Results 131 to 140 of about 104,062 (224)

Identification of Phenylalanine 3-Hydroxylase for meta-Tyrosine Biosynthesis

, 2016
Phenylalanine hydroxylase (PheH) is an iron(II)-dependent enzyme that catalyzes the hydroxylation of aromatic amino acid l-phenylalanine (l-Phe) to l-tyrosine (l-Tyr).
Wenjun Zhang (685002), Brian D. Ames (2187694), Christopher T. Walsh (1265718)   +2 more
core   +1 more source

Funktion und Fehlfunktion der Phenylalaninhydroxylase in Abhängigkeit von Genotyp, metabolischem Status und Therapie mit dem pharmakologischen Chaperon Tetrahydrobiopterin [PDF]

, 2012
Staudigl, Michael
core   +1 more source

ALLELIC GENES CODE FOR THE 2 MOLECULAR-WEIGHT FORMS OF RAT PHENYLALANINE-HYDROXYLASE

, 1983
ALLELIC GENES CODE FOR THE 2 MOLECULAR-WEIGHT FORMS OF RAT PHENYLALANINE ...
A GRIMES (14575562), Julian Mercer (13076475), EA HAAN (14575568), IG JENNINGS (14575565), RGH COTTON (14575571)   +4 more
core  

Hydroxylation of Tryptophan by Phenylalanine Hydroxylase

Journal of Biological Chemistry, 1962
J, RENSON, H, WEISSBACH, S, UDENFRIEND
openaire   +2 more sources

CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria. [PDF]

Sci Rep, 2021
Singh K, Cornell CS, Jackson R, Kabiri M, Phipps M, Desai M, Fogle R, Ying X, Anarat-Cappillino G, Geller S, Johnson J, Roberts E, Malley K, Devlin T, DeRiso M, Berthelette P, Zhang YV, Ryan S, Rao S, Thurberg BL, Bangari DS, Kyostio-Moore S.   +21 more
europepmc   +1 more source

Phenylalanine hydroxylase gene haplotypes in Polynesians: Evolutionary origins and absence of alleles associated with severe phenylketonuria

, 1989
Phenylalanine hydroxylase gene haplotypes in Polynesians: Evolutionary origins and absence of alleles associated with severe ...
KNP Mickleson (14576384), HHM Dahl (14574527), Julian Mercer (13076475), K Jahromi (14576378), V Ferguson (14576381), M Hertzberg (13404438), RJ Trent (14576387)   +6 more
core  

Development of a mutation hotspot detection kit for the phenylalanine hydroxylase gene by ARMS-PCR combined with fluorescent probe technology. [PDF]

Biosci Rep, 2021
Qiang R, Wang L, He J, Xu WJ, Li W, Cai N, Wang XB, Zhang R, Zhang LP, Ma XP, Wei C, Song C, Yu W, Wang X, Li X.   +14 more
europepmc   +1 more source

New era in treatment for phenylketonuria: Pharmacologic therapy with sapropterin dihydrochloride

Biologics: Targets & Therapy, 2010
Cary O HardingDepartments of Molecular and Medical Genetics and Pediatrics, Oregon Health & Science University, Portland, Oregon, USAAbstract: Oral administration of sapropterin hydrochloride, recently approved for use by the US Food and Drug ...
Cary O Harding
doaj  

Structural Studies of the Catalytic and Regulatory Mechanisms of Phenylalanine Hydroxylase

, 2011
The catalytic and regulatory mechanisms of phenylalanine hydroxylase were investigated by structural studies of in this research. Phenylalanine hydroxylase (PheH) hydroxylates phenylalanine to produce tyrosine using tetrahydrobiopterin (BH4) and oxygen ...
Li, Jun
core   +1 more source

Mapping the Severity of Phenylalanine Hydroxylase Deficiency. [PDF]

J Inherit Metab Dis
Haitjema S, van Steenis EM, Lubout CMA, Heiner-Fokkema MR, Zschocke J, van Spronsen FJ.   +5 more
europepmc   +1 more source