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The Antithyroid Effect of Phenylbutazone
Acta Rheumatologica Scandinavica, 1956SummaryOn 19 patients undergoing Phenylbutazone treatment, 600 mg. by mouth per day for various rheumatic complaints, the antithyroid effect of this drug was studied by the use of repeated tracer iodine tests. The uptake values were reduced after one week's treatment but this effect tended to revert after further treatment.
A.-M. Allgoth +2 more
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Misuse of Veterinary Phenylbutazone
Archives of Internal Medicine, 1995Phenylbutazone is a nonsteroidal anti-inflammatory drug that was commonly prescribed for the treatment of arthritic conditions; it is no longer available for use in humans because of its numerous side effects, including aplastic anemia. We describe a horse trainer who developed gastric ulcers and renal insufficiency as a result of taking veterinary ...
W M McDonnell, S L Carpenter
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AGRANULOCYTOSIS DUE TO PHENYLBUTAZONE
Annals of Internal Medicine, 1957Excerpt It is well known that phenylbutazone is a hazardous medication, although it has been very effective therapeutically in relief of pain of arthritis and similar conditions.
R E Geesaman, F L James
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Management of thrombophlebitis with phenylbutazone
The American Journal of Cardiology, 1959I T IS my purpose to present a treatment for thrombophlebitis which aborts the clinical syndrome, cuts down on the need for nursing care and hospitalization, and has a potential for lessening the long term complications of venous thrombosis. These objectives are attained through the use of phenylhutazone,t a nonhormonal drug with anti-inflammatory ...
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Metabolism of phenylbutazone in rats
Xenobiotica, 1985The metabolism of phenylbutazone has been investigated in female rats dosed with the drug by gavage. The major route of excretion is via the urine; 50% of the dose being excreted in the first 24 h. A small percentage of the dose is excreted in the faeces. Following administration of 14C-phenylbutazone, five labelled, unconjugated hydroxy compounds were
D. M. Alexander +2 more
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The use of phenylbutazone in the horse
Journal of Veterinary Pharmacology and Therapeutics, 2011Soma, L. R., Uboh, C. E., Maylin G. M. The use of phenylbutazone in the horse.J. vet. Pharmacol. Therap. 35, 1–12.This review presents a brief historical prospective of the genesis of regulated medication in the US racing industry of which the nonsteroidal anti‐inflammatory drug (NSAID) phenylbutazone (PBZ) is the focus.
G. M. Maylin +2 more
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Effects of Phenylbutazone in Gout
New England Journal of Medicine, 1954PHENYLBUTAZONE (3, 5-dioxo-l, 2–diphenyl4-n-butyl-pyrazolidin sodium) is a pyrazolon derivative with anti-inflammatory and analgesic properties.1 Its formula is as follows: Success with this drug in the treatment of gout has previously been reported by Gutman and Yu,2 by Kuzell et al.,3 , 4 and by Steinbrocker and his associates.5 In the past year we ...
Peter H. Forsham +5 more
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PHENYLBUTAZONE AND AGRANULOCYTOSIS
JAMA: The Journal of the American Medical Association, 1953To the Editor: —I have just read with interest the report "Agranulocytosis Following Use of Phenylbutazone (Butazolidin ® )" by Hinz and others inThe Journal, Jan. 3, 1953, page 38. During the past year and a half, I have obtained a great deal of experience from using this drug in the treatment of over 700 patients with various arthritides and ...
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Phenylbutazone Ionization Kinetics
Journal of Pharmaceutical Sciences, 1976Phenylbutazone has been associated with bioavailability problems and has shown nonclassical behavior in phase-transport studies. This nonclassical behavior has been attributed, in part, to the fact that phenylbutazone, as a carbon acid, undergoes noninstantaneous ionization kinetics.
J.D. Pipkin, Valentino J. Stella
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