Results 91 to 100 of about 18,327 (286)

Adaptive strategies of the candidate probiotic E. coli Nissle in the mammalian gut

bioRxiv, 2018
Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function.
Nathan Crook, Aura Ferreiro, Andrew J. Gasparrini, M. Pesesky, Molly K. Gibson, Bin Wang, Xiaoqing Sun, Zevin J Condiotte, S. Dobrowolski, D. Peterson, G. Dantas   +10 more
semanticscholar   +1 more source

Real‐world comparison of first‐line antiseizure monotherapy and the role of age at treatment initiation in newly diagnosed childhood epilepsy: A cohort study from a tertiary center

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the real‐world effectiveness and tolerability of first‐line antiseizure medication (ASM) monotherapy in children with newly diagnosed epilepsy, focusing on comparative outcomes across developmental age groups and ASM types, and identifying clinical risk factors of treatment failure.
Ningshan Li, Huiting Zhang, Chaoran Yang, Xiaoying Qiao, Dezhi Cao, Lina Men, Guangjun Yu, Jianxiang Liao   +7 more
wiley   +1 more source

Estimating Correlations Between Clinical Trial Outcomes Using Generalised Estimating Equations

Oxford Bulletin of Economics and Statistics, EarlyView.
ABSTRACT Accurately estimating the correlations among clinical trial outcomes is crucial for managing the risk of biopharmaceutical investment portfolios. We propose a novel algorithm for estimating correlations in large clinical trial datasets using a generalised estimating equations (GEE) framework.
Yuehao Dai, Andrew W. Lo, Manish Singh, Qingyang Xu, Ruixun Zhang   +4 more
wiley   +1 more source

From Presence to Policy: The Conditional Impact of Women's Representation in Top Management Teams in Chinese Local Governments

Public Administration, EarlyView.
ABSTRACT While public administration research has begun exploring the impact of women's representation in top leadership positions in public organizations, the conditions under which women's representation in top management teams (TMTs) produces policies specifically benefiting women remain underexamined.
Ting Huang, Shahidul Hassan, Anders Ryom Villadsen, Hongtao Yi   +3 more
wiley   +1 more source

The effect of glycomacropeptide-based foods upon blood phenylalanine control in adults and children with phenylketonuria [PDF]

, 2018
Conventional treatment for phenylketonuria restricts dietary phenylalanine to ‘control’ plasma phenylalanine concentrations. Its widespread adoption has largely eradicated the severe neurocognitive defects that previously characterised phenylketonuria ...
Thomson, Roderick
core  

How Different Patterns of Policy Attention Drive Policy Diffusion: Evidence From China's River Chief System

Policy Studies Journal, EarlyView.
ABSTRACT Despite extensive research on policy diffusion, the ways in which policy attention influences this process remain underexplored. This study addressed this gap by distinguishing between three types of policy attention—political speeches, policy issuance and field visits—and investigating their differential impacts when delivered by central and ...
Xiangning Chen, Yahua Wang
wiley   +1 more source

Lanches salgados para adolescentes portadores de fenilcetonúria [PDF]

, 2015
Monografia (graduação)—Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Nutrição, 2015.A dieta extremamente restrita da fenilcetonúria deve ser seguida ao longo de toda a vida.
Prado, Mariana
core  

¿Qué debe saber el pediatra de las hiperfenilalaninemias? [PDF]

, 2015
ResumenLas hiperfenilalaninemias se definen por un nivel sanguíneo de fenilalanina sobre 2mg/dl. La principal causa es una mutación en el gen que codifica la fenilalanina hidroxilasa que cataliza la reacción que transforma la fenilalanina en tirosina ...
Arias, Carolina, Bravo, Paulina, Cabello, Juan Francisco, Campo, Karen, Castro, Gabriela, Cornejo, Verónica, Hamilton, Valerie, Peredo, Pilar, Raimann, Erna   +8 more
core   +1 more source

Phenylketonuria screening in Iranian newborns: a systematic review and meta-analysis [PDF]

, 2020
Mehdi Shokri, Parviz Karimi, Hadis Zamanifar, Fatemeh Kazemi, Gholamreza Badfar, Milad Azami   +5 more
openalex   +1 more source

Untargeted Metabolomics for Diagnosis, Monitoring, and Understanding the Pathophysiology of Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Inherited metabolic disorders (IMDs) encompass a diverse and expanding group of rare diseases caused by genetic disruptions mainly in metabolic enzymes and transporters. Clinical diagnosis of IMDs presents significant challenges due to phenotypic heterogeneity, nonspecific symptoms, and the limited scope of current targeted biochemical assays ...
Jonathan Martens, Udo F. H. Engelke, Ron A. Wevers, Dirk J. Lefeber, Purva Kulkarni   +4 more
wiley   +1 more source