Results 241 to 250 of about 62,058 (288)
Some of the next articles are maybe not open access.
The Effect of Phenylephrine on the Cornea
Archives of Ophthalmology, 1979Rabbit corneas were treated with three drops of phenylephrine hydrochloride with the epithelium intact or denuded. Corneal thickness was measured before and after drug treatment, and at various times after treatment the corneas were fixed for scanning and transmission electron microscopic observation.
Harlan J. Pederson +4 more
openaire +3 more sources
Ephedrine is Not Phenylephrine
New England Journal of Medicine, 1998To the Editor: In his review of Dermatology in Emergency Care (Feb. 12 issue),1 Dr. Greaves incorrectly uses the generic name ephedrine for a 2 percent phenylephrine spray used to treat a localized mucosal reaction. Phenylephrine hydrochloride is an α-adrenergic agonist that is useful for topical as well as intravenous vasoconstriction.
openaire +3 more sources
Journal of Pharmaceutical Sciences, 1961
Abstract Lithium aluminum hydride reduction of 3-benzyloxy-N-methylmandelamide followed by debenzylation has afforded phenylephrine.
Scott J. Childress, Peter B. Russell
openaire +3 more sources
Abstract Lithium aluminum hydride reduction of 3-benzyloxy-N-methylmandelamide followed by debenzylation has afforded phenylephrine.
Scott J. Childress, Peter B. Russell
openaire +3 more sources
Pediatric Anesthesia, 2017
SummaryIntroductionIntranasal phenylephrine, an alpha‐1 adrenergic agonist, causes vasoconstriction of the nasal mucosa and is used to reduce bleeding associated with nasotracheal intubation or endoscopic sinus surgery. The purpose of this study was to describe the hemodynamic effects associated with plasma phenylephrine concentrations following ...
Lisa K. Christensen +4 more
openaire +3 more sources
SummaryIntroductionIntranasal phenylephrine, an alpha‐1 adrenergic agonist, causes vasoconstriction of the nasal mucosa and is used to reduce bleeding associated with nasotracheal intubation or endoscopic sinus surgery. The purpose of this study was to describe the hemodynamic effects associated with plasma phenylephrine concentrations following ...
Lisa K. Christensen +4 more
openaire +3 more sources
In Vivo Comparison of Phenylephrine and Phenylephrine Oxazolidine Instilled in the Monkey Eye
Journal of Ocular Pharmacology and Therapeutics, 1987The ocular and cardiovascular effects as well as aqueous humor and plasma concentrations of 10% phenylephrine HCl and 1% phenylephrine oxazolidine (prodrug) were compared in cynomolgus monkeys. A volume of 25 microliters of either drug was administered to one eye followed by blood pressure, pulse, and pupillary measurements at 10 min intervals up to 60
Jeffery G. Piper +3 more
openaire +3 more sources
Ophthalmology, 1991
The authors evaluated the mydriatic effect of phenylephrine oxazolidine prodrug, a lipophilic sympathomimetic that undergoes hydrolysis to phenylephrine as it passes through the cornea and aqueous humor. Double-masked clinical trials were performed randomizing 66 healthy subjects to receive either the silicone vehicle as a placebo, 10% viscous ...
James C. Folk +5 more
openaire +2 more sources
The authors evaluated the mydriatic effect of phenylephrine oxazolidine prodrug, a lipophilic sympathomimetic that undergoes hydrolysis to phenylephrine as it passes through the cornea and aqueous humor. Double-masked clinical trials were performed randomizing 66 healthy subjects to receive either the silicone vehicle as a placebo, 10% viscous ...
James C. Folk +5 more
openaire +2 more sources
Intracorporeal Phenylephrine in the Treatment of Priapism
Journal of Urology, 1996The effectiveness and complications of intracorporeal phenylephrine without aspiration or irrigation as a treatment for priapism were assessed.Nine consecutive patients who presented with priapism were treated with 0.5 mg. phenylephrine diluted in 2 cc normal saline injected directly into the corpus cavernosum.
Denis H. Hosking, N. Muruve
openaire +3 more sources
Pharmaceutical research, 1990
The aqueous humor concentration of phenylephrine and its corresponding mydriatic response were measured over time in New Zealand albino rabbit eyes following a 10-microliters topical instillation of a phenylephrine HCl viscous solution (10%) or a phenylephrine oxazolidine (prodrug) suspension in sesame oil (1 and 10%).
Ronald D. Schoenwald, Du-Shieng Chien
openaire +3 more sources
The aqueous humor concentration of phenylephrine and its corresponding mydriatic response were measured over time in New Zealand albino rabbit eyes following a 10-microliters topical instillation of a phenylephrine HCl viscous solution (10%) or a phenylephrine oxazolidine (prodrug) suspension in sesame oil (1 and 10%).
Ronald D. Schoenwald, Du-Shieng Chien
openaire +3 more sources
The Role of Phenylephrine in Perioperative Medicine
2009Phenylephrine is a synthetic, direct sympathomimetic agent that is mainly used to induce locoregional vasoconstriction. For this purpose, phenylephrine is contained in several decongestant nasal sprays [1] and mydriatics [2] in doses usually not exerting significant systemic cardiovascular effects.
Ertmer, C., Morelli, A., Westphal, M.
openaire +3 more sources
Systemic Effects of Topical Phenylephrine
Archives of Ophthalmology, 1986To the Editor. —We read with great interest the article by Fraunfelder and Meyer in a recent issue of theAmerican Journal of Ophthalmology.1The cases accumulated by the authors, although anecdotal, suggest that deleterious cardiovascular effects may occur secondary to topical application of 2.5% phenylephrine hydrochloride solution.
Melissa M. Brown +2 more
openaire +3 more sources