A small-molecule degron with a phenylpropionic acid scaffold
Targeted protein degradation (TPD), employing proteolysis-targeting chimeras (PROTACs) composed of ligands for both a target protein and ubiquitin ligase (E3) to redirect the ubiquitin-proteasome system (UPS) to the target protein, has emerged as a promising strategy in drug discovery.
Shusuke Tomoshige +9 more
openaire +2 more sources
OBJECTIVE - We investigated whether the dual PPARα/γ agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity.
Zadelaar, A.S.M. +8 more
core
Moderator Effects on Recoil Tritium Reactions with Lithium β-Phenylpropionate
The recoil tritium reactions were studied with lithium beta-phenylpropionate having both the aromatic and aliphatic C-H bonds in the molecule, mainly in terms of the moderator effect on the intramolecular tritium distribution. Recoil tritium atoms were produced by the 6Li(n,alpha)3H reaction. Water molecules were used as the moderator.
OOHASHI, Kunio, MORIKAWA, Naotake
openaire +3 more sources
Comparative clinical evaluation of endothelin receptor antagonists in pulmonary arterial hypertension using a multi-criteria decision analysis framework. [PDF]
Cao Z +7 more
europepmc +1 more source
Synthesis of Non-Steroidal Anti-Inflammatory Drugs Pelubiprofen, Loxoprofen, and Carprofen Through Batch and Continuous-Flow Photo-Favorskii Rearrangement. [PDF]
Ferrario S +4 more
europepmc +1 more source
Perioperative loxoprofen sodium is associated with lower pain and anxiety levels in dental implant surgery: a cohort study in China. [PDF]
Lou A, Pei H, Liu D, He R, Li M.
europepmc +1 more source
Hydrocinnamic Acid From Candida albicans: Isolation, Characterization, and Antibacterial Activity Against Multidrug-Resistant Bacteria. [PDF]
Kaviraj M, Jayappriyan KR, Raja R.
europepmc +1 more source
Effectiveness of Saroglitazar in MASLD Patients: A Prospective, Real-World Assessment of Liver and Metabolic Health. [PDF]
Gupta M +4 more
europepmc +1 more source

