Results 81 to 90 of about 16,836 (209)

Cell Adhesive Character of Phenylboronic Acid-Modified Insulin and Its Potential as Long-Acting Insulin

Pharmaceuticals, 2019
Phenylboronic acid (PBA) derivatives have attracted substantial attention owing to their unique character of forming dynamic covalent bonds with polyol compounds.
Yui Ohno, Momoko Kawakami, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Yuya Egawa   +5 more
doaj   +1 more source

Practical Spectrophotometric Assay for the \u3cem\u3edapE\u3c/em\u3e-Encoded \u3cem\u3eN\u3c/em\u3e-Succinyl-L,L-Diaminopimelic Acid Desuccinylase, a Potential Antibiotic Target [PDF]

, 2018
A new enzymatic assay for the bacterial enzyme succinyl-diaminopimelate desuccinylase (DapE, E.C. 3.5.1.18) is described. This assay employs N6-methyl-N2-succinyl-L,L-diaminopimelic acid (N6-methyl-L,L-SDAP) as the substrate with ninhydrin used to detect
Ballicora, Miguel A., Becker, Daniel P., Guzman, Estefany R., Heath, Tahirah K., Herbert, Claire A., Holz, Richard C., Lutz, Marlon R., Jr., Nocek, Boguslaw P., Olsen, Kenneth W., Reidl, Cory   +9 more
core   +1 more source

Enhanced catalytic activity of high index faceted palladium nanoparticles in Suzuki-Miyaura coupling due to efficient leaching mechanism [PDF]

, 2014
The structure-property relationship of palladium (Pd) catalysts in Suzuki-Miyaura cross-coupling reactions was investigated using Pd nanocrystals of uniform size and shape.
Collins, Gillian, Holmes, Justin D., McGlacken, Gerard P., O'Dwyer, Colm, Schmidt, Michael   +4 more
core   +1 more source

A Negatively Curved Pyrene‐Fused Azaacene

Angewandte Chemie International Edition, EarlyView.
A pyrene‐fused azaacene derivative is reported in which steric overcrowding caused by eight phenyl substituents induces bending of the aromatic framework rather than twisting. ABSTRACT Non‐planar aromatic hydrocarbons display distorted π‐frameworks that give rise to unique optoelectronic properties.
Marco Carini, Miguel Martín‐Arroyo, Manuel Melle‐Franco, Aurelio Mateo‐Alonso   +3 more
wiley   +1 more source

Closed polymer containers based on phenylboronic esters of resorcinarenes

Beilstein Journal of Nanotechnology, 2018
Novel polymer nanospheres (p(SRA-B)) were prepared by cross-linking a sulfonated resorcinarene (SRA) with phenylboronic acid. p(SRA-B) shows good stability in water and can be used as a nanocontainer for the pH- and glucose-controlled substrate release ...
Tatiana Yu. Sergeeva, Rezeda K. Mukhitova, Irek R. Nizameev, Marsil K. Kadirov, Polina D. Klypina, Albina Y. Ziganshina, Alexander I. Konovalov   +6 more
doaj   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Multisite-binding turn-on fluorescent probe for monitoring mitochondrial ATP levels fluctuation in live cells [PDF]

, 2016
10.1002/anie.201510003Angewandte Chemie International Edition5551773 ...
Allue, Ashcroft, Berg, Buckstein, Burnstock, Davalos, Gout, Hardie, Higgins, Imamura, Jiang, Kioka, Knowles, Kobayashi, Kurishita, Kurishita, Lee, Leist, Li, Li, Lichtman, Lin, Lin, Lippert, Liu, Mahato, Mameri, Manfredi, Morii, Moro, Morris, Nishimura, Ojida, Rao, Reungpatthanaphong, Schäferling, Srivastava, Sun, Tarasov, Weitz, Weitz, Xu, Yu, Zamaraeva, Zhang   +44 more
core   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy

Nature Communications
RNA degradation using ribonuclease targeting chimeras (RiboTACs) is a promising approach for cancer therapy. However, potential off-target degradation is a serious issue. Here, a RiboTAC is designed for tumor microenvironment triggered activation.
Yuqi Zhang, Jinfeng Zhu, Ling Qiu, Zhengzhong Lv, Zhongsheng Zhao, Xingxiang Ren, Yirui Guo, Yan Chen, Miao Li, Yurong Fan, Zhixin Han, Yiming Feng, Haibin Shi   +12 more
doaj   +1 more source

Suzuki coupling reactions catalyzed by poly(N-ethyl-4-vinylpyridinium) bromide stabilized palladium nanoparticles in aqueous solution

eXPRESS Polymer Letters, 2008
InIn this work, it was investigated to use of poly(N-ethyl-4-vinylpyridinium) bromide stabilized palladium nanoparticles in the Suzuki reaction between phenylboronic acid and aryl halides in aqueous solution.
doaj   +1 more source