Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Regulatory mechanisms of amino acid metabolic pathways in Rhododendron chrysanthum Pall. Under UV-B stress. [PDF]
Lyu J, Li X, Yu W, Zhou X, Xu H, Zhou X.
europepmc +1 more source
A phosphorescent iridium(III) complex has been prepared with a 6‐hydrazinonicotinic acid (HYNIC) ligand tethered to a lysine‐ureido‐glutamatic acid pharmacophore, which binds to an enzyme, called prostate‐specific membrane antigen (PSMA), which is overexpressed in prostate cancer.
La'El Kimchi +6 more
wiley +1 more source
Transcriptome Analysis Coupled with Metabolome Profiling at a Key Time Point Reveals the Molecular Mechanism of Cold Stress Response in Oil Palm (<i>Elaeis guineensis</i> Jacq.). [PDF]
Wu Q +5 more
europepmc +1 more source
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi +3 more
wiley +1 more source
Meat quality and metabolism alterations in broiler driven by selective breeding and their associations with gut microbiota. [PDF]
Xu L +8 more
europepmc +1 more source
Design of Fuel‐Dependent, Complex‐Coacervate‐Based Synthetic Cells
Fuel‐dependent synthetic cells form and persist only in the presence of chemical fuel, decaying under starvation. We establish design rules for hexapeptide‐based coacervates, showing that tryptophan enhances polyanion binding, extends lifetime, and reduces waste sensitivity.
Anna‐Lena Holtmannspötter +9 more
wiley +1 more source
Two adult sisters with untreated phenylketonuria: Strikingly discordant clinical phenotype. [PDF]
Demirbas D +6 more
europepmc +1 more source
Flipping the Card With Enantiodivergent Organocatalysis
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre +3 more
wiley +1 more source
Amino acids: Missing link in preeclampsia pathogenesis? [PDF]
Gezer IS +7 more
europepmc +1 more source

