Results 191 to 200 of about 425,330 (380)
AI‐Enhanced Surface‐Enhanced Raman Scattering for Accurate and Sensitive Biomedical Sensing
AI‐SERS advances spectral interpretation with greater precision and speed, enhancing molecular detection, biomedical analysis, and imaging. This review explores its essential contributions to biofluid analysis, disease identification, therapeutic agent evaluation, and high‐resolution biomedical imaging, aiding diagnostic decision‐making.
Seungki Lee, Rowoon Park, Ho Sang Jung
wiley +1 more source
Purification and properties of phenylalanine ammonia-lyase from plant tissue cultures [PDF]
M Dhandapani, Asok Antony, P. Sriramarao
openalex +1 more source
This study reveals that sampling strategy (i.e., sampling size and approach) is a foundational prerequisite for building accurate and generalizable AI models in peptide discovery. Reaching a threshold of 7.5% of the total tetrapeptide sequence space was essential to ensure reliable predictions.
Meiru Yan +3 more
wiley +1 more source
Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides
A flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Yue Zhang +3 more
wiley +2 more sources
Diversity and conservation of interactions for binding heme in b-type heme proteins [PDF]
Marles-Wright, Jon +3 more
core +1 more source
Ko‐Assemblierungen regulieren die katalytische Aktivität von Peptidfibrillen
Katalytische selbstassemblierende Peptide (kSAPs) bilden Fibrillen, die die Retro‐Aldol‐Reaktion von Methodol katalysieren. Die Ko‐Assemblierung mit inaktiven Peptiden reguliert die katalytische Aktivität, indem sie die Zugänglichkeit des Substrats und den Abstand zum nukleophilen Lysin verändert.
Albin Lahu +10 more
wiley +1 more source
Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee +4 more
wiley +2 more sources
Separation of DL-Phenylalanine by Chiral Selector‐Supported Ultrafiltration
Sema Salgın +2 more
openalex +1 more source

