Results 81 to 90 of about 63,750 (296)

Alpha antiadrenergic effect of Achyrocline bogotensis extract (“Vira Vira”) in isolated rat aortic ring

open access: yesVitae, 2017
Background: The treatment of symptoms of prostatic hyperplasia is among the traditional uses of Achyrocline bogotensis (Kunth) [N.V. “Vira Vira”, Compositae] in Colombia.
Nidya LARA   +2 more
doaj  

Characteristics of drug and dietary supplement inquiries by college athletes. [PDF]

open access: yes, 2010
BackgroundIn the United States, the National Center for Drug Free Sport manages the drug-testing programs for athletes of the National Collegiate Athletic Association (NCAA).
Ambrose, Peter J   +3 more
core   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira   +1 more
wiley   +1 more source

Adipocytes, aldosterone and obesity-related hypertension [PDF]

open access: yes, 2016
Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions.
Friederich-Persson, Malou   +3 more
core   +1 more source

PD‐L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC‐RPE Grafts in Retinal Degeneration

open access: yesCell Proliferation, EarlyView.
We generated immune‐tolerant mature hESC‐RPE cells by overexpressing PD‐L1. PD‐L1‐expressing hESC‐RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC‐RPE‐based therapy for AMD. ABSTRACT Immune rejection
Bowen Li   +11 more
wiley   +1 more source

Generic sample preparation combined with high-resolution liquid chromatography- time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories [PDF]

open access: yes, 2010
A unification of doping-control screening procedures of prohibited small molecule substances—including stimulants, narcotics, steroids, ß2-agonists and diuretics—is highly urgent in order to free resources for new classes such as banned proteins ...
Georgakopoulos, C.G.   +4 more
core   +3 more sources

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

open access: yesCell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang   +4 more
wiley   +1 more source

Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery

open access: yesAdvanced Biomedical Research, 2016
Background: Spinal anesthesia is an accepted technique in hip fracture surgery and prevention of this complication by sympathomimetic agents is of potential clinical significance.
Rahman Abbasivash   +4 more
doaj   +1 more source

Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius. [PDF]

open access: yes, 2018
Stimulation of vagal afferent endings with intravenous phenylbiguanide (PBG) causes both bradycardia and vasodepression, simulating neurally mediated syncope.
Fu, Liang-Wu   +3 more
core   +3 more sources

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