specific and age‐related repertoire changes in mice, as well as conserved features in human peripheral T cells ...
Rui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu, Hai‐Qiang Dai   +9 more
wiley   +1 more source

Effect of large neutral amino acids treatment on blood phenylalanine, tyrosine, and tryptophan levels in adolescent and young adult PKU patients

Trends in Pediatrics
Objective: We aimed to evaluate the change in phenylalanine (Phe), Tyrosine (Tyr), and Tryptophan (Trp) blood levels in classical PKU patients treated with large neutral amino acids (LNAA) supplementation.
Fehime Erdem, Ebru Canda, Havva Yazıcı, Yasemin Atik Altınok, Merve Yoldaş Çelik, Ayşe Yüksel Yanbolu, Sema Kalkan Uçar, Sara Habif, Mahmut Çoker   +8 more
doaj   +1 more source

Secondary water pore formation for proton transport in a ClC exchanger revealed by an atomistic molecular dynamics simulation [PDF]

, 2008
Several prokaryotic ClC proteins have been demonstrated to function as exchangers that transport both chloride ions and protons simultaneously in opposite directions.
Won Ho Jo, Youn Jo Ko
core   +1 more source