Results 61 to 70 of about 26,955 (257)

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Dietary amino acid intakes associated with a low-phenylalanine diet combined with amino acid medical foods and glycomacropeptide medical foods and neuropsychological outcomes in subjects with phenylketonuria

Data in Brief, 2017
This article provides original data on median dietary intake of 18 amino acids from amino acid medical foods, glycomacropeptide medical foods, and natural foods based on 3-day food records obtained from subjects with phenylketonuria who consumed low ...
Bridget M. Stroup, Sangita G. Murali, Nivedita Nair, Emily A. Sawin, Fran Rohr, Harvey L. Levy, Denise M. Ney   +6 more
doaj  

Unified Neural Lexical Analysis Via Two‐Stage Span Tagging

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Lexical analysis is a fundamental task in natural language processing, which involves several subtasks, such as word segmentation (WS), part‐of‐speech (POS) tagging, and named entity recognition (NER). Recent works have shown that taking advantage of relatedness between these subtasks can be beneficial.
Yantuan Xian, Yefen Zhu, Zhentao Yu, Yuxin Huang, Junjun Guo, Yan Xiang   +5 more
wiley   +1 more source

The Prevalence of Phenylketonuria in Arab Countries, Turkey, and Iran: A Systematic Review

BioMed Research International, 2018
Background/Objectives This paper seeks to identify the prevalence of Phenylketonuria (PKU) in Arab countries, Turkey, and Iran. The study reviewed the existence of comprehensive national newborn screening programs and reported consanguinity rates ...
A. El-Metwally, Lujane Yousef Al-Ahaidib, Alaa Ayman Sunqurah, K. Al-Surimi, M. Househ, A. Alshehri, Omar B. Da’ar, Hira Abdul Razzak, A. Alodaib   +8 more
semanticscholar   +1 more source

An injector testbed based on a direct current gun and an interchangeable very high frequency gun for superconducting continuous‐wave free‐electron lasers

Journal of Synchrotron Radiation, Volume 32, Issue 4, Page 838-848, July 2025.
An injector testbed for continuous‐wave free‐electron lasers based on a direct current gun and an interchangeable very high frequency gun is under construction. Its physical design and performance have been studied carefully.The continuous‐wave free‐electron laser (CW‐FEL), based on superconducting radiofrequency (SRF) technology with an electron bunch
Xinmeng Li, Jitao Sun, Yong Yu, Jiahang Shao, Jiayue Yang, Quan Zhou, Hongli Ding, Lei Shi, Kai Tao, Chenglin Guo, Zhigang He, Zhichao Chen, Zhen Chen, Shaohua Peng, Hongfei Wang, Guoqing Zhang, Baichao Zhang, Zongbin Li, Feng Zhao, Wei Wei, Maomao Huang, Wei Wang, Ming Liu, Chaofeng He, Liangbing Hu, Yaqiong Wang, Han Li, Weiming Yue, Xilong Wang, Guorong Wu, Dongxu Dai, Weiqing Zhang, Xueming Yang   +32 more
wiley   +1 more source

Carbohydrate status in patients with phenylketonuria

Orphanet Journal of Rare Diseases, 2018
BackgroundIn patients with phenylketonuria (PKU), a low-phenylalanine (Phe) diet supplemented with low-protein foods and a Phe-free amino acid mixture favors a dietary intake rich in carbohydrates, but little is known about how these molecules are ...
M. Couce, Paula Sánchez-Pintos, I. Vitoria, M. D. de Castro, L. Aldámiz-Echevarría, Patricia Correcher, A. Fernández‐Marmiesse, Iria Roca, A. Hermida, M. Martínez-Olmos, R. Leis   +10 more
semanticscholar   +1 more source

Systematic Multi‐Trait Study of Genetic Correlation and Causality Relationships Between General Medical Conditions and Mental Disorders

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Increasing evidence has highlighted bidirectional associations between mental disorders and general medical conditions, with underlying causes ranging from lifestyle habits and side effects from medications to genetic contributions. Novel methods now provide a way to estimate the shared genetic underpinnings and the possibility of
Ron Nudel, Maria Da Re, Michael E. Benros   +2 more
wiley   +1 more source

Phenylketonuria: a review [PDF]

Postgraduate Medical Journal, 1970
SummaryThe development of a practical screening procedure for phenylketonuria and the improvement in methods of chemical analysis have led to a realization that Folling’s (1934) disease of phenylketonuria is not a single entity.In this commentary, the current view on some aspects of phenylketonuria will be reviewed and the problems illustrated by ...
openaire   +3 more sources

A historical perspective on Lionel Penrose: Scientist, geneticist and dedicated opponent of eugenics

Annals of Human Genetics, EarlyView.
Abstract The paper explores Lionel Penrose's scientific work. Penrose investigated the causes of mental disorders from clinical and genetic points of view. His investigations on phenylketonuria and Down syndrome helped to demonstrate the heterogenous character of mental disorders, whose causes can range from genetic with high penetrance, to largely ...
Maria Kiladi
wiley   +1 more source

Frequency of the IVS-10nt546 mutation in 44 Turkish phenylketonuria patients

The Turkish Journal of Pediatrics, 1993
The newly identified point mutation in intron 10 of the phenylalanine hydroxylase gene activates a cryptic splice site and results in an in-frame insertion of nine nucleotides between exons 10 and 11 of the processed transcript.
M Ozgüç, I Ozalp, T Coşkun, E Yilmaz, H Erdem, S Ayter   +5 more
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