Results 101 to 110 of about 51,442 (242)
The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma [PDF]
, 2007 Janos Geli, Nimrod Kiss, Fredrik Lanner, Theodoros Foukakis, Natalia Natalishvili, Olle Larsson, Per Kogner, Anders Höög, Geoffrey Clark, Tomas J. Ekström, Martin Bäckdahl, Filip Farnebo, Catharina Larsson +12 moreopenalex +1 more sourceTumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer
Advanced Science, Volume 12, Issue 46, December 11, 2025.An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng +30 morewiley +1 more sourceGenetic analysis of pheochromocytoma and paraganglioma complicating cyanotic congenital heart disease
, 2022 Tatsuki Ogasawara, Yoichi Fujii, Nobuyuki Kakiuchi, Yusuke Shiozawa, R. Sakamoto, Yoshihiro Ogawa, Katsuki Ootani, Etsuro Ito, Tomoaki Tanaka, Kenichiro Watanabe, Yusaku Yoshida, Noriko Kimura, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa +16 moreopenalex +2 more sourcesPreoperative Amlodipine Is More Efficacious Than Prazosin in Preventing Intraoperative Haemodynamic Instability in Pheochromocytoma/Paraganglioma Patients: Interim Analysis of a Pilot Randomized Controlled Study [PDF]
, 2021 Saba Samad Memon, Sanjeet Kumar Jaiswal, Robin Garg, Rohit Barnabas, Manjunath Goroshi, Anurag Lila, Vijaya Sarathi, Abhay Dalvi, Mahadeo Garale, Indrani Hemantkumar, Rajendra Patel, Shrikanta Oak, Virendra Patil, Nalini S. Shah, Tushar Bandgar +14 moreopenalex +1 more sourceClinically Inspired Multimodal Treatment Using Induced Neural Stem Cells‐Derived Exosomes Promotes Recovery of Traumatic Brain Injury through Microglial Modulation
Advanced Science, Volume 12, Issue 46, December 11, 2025.This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract
Traumatic brain injury (TBI) poses serious Jiaojiao Li, Maoxiang Xu, Boyu Cai, Xiangyu Li, Zhanping Liang, Xiaohuan Xia, Haitao Zhang, Zhiwen Zhang, Fei Tan, Jialin Charlie Zheng +9 morewiley +1 more sourcePharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants
British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3366-3377, December 2025.Aims
Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.Mohammad Ghasemi, Ji Yun Kim, Lisa Seitz, Lixia Jin, Paul G. Foster, Kai H. Liao, Tzuling Cheng, Elaine Paterson, Maria Velinova, Nicole Rivera Rosario, Reza Khosravan, Balaji Agoram +11 morewiley +1 more source