Results 191 to 200 of about 425,330 (380)

AI‐Enhanced Surface‐Enhanced Raman Scattering for Accurate and Sensitive Biomedical Sensing

open access: yesAdvanced Intelligent Discovery, EarlyView.
AI‐SERS advances spectral interpretation with greater precision and speed, enhancing molecular detection, biomedical analysis, and imaging. This review explores its essential contributions to biofluid analysis, disease identification, therapeutic agent evaluation, and high‐resolution biomedical imaging, aiding diagnostic decision‐making.
Seungki Lee, Rowoon Park, Ho Sang Jung
wiley   +1 more source

Sampling Strategy: An Overlooked Factor Affecting Artificial Intelligence Prediction Accuracy of Peptides’ Physicochemical Properties

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study reveals that sampling strategy (i.e., sampling size and approach) is a foundational prerequisite for building accurate and generalizable AI models in peptide discovery. Reaching a threshold of 7.5% of the total tetrapeptide sequence space was essential to ensure reliable predictions.
Meiru Yan   +3 more
wiley   +1 more source

Ribosomal Synthesis of Topologically Defined Thioisoindole‐Bridged Bicyclic Peptides

open access: yesAngewandte Chemie, EarlyView.
A flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Yue Zhang   +3 more
wiley   +2 more sources

Diversity and conservation of interactions for binding heme in b-type heme proteins [PDF]

open access: yes, 2007
Marles-Wright, Jon   +3 more
core   +1 more source

Ko‐Assemblierungen regulieren die katalytische Aktivität von Peptidfibrillen

open access: yesAngewandte Chemie, EarlyView.
Katalytische selbstassemblierende Peptide (kSAPs) bilden Fibrillen, die die Retro‐Aldol‐Reaktion von Methodol katalysieren. Die Ko‐Assemblierung mit inaktiven Peptiden reguliert die katalytische Aktivität, indem sie die Zugänglichkeit des Substrats und den Abstand zum nukleophilen Lysin verändert.
Albin Lahu   +10 more
wiley   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

open access: yesAngewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee   +4 more
wiley   +2 more sources

Separation of DL-Phenylalanine by Chiral Selector‐Supported Ultrafiltration

open access: diamond, 2019
Sema Salgın   +2 more
openalex   +1 more source

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