Results 91 to 100 of about 66,253 (217)

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

An alternative synthesis of (±)-phenylephrine hydrochloride [PDF]

Maejo International Journal of Science and Technology, 2014
This study presents alternative synthetic pathways and reagents for the preparation of racemic phenylephrine hydrochloride. Using m-hydroxybenzaldehyde as starting material, two separate pathways–epoxidation and bromohydrin formation–are
Aphiwat Teerawutgulrag, Wipanoot Baison, Pakawan Puangsombat, Nuansri Rakariyatham   +3 more
doaj  

Evaluation of Cerebral Blood Flow and Cerebral Autoregulation Using Synthetic Data and In Silico Modeling

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
This study uses simulations and synthetic data to reassess static cerebral autoregulation. Results show cerebral blood flow is strongly influenced by systemic arteriolar resistance and arterial CO2, while mean arterial pressure has a significant but weak effect.
Selim Bozkurt
wiley   +1 more source

Dose-Response Study of Phenylephrine for Preventing Spinal-Induced Hypotension During Cesarean Delivery with Combined Spinal-Epidural Anesthesia Under the Effect of Prophylactic Intravenous Ondansetron

Drug Design, Development and Therapy
Xiao-Xia Sun, Jing Qian, Jia-Ming Fan, Lin Liu, Xia-Fang Jin, Fei Xiao Department of Anesthesia, Jiaxing University Affiliated Women and Children Hospital, Jiaxing City, People’s Republic of ChinaCorrespondence: Xia-Fang Jin; Fei Xiao, Department of ...
Sun XX, Qian J, Fan JM, Liu L, Jin XF, Xiao F   +5 more
doaj  

Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial

Indian Journal of Ophthalmology, 2009
Purpose: To compare the efficacy in pupil dilatation between a mixture containing 0.75% tropicamide and 2.5% phenylephrine and the alternate application of 1% tropicamide and 10% phenylephrine eye drops. Material and Methods
Trinavarat Adisak, Pituksung Auengporn
doaj  

Comparative Efficacy of Intermittent Bolus Doses of Phenylephrine and Norepinephrine in Preventing Maternal Bradycardia during Cesarean Section under Spinal Anesthesia: A Randomized Controlled Trial

Journal of Obstetric Anaesthesia and Critical Care
Background and Aims: Maternal hypotension is a common concern during cesarean sections (CS) with spinal anesthesia and can have adverse consequences for both the mother and fetus.
Devika Sood, Prabhjeet Singh, Gegal Pruthi, Gurpreeti Kaur, Namrata Goyal, Ashima Taneja, Anju Grewal   +6 more
doaj   +1 more source

Murine Biocompatibility Evaluation of an Albumin‐Derived Complex and Nanoparticle Delivery System for Ocular Applications

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Age‐related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late‐stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections.
Amna Abdalbaqi, Nagaraj Kerur, Matthew P. Ohr, Andre F. Palmer, Katelyn E. Swindle‐Reilly   +4 more
wiley   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 3, March 2026.
ABSTRACT Background Preterm infants are at increased risk of perioperative mortality and are among the most vulnerable patients anesthesiologists can encounter. The literature on anesthesia practice in preterm infants is limited, mainly focusing on their physiological immaturity and related pharmacodynamics and pharmacokinetics.
Jaap van der Heijden, Peter Frykholm
wiley   +1 more source

Vasopressor Use in Acute Burn Resuscitation: A Retrospective Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 3, March 2026.
ABSTRACT Background Vasopressors are often introduced in severe burn patients who respond poorly to fluid resuscitation to maintain adequate blood pressure and avoid fluid creep. This study aims to characterise these patients and explore potential correlations between vasopressor use and patient outcomes.
Kristine Knappskog, Kostiantyn Botnar, Julia Kleinhapl, Juquan Song, Amina El Ayadi, Henning Onarheim, Anne Berit Guttormsen, George Golovko, Steven Wolf, Stian Kreken Almeland   +9 more
wiley   +1 more source