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Conformational preferences in model antiviral compounds: A spectroscopic and computational study of phenylurea and 1,3-diphenylurea

Physical Chemistry Chemical Physics, 2004
The conformational preferences of two model anti-viral pharmaceuticals, phenylurea and 1,3-diphenylurea, isolated in the gas phase, have been explored using a combination of ultra-violet and infra-red ion-dip spectroscopy and quantum chemical computation. Two conformers have been assigned for each species associated with cis and trans configurations of
R. Emery   +3 more
semanticscholar   +2 more sources

Characterization of organophosphorus compounds and phenylurea herbicides by positive and negative ion thermospray liquid chromatography—mass spectrometry

Journal of Chromatography A, 1989
Abstract Positive-on (PI) mode and negative-ion (NI) mode thermospray liquid chromatography—mass spectrometry (LC—MS) were used to characterize three different groups of environmentally significant compounds: organophosphorus pesticides, phenylurea herbicides and trialkyl phosphates.
D. Barceló, J. Albaigés
semanticscholar   +2 more sources

Aroma profiling of Shine Muscat grape provides detailed insights into the regulatory effect of gibberellic acid and N-(2-chloro-4-pyridinyl)-N-phenylurea applications on aroma quality.

Food Research International, 2023
As plant growth regulators, gibberellic acid (GA3) and CPPU [forchlorfenuron, N-(2-chloro-4-pyridinyl)-N-phenylurea] are widely used in the production of table grapes. However, how these compounds regulate the aroma quality remains unclear.
Yu-Sen Wu   +5 more
semanticscholar   +1 more source

A core-shell structured magnetic covalent organic framework as a magnetic solid-phase extraction adsorbent for phenylurea herbicides.

Journal of Chromatography A, 2021
In this work, a core-shell structured magnetic covalent organic framework named as M-TpDAB was constructed with 3,3'-diaminobenzidine (DAB) and 1,3,5-triformylphloroglucinol (Tp) as building units.
Li-Ying Guo   +7 more
semanticscholar   +1 more source

Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea

Archiv der Pharmazie, 2020
A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glycosidase (α‐Gly).
Hayreddin Gezegen   +8 more
semanticscholar   +1 more source

Computational study of novel inhibitory molecule, 1-(4-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-phenylurea, with high potential to competitively block ATP binding to the RNA dependent RNA polymerase of SARS-CoV-2 virus

Journal of Biomolecular Structure and Dynamics, 2021
For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery.
P. Sharma   +12 more
semanticscholar   +1 more source

Synthesis, Physicochemical, Computational and Biological Evaluation of Phenylurea Derivatives as CNS agents.

Central Nervous System Agents in Medicinal Chemistry, 2021
BACKGROUND A series of phenylurea derivatives were designed and synthesized, The target compounds were subjected to pharmacological studies. Various other parameters such as physicochemical properties, computational studies, and % similarity were also ...
Sandeep Singh, Shwetank Verma
semanticscholar   +1 more source

Abiotic and Biotic Processes Governing the Fate of Phenylurea Herbicides in Soils: A Review

open access: yesCritical Reviews in Environmental Science and Technology, 2015
EA ECOLDUR CT3International audiencePhenylurea herbicides are world widely used for controlling the development of various broad leaf weeds in cereal crops.
Muhammad Arshad   +2 more
exaly   +2 more sources

Comparative analysis of sugar, acid, and volatile compounds in CPPU-treated and honeybee-pollinated melon fruits during different developmental stages.

Food Chemistry, 2022
Plant growth regulator N-(2-chloro-4-pyridyl)-N'-phenylurea (CPPU) is widely used in fruit production. However, the mechanism in which CPPU affects melon fruit quality, especially aroma compound, remains unclear.
Haiwen Chen   +4 more
semanticscholar   +1 more source

Construction of magnetic recoverable porous electron-rich organic frameworks for efficiently enrichment of phenylurea herbicides from water and milk samples prior to HPLC detection.

Food Chemistry
Porous electron-rich organic frameworks have attracted an increased attention in the adsorption and removal of pollutants due to their abundant electron-rich nitrogen atoms, which can effectively interact with positively charged substance. In this study,
Hua Wang   +5 more
semanticscholar   +1 more source

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