Results 101 to 110 of about 74,986 (277)

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Systemic Steroid Application Caused Sudden Death of a Patient with Sudden Deafness

Case Reports in Otolaryngology, 2013
A 63-year-old man, who was diagnosed with sudden sensorineural hearing loss (SSHL), showed severe hypertension 10 hours after prednisolone administration. Subsequently, the patient suddenly died due to pulmonary edema.
Eriko Ogino-Nishimura, Takayuki Nakagawa, Ichiro Tateya, Harukazu Hiraumi, Juichi Ito   +4 more
doaj   +1 more source

Characterisation of ERK distribution and activity in rat pheochromocytoma cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University [PDF]

, 1998
Nerve growth factor (NGF) binds to the NGF receptor, TrkA, at the tips of nerve cell axons, sending a signal that prevents programmed cell death and causes survival, growth, and differentiation of the nerve cell.
MacCormick, Matthew Edgar
core  

Endocrine cells share expression of N-CAM with neurones [PDF]

, 1987
The reeent explosive interest in eell adhesion molecules (CAMs) is a direet eonsequence of the fundamental roles they are thought to play during early embryogenesis and tissue formation [1,2].
Couly, Covault, Crossin, Daniloff, Edelman, Edelman, Friedlander, Gennarini, Goridis, Hirn, Hoffman, Jorgensen, Jorgensen, Langley, Langley, Langley, Langley, Noble, Obrink, Rougon, Rutishauser, Sternberger, Stoeckel, Thiery, Thiery, Van   +25 more
core   +1 more source

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara, Eda Dogan, Vildan Bozok, Cagdas Aktan, Ece Cakiroglu, Zuhal Eroglu, Duygu Aygunes Jafari, Kemal Sami Korkmaz, Serif Senturk, Buket Kosova   +9 more
wiley   +1 more source

Composite pheochromocytoma with a malignant peripheral nerve sheath tumor: Case report and review of the literature

Asian Journal of Surgery, 2016
Adrenal tumors with more than one cellular component are uncommon. Furthermore, an adrenal tumor composed of a pheochromocytoma and a malignant peripheral nerve sheath tumor is extremely rare.
Takeshi Namekawa, Takanobu Utsumi, Takashi Imamoto, Koji Kawamura, Takashi Oide, Tomoaki Tanaka, Naoki Nihei, Hiroyoshi Suzuki, Yukio Nakatani, Tomohiko Ichikawa   +9 more
doaj   +1 more source

Hyperhidrosis: don't sweat it

Internal Medicine Journal, EarlyView.
Abstract Hyperhidrosis is an under‐reported and under‐treated condition that causes significant patient morbidity. Secondary causes require consideration, but the vast majority of cases are idiopathic. The condition is encountered by a range of clinicians, including neurologists, dermatologists and endocrinologists, and it pays to be familiar with the ...
Mitchell J. Lycett, Karl Ng
wiley   +1 more source

Weakly Supervised Detection of Pheochromocytomas and Paragangliomas in CT [PDF]

arXiv
Pheochromocytomas and Paragangliomas (PPGLs) are rare adrenal and extra-adrenal tumors which have the potential to metastasize. For the management of patients with PPGLs, CT is the preferred modality of choice for precise localization and estimation of their progression.
arxiv  

STUDIES ON THE BIOGENESIS AND METABOLISM OF NOREPINEPHRINE IN PATIENTS WITH PHEOCHROMOCYTOMA* [PDF]

, 1959
Albert Sjoerdsma, Lemuel C. Leeper, Luther L. Terry, Sidney Udenfriend   +3 more
openalex   +1 more source

Pancreatic neuroendocrine tumors in children and adolescents—Data from the German MET studies (1997–2023)

Journal of Neuroendocrinology, EarlyView.
Abstract Pancreatic neuroendocrine tumors (panNETs) are rare pediatric malignancies with age‐specific clinical and biological features. Data on their presentation, management, and outcomes remain limited. This retrospective study analyzed 28 pediatric panNET cases from the German Malignant Endocrine Tumor (MET) Registry enrolled between 1997 and 2024 ...
Katharina Karges, Marina Kunstreich, Ulrich‐Frank Pape, Jörg Fuchs, Christian Vokuhl, Michael Abele, Dominik T. Schneider, Ines B. Brecht, Constantin Lapa, Michael C. Frühwald, Peter Vorwerk, Antje Redlich, Michaela Kuhlen   +12 more
wiley   +1 more source