Results 191 to 200 of about 155,562 (237)

Bioactivity Profiles of Progressively Ring‐Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto‐Piperazines as Antitrypanosome Agents

ChemBioChem, EarlyView.
All‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
Mengfan He, Christina M. Thomson, Dawn Thompson, Vytautus Kuodis, Terry K. Smith, Sergio Dall’Angelo, David O’Hagan   +6 more
wiley   +1 more source

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

Enhancing Antigen Recognition of Living Cells by Site‐Specific VHH Antibody Conjugation

ChemBioChem, EarlyView.
Site‐specific incorporation of azido‐phenylalanine (AzF) into antibodies enables precise conjugation, allowing anti‐mCherry variable domains of heavy‐chain‐only antibodies (VHHs) to be aligned and immobilized on dibenzylcyclooctyne (DBCO)‐coated glass via click chemistry.
Chengyuan Zhu, Yudai Ichikawa, Fumiyoshi Yamashita, Yuriko Higuchi   +3 more
wiley   +1 more source

Structural and Spectroscopic Insights into Catalytic Intermediates of a [NiFe]‐hydrogenase from Group 3

ChemBioChem, EarlyView.
Hydrogenases catalyze reversible H2 production and are potential models for renewable energy catalysts. Here, the full redox landscape of a group 3 [NiFe]‐hydrogenase from methanothermococcus thermolithotrophicus is elucidated, resembling group 1 enzymes.
Marion Jespersen, Christian Lorent, Olivier N. Lemaire, Ingo Zebger, Tristan Wagner   +4 more
wiley   +1 more source

Synthesis and antimicrobial activity of a series of optically active quaternary ammonium salts derived from phenylalanine

Open Chemistry, 2010
Lukáč Miloš, Lacko Ivan, Bukovský Marián, Kyselová Zuzana, Karlovská Janka, Horváth Branislav, Devínsky Ferdinand   +6 more
doaj   +1 more source

Effect of Genotype on the Properties of Flours and Protein Isolates Derived From Wrinkled and Round Peas

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives This study evaluated the effect of seed shape on the composition, functional, and quality properties of pea flours and protein isolates. Wrinkled‐seed (WPAs) and round‐seed (RPA) pea accessions were selected from a genome‐wide association study panel.
Cassia Galves, Krishna Kishore Gali, Thomas D. Warkentin, James House, Michael Nickerson   +4 more
wiley   +1 more source

Sequence‐Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

ChemistryEurope, EarlyView.
Two oppositely charged intrinsically disordered peptides (IDPs) coassemble into heterotypic nanofibers. Homochiral mixtures (L/L IDPs) form homogeneous, aligned bundles with the more positive IDP. Heterochiral mixtures (L/D IDPs) yield heterogeneous, twisted bundles as positive‐IDP content increases.
Yuchen Qiao, Matthew Chu, Grace Wu, Zhiyu Liu, Bing Xu   +4 more
wiley   +1 more source

Remote Conformational Control of a Chloride‐Binding Site

ChemistryEurope, EarlyView.
Chloride‐binding foldamers have been developed that have stereogenic C‐ and N‐terminal groups separated by a helical α‐aminoisobutyric acid (Aib) body. Chloride affinity is sensitive to the sense and strength of screw‐sense induction by each N‐terminal residue.
Rhodri Ll. Evans, Luis Martínez‐Crespo, Benedicte Doerner, Rosa M. Gomila, George F. S. Whitehead, Antonio Frontera, Simon J. Webb   +6 more
wiley   +1 more source

Synthesis of α‐Pentafluorosulfanylated‐β2,3‐Amino Esters

ChemistryEurope, EarlyView.
De novo α‐SF5‐β2,3‐amino esters are now accessible through a straightforward aza‐Michael reaction using a series of newly developed (E)‐α‐SF5‐α,β‐unsaturated esters. Two new, highly functionalized, contiguous tertiary stereocenters are formed with diastereodivergence governed by the choice of solvent and/or base.
Thi Mo Nguyen, Guilhem Colomer, Oscar Maugue‐Sauze, Nicolas Blanchard, Vincent Bizet, Dominique Cahard   +5 more
wiley   +1 more source

THE ENZYMATIC CONVERSION OF PHENYLALANINE TO TYROSINE

Journal of Biological Chemistry, 1957
openaire   +5 more sources