Results 51 to 60 of about 359,480 (360)

Occurrence of the Leucine-to-Phenylalanine knockdown Resistance (kdr) Mutation in Anopheles Arabiensis Populations in Tanzania, Detected by a Simplified High-Throughput SSOP-ELISA Method. [PDF]

, 2006
Molecular markers of insecticide resistance can provide sensitive indicators of resistance development in malaria vector populations. Monitoring of insecticide resistance in vector populations is an important component of current malaria control ...
Alifrangis, Michael, Drakeley, Chris, Kulkarni, Manisha A, Kweka, Eliningaya, Lyimo, Issa, Magesa, Stephen, Malima, Robert, Matowo, Johnson, Mosha, Frank W, Peter, Justin, Rau, Manfred E, Rowland, Mark, Salanti, Ali   +12 more
core   +3 more sources

Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators

RSC Adv., 2014
Herein we report the discovery of new modulators of human phenylalanine hydroxylase (hPAH) inspired by the structure of its substrate and regulatorl-phenylalanine.
Francesco Montalbano, João Leandro, Gonçalo D. V. F. Farias, Paulo R. Lino, Rita C. Guedes, João B. Vicente, Paula Leandro, Pedro M. P. Gois   +7 more
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

STIMULATION OF GROWTH AND OIL PRODUCTION IN CUMIN PLANT [PDF]

Scientific Journal of Flowers and Ornamental Plants, 2020
A pot experiment was carried out during two successive seasons (2017/ 2018 and 2018/2019) at Medicinal and Aromatic Plants Research Department in Dokki. The aim of this work was to study the effect of foliar application of phenylalanine (Phe) and p < /em>
Hanan Ali, Hala Mohammed
doaj   +1 more source

Detachment of semiflexible polymer chains from a substrate - a Molecular Dynamics investigation

, 2014
Using Molecular Dynamics simulations, we study the force-induced detachment of a coarse-grained model polymer chain from an adhesive substrate. One of the chain ends is thereby pulled at constant speed off the attractive substrate and the resulting saw ...
Erbas, A., Milchev, A., Paturej, J., Rostiashvili, V. G.   +3 more
core   +1 more source

Mechanism of phenylalanine regulation of phenylalanine hydroxylase.

Journal of Biological Chemistry, 1990
The mechanism of phenylalanine regulation of rat liver phenylalanine hydroxylase was studied. We show that phenylalanine "activates" phenylalanine hydroxylase, converting it from an inactive to active form, by binding at a true allosteric regulatory site.
R, Shiman, S H, Jones, D W, Gray
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Phenylalanine and Tyrosine as Exogenous Precursors of Wheat (Triticum aestivum L.) Secondary Metabolism through PAL-Associated Pathways

Plants, 2020
Reacting to environmental exposure, most higher plants activate secondary metabolic pathways, such as the metabolism of phenylpropanoids. This pathway results in the formation of lignin, one of the most important polymers of the plant cell, as well as a ...
Pavel Feduraev, Liubov Skrypnik, Anastasiia Riabova, Artem Pungin, Elina Tokupova, Pavel Maslennikov, Galina Chupakhina   +6 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Regulation of the \u3cem\u3eEscherichia coli\u3c/em\u3e Tryptophan Operon by Early Reactions in the Aromatic Pathway [PDF]

, 1970
7-Methyltryptophan (7MT) or compounds which can be metabolized to 7MT, 3-methylanthranilic acid (3MA) and 7-methylindole, cause derepression of the trp operon through feedback inhibition of anthranilate synthetase. Tyrosine reverses 3MA or 7-methylindole
Held, William A., Smith, Oliver H.
core   +1 more source