Results 131 to 140 of about 24,479 (307)

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment

Smart Molecules, EarlyView.
We developed a red‐light‐activated small‐molecule photosensitizer FNBS, which enables simultaneous photodynamic immunotherapy and RNA interference. FNBS can induce pyroptosis, immunogenic cell death and RNA degradation, avoiding the carrier‐dependent delivery drawbacks of conventional RNAi therapy, converting cold tumors into hot tumors and ...
Xiang Xia, Bingbing Wu, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng   +6 more
wiley   +1 more source

Nationwide distribution, transformation, and risks of p-Phenylenediamines and their quinone transformation products in Chinese agricultural soils

Environment International
p-Phenylenediamines (PPDs) are widely used as antioxidants in tire formulations and are released to the environment via tire wear, where they can be transformed into more toxic p-phenylenediamine-derived quinones (PPD-Qs).
Chao Xu, Lewei He, Wei Wei, Shuren Liu, Xianzhi Huang, Rong Jin, Zili Guo, Shuduan Mao, Dongmei Xu, Xiaohui Sun, Shuang Song, Feng He, Lili Niu, Weiping Liu   +13 more
doaj   +1 more source

P-phenylenediamine

, 2014
P-phenylenediamine (PPD) is een sterk contactallergeen welke gebruikt wordt in oxidatieve haarverven en kan een ernstig contactallergisch eczeem veroorzaken.Hoewel PPD al jaren bekend staat als sterk contactallergeen, is het exacte mechanisme van sensibilisatie en elicitatie nog altijd niet compleet opgehelderd.
openaire   +1 more source

Unveiling the interplay between methylglyoxal and plant growth under abiotic adversity via a red‐emissive probe operated by a ring‐closure mechanism

Smart Molecules, EarlyView.
BH‐PDN is a red‐emissive fluorescent probe that enables methylglyoxal (MGO) detection via a ring‐closure‐triggered turn‐on response. Probe‐based imaging uncovered prominent MGO buildup in Arabidopsis thaliana roots exposed to salinity, extreme temperatures and drought.
Yu‐Long Li, Xin‐Hui‐Zi Li, Ting‐Ting Liu, Yuan Qiu, Xiao‐Gang Luo, Qi Sun, Shu‐Jing Yu   +6 more
wiley   +1 more source

Mechanism of Antiozonant Action. I. Consumption of p-Phenylenediamines in Rubber Vulcanizates during Ozonization

, 1963
The consumption of N,N′-bis(1-methylheptyl)- and N-isopropyl-N′-phenyl-p- phenylenediamine in cis-polybutadiene vulcanizates was measured as a function of the ozonization time and the initial diamine concentration. The results are consistent with a rapid
Carl R. Parks, Otto Lorenz
core   +1 more source

Contact Allergens Relevant to LGBTQI Populations: A Narrative Review and Practical Considerations

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Allergic contact dermatitis (ACD) is a common inflammatory skin disorder with significant morbidity across populations. Sexual and gender minority (SGM) individuals, including LGBTQI populations, are exposed to unique allergens due to gender‐affirming medical therapies, surgical interventions, cosmetics and grooming practices, sexual health ...
Nicholas van Rooij
wiley   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

Immunology, EarlyView.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek   +5 more
wiley   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Study on Diphenylamine Oxidation by Ozone Using Atmospheric Pressure Chemical Ionization Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 40, Issue 20, 30 October 2026.
ABSTRACT Rationale Diphenylamine (DPAH) derivatives, widely used as antioxidants, interact with oxygen molecules (or ozone) to form radicals at the amine group. Although the antioxidation mechanism involves radical processes, separating these radicals using chromatography is challenging. Methods Rapid oxidation of DPAH was achieved through ozonation in
Eunji Chae, Chae Eun Son, Sung‐Seen Choi   +2 more
wiley   +1 more source