Results 111 to 120 of about 104,062 (224)

Systematic literature review of the somatic comorbidities experienced by adults with phenylketonuria

Orphanet Journal of Rare Diseases
Background Phenylketonuria (PKU) is an inborn error of phenylalanine (Phe) metabolism that, if untreated, causes Phe accumulation in the brain leading to neurophysiologic alterations and poor outcomes.
Kaleigh B. Whitehall, Sarah Rose, Gillian E. Clague, Kirsten K. Ahring, Deborah A. Bilder, Cary O. Harding, Álvaro Hermida, Anita Inwood, Nicola Longo, François Maillot, Ania C. Muntau, André L. S. Pessoa, Júlio C. Rocha, Fran Rohr, Serap Sivri, Jack Said, Sheun Oshinbolu, Gillian C. Sibbring   +17 more
doaj   +1 more source

Adult human liver mesenchymal progenitor cells express phenylalanine hydroxylase

, 2014
Phenylketonuria (PKU) is one of the most prevalent inherited metabolic diseases and is accountable for a severe encephalopathy by progressive intoxication of the brain by phenylalanine. This results from an ineffective L-phenylalanine hydroxylase enzyme (
Baruteau, Julien, Sokal, Etienne M, Nyabi, Omar, Najimi, Mustapha, Sokal, Etienne, Fauvart, Maarten   +5 more
core   +1 more source

OsASA2 Loss‐of‐Function Confers Broad‐Spectrum Disease Resistance and Triggers Cell Death by Regulating Anthranilate Synthase Activity in Rice

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
Loss of OsASA2 disrupts anthranilate synthase regulation, triggering metabolic reprogramming, cell death and broad‐spectrum disease resistance in rice. ABSTRACT Lesion mimic mutants are valuable for studying plant cell death and defence mechanisms.
Mingliang Guo, Shuyu Jiang, Ying Li, Zhiwei Chen, Shengping Li, Ziqiang Chen, Yuqing Niu, Mo Wang, Songbiao Chen, Dagang Tian   +9 more
wiley   +1 more source

GmERF109 Positively Enhances Soybean Resistance to Phytophthora sojae by Transcriptionally Activating GmG4DT‐Like to Promote Glyceollin I Accumulation

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
GmERF109 is strongly induced in P. sojae‐resistant but not susceptible soybeans. GmERF109 functions as a nuclear AP2/ERF transcription factor, P. sojae directly binding the GCC‐box to activate GmG4DT‐like expression. The GmERF109–GmG4DT‐like module enhances glyceollin I accumulation for soybean resistance to P. sojae.
Xin Fang, Rui Liang, Yiling Cheng, Hong Gao, Chuanzhong Zhang, Jingcan Sun, Junjun Song, Gengpu Zhang, Meng Liu, Yuxin Zhao, Yan Sun, Xiran Wang, Xiaoyu Chen, Kexin Ma, Shuo Wang, Kexin Li, Jiapeng Tong, Junjiang Wu, Pengfei Xu, Shuzhen Zhang   +19 more
wiley   +1 more source

Conventional Phenylketonuria Treatment

Journal of Inborn Errors of Metabolism and Screening, 2016
Phenylketonuria (PKU) is caused by a deficient activity of enzyme phenylalanine (Phe) hydroxylase, which results in high Phe blood concentration, which is toxic to the central nervous system.
Guillén-López Sara MS, RD, López-Mejía Lizbeth Alejandra RD, Ibarra-González Isabel MS, Vela-Amieva Marcela MD   +3 more
doaj   +1 more source

Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase

, 1990
Click on the link to access the article (may not be free).Mutant mice exhibiting heritable hyperphenylalaninemia have been isolated after ethylnitrosourea mutagenesis of the germ line.
Bode, Vernon C., Dove, W. F., Shedlovsky, Alexandra, McDonald, J. David   +3 more
core  

Revisiting the Molecular Roadmap for Sugar Crops: Genome Reading, Trait Writing and Variety Redesigning

Plant Biotechnology Journal, Volume 24, Issue 9, Page 5013-5040, September 2026.
ABSTRACT Sugar crops, including but not limited to sugarcane, sugar beet, sweet sorghum and stevia, are major sources of sugar production in the world. However, conventional breeding approaches, limited by long breeding cycles, low efficiency and restricted capacity to improve complex traits in sugar crops, are increasingly insufficient to address the ...
Peilin Wang, Qibin Wu, Wenzhi Wang, Prakash Lakshmanan, Yangrui Li, Khushi Muhammad, Yuguang Wang, Youxiong Que   +7 more
wiley   +1 more source

The two molecular weight forms of rat phenylalanine hydroxylase are encoded by different messenger RNAs

, 1983
Immunoprecipitation of the phenylalanine hydroxylase formed by translation of rat liver RNA in a rabbit reticulocyte cell-free protein synthesis system was used to examine the origin of the molecular weight heterogeneity of the enzyme.
Julian Mercer (13076475), SM Hunt (14570279), RGH Cotton (14574842)   +2 more
core   +1 more source

Characterization of phenylalanine hydroxylase gene variants and analysis of genotype-phenotype correlation in patients with phenylalanine hydroxylase deficiency from Fujian Province, Southeastern China. [PDF]

Mol Biol Rep, 2022
Zhou J, Zeng Y, Qiu X, Lin Q, Chen W, Luo J, Xu L.   +6 more
europepmc   +1 more source

A phosphatidic acid‐based retrograde signaling pathway responsive to abiotic stress in Arabidopsis

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Due to their sessile nature, plants are constantly exposed to the environment and must cope with sometimes extreme changes in conditions during the day or growing season. Plants depend on photosynthesis as their primary means to generate energy and building blocks, and adverse environmental conditions can stress the photosynthetic apparatus ...
Carrie Hiser, Ron Cook, Yosia Mugume, John E. Froehlich, Christoph Benning   +4 more
wiley   +1 more source