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Ketoprofen Lysine Salt vs. Ketoprofen Acid: Assessing the Evidence for Enhanced Safety and Efficacy. [PDF]

open access: yesLife (Basel)
Graziosi A   +5 more
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PHENYLBUTAZONE AND HEPATITIS

Rheumatology, 1975
During a comparative trial between enteric-coated and rectally administered phenylbutazone in patients with rheumatoid disease, one patient developed a mild hepatitis. She had recently concluded a long period of gold therapy. The natural history of phenylbutazone hepatitis is reviewed on the basis of 41 case histories, and the experience with this ...
Suzanne Alexander   +2 more
openaire   +3 more sources

Phenylbutazone

Pediatrics, 1956
Phenylbutazone (Butazolidin®), introduced into clinical usage in 1952 as an antirheumatic agent in gout, rheumatoid arthritis and other periarticular diseases, has gained widespread usage among adults, and a report of its accidental ingestion by a 2-year-old infant may therefore be of interest.
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The Metabolism of Phenylbutazone in the Rat

Xenobiotica, 1974
Abstract1. After administration of [14C]phenylbutazone by stomach tube to rats 1/3 of the radioactivity was excreted in the faeces and almost 2/3 in the urine over 48 h. Biliary excretion after intraperitoneal injection was slightly more than 1/3 of the dose in 24 h.2.
O. M. Bakke   +2 more
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Phenylbutazone toxicity in ponies

Veterinary Record, 1979
The oral administration of phenylbutazone at a dose rate of approximately 10 mg per kg per day for seven to 14 days resulted in the development of signs of toxicity in seven of eight ponies treated. Clinical signs included anorexia, depression and abdominal oedema.
A.R. Michell, Peter Lees
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Pattern of Phenylbutazone Degradation

Journal of Pharmaceutical Sciences, 1973
Phenylbutazone and phenylbutazone-antacid formulations were examined by TLC for the presence of decomposition products. A procedure was developed for minimizing on-plate oxidation of phenylbutazone during TLC analysis, and preparative TLC was utilized for isolation of the major products of decomposition. Unequivocal identification of the major products
F. Matsui, A. Vincent, D.V.C. Awang
openaire   +3 more sources

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