Results 21 to 30 of about 624 (116)
Muscle &Nerve, Volume 74, Issue 5, Page 1415-1420, November 2026.ABSTRACT Introduction/Aims People living with amyotrophic lateral sclerosis (ALS; pALS) have extensive care needs, from wheelchairs to feeding tubes to caregiving support. The financial impact of these needs on pALS and their caregivers (cALS) has not been fully explored.
Astrid Grouls +5 more
wiley +1 more source
Muscle &Nerve, Volume 74, Issue 5, Page 1398-1405, November 2026.ABSTRACT Introduction/Aims In amyotrophic lateral sclerosis (ALS), SIMOA‐based studies show that baseline serum neurofilament light chain (NfL) predicts the revised ALS Functional Rating Scale (ALSFRS‐R) decline rate and survival. The Roche Elecsys electrochemiluminescence immunoassay (ECLIA) reports values approximately six‐fold lower; cross‐platform ...
Nicholas S. Streicher
wiley +1 more source
Antimicrobial Activity and In Silico ADME Properties of Tyrosol and Their Derivatives Compounds
ChemistrySelect, Volume 11, Issue 41, 3 November 2026.In the present study, tyrosol derivatives were obtained with the aim of improving their antimicrobial activity. Derivative 2 exhibited good antimicrobial activity, with an MIC of 3.9 µg/mL. Derivative 3, meanwhile, showed moderate activity and is novel in the literature. ABSTRACT According to the World Health Organization (WHO), bacterial resistance is
Kathia Raquel Murillo Padilla +6 more
wiley +1 more source
Clinical and genetic characterization of intellectual disability
Developmental Medicine &Child Neurology, Volume 68, Issue 11, Page 1601-1609, November 2026.This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara +14 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni +18 more
wiley +1 more source
Switch from Sodium Phenylbutyrate to Glycerol Phenylbutyrate Improved Metabolic Stability in an Adolescent with Ornithine Transcarbamylase Deficiency [PDF]
, 2016 A male patient, born in 1999, was diagnosed with ornithine transcarbamylase deficiency as neonate and was managed with a strict low-protein diet supplemented with essential amino acids, L-citrulline, and L-arginine as well as sodium benzoate. He had an extensive history of hospitalizations for hyperammonemic crises throughout childhood and early ...
Laemmle Alexander +2 more
openaire +4 more sources
Advanced Science, Volume 13, Issue 56, 9 October 2026.QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li +9 more
wiley +1 more source
ATF3 Promotes Solasonine‐Triggered Ferroptosis in Glioma Cells by Suppressing Glycolysis
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Solasonine inhibits glycolysis by increasing ATF3 expression, thereby increasing hydrogen peroxide levels, promoting ferritinophagy and lipid peroxidation, leading to ferroptosis. Furthermore, hydrogen peroxide activates endoplasmic reticulum stress, promoting ATF3 expression, and the whole process forms a positive feedback loop.
Mingbo Jia +8 more
wiley +1 more source
Hydroxyurea and sodium phenylbutyrate therapy in thalassemia intermedia [PDF]
American Journal of Hematology, 1999 Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia. The reported effects of these agents in increasing total Hb, however, have been inconsistent and there have been no studies on the combination of these medications.
C, Hoppe +4 more
openaire +2 more sources
Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling
Comprehensive Physiology, Volume 16, Issue 5, October 2026.Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond +6 more
wiley +1 more source