Protein stability and in vivo concentration of missense mutations in phenylalanine hydroxylase
Proteins: Structure, Function, and Bioinformatics, 2012 Zhen Shi, Jenn W. Sellers, J. Moult
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The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability. [PDF]
J Biol Chem, 2019 Khan CA +3 more
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In vitro expression analysis of R68G and R68S mutations in phenylalanine hydroxylase gene.
, 2000 C Zekanowsk +4 more
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Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium. [PDF]
J Biol Chem, 2019 Arturo EC +4 more
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Biochemical and Immunological Characterization of Rat and Human Phenylalanine Hydroxylase
Pteridines, 1991 Petruschka L. +3 more
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Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability. [PDF]
Sci Rep, 2019 Tomé CS +7 more
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Mutagenesis of the regulatory domain of phenylalanine hydroxylase
, 2001 Guoan Wang, Peide Gu, Seymour Kaufman
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Biogenesis of Organelles and Membrane Proteins. [PDF]
, 1988 Harmey, Matthew A. +3 more
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