Results 41 to 50 of about 48,572 (243)

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

A Rare Cause of Pheochromocytoma; Neurofibromatosis Type 1-Noonan Syndrome

, 2014
Neurofibromatosis (NF) Type 1 (NF-1) is an autosomal dominant disease with a prevalence of about 1/3000. NF-1 is a neurocutaneous syndrome characterized by cafe au lait macules, neurofibroma, optic glioma, lisch nodules, and symptoms involving other ...
Ersen Karakılıç, Mehtap Navdar Başaran, Mazhar Müslüm Tuna, Berçem Ayçiçek Doğan, Büşranur Çavdarlı, Yasemin Tütüncü, Serdar Güler, Dilek Berker   +7 more
core   +1 more source

Laparoscopic partial adrenalectomy for bilateral pheochromocytomas in a boy with von Hippel-Lindau disease [PDF]

, 2000
Objectives: In adults, increasing numbers of adrenalectomies for pheochromocytomas are performed laparoscopically. We report for the first time laparoscopic bilateral subtotal adrenalectomy for pheochromocytomas in an 8-year-old boy with von Hippel ...
Elsner, Romy, Neumann, Hartmut, Janetschek, Günter, Neumann, Hartmut P. H., Radmayr, Christian, Bartsch, Georg   +5 more
core   +1 more source

Probiotic Spore Inspired Oral Drug Delivery System With Multiple‐Barriers‐Crossing Ability Modulates Gut‐Brain Axis for Parkinson's Disease Therapy

Exploration, EarlyView.
Inspired by the germination of probiotic spores, we utilize the excellent characteristics of spores to break through multiple barriers of oral brain‐targeted delivery. Besides the probiotics mediated gut‐brain communication, the spore coat proteins derived nanosystems with multiple‐barriers‐crossing ability alleviate neurodegeneration.
Qianhua Feng, Yuying Mei, Jia Zhang, Liying Sun, Bingqian Si, Huimin Zhou, Huifang Xiao, Runhan Liu, Jieyun Zhang, Lei Wang   +9 more
wiley   +1 more source

Ischaemic stroke as the initial presentation of a pheochromocytoma associated with neurofibromatosis type 1

Asian Journal of Internal Medicine
Pheochromocytoma is a rare but well-recognised manifestation of neurofibromatosis type 1 (NF1). Ischaemic stroke has been rarely reported in patients with pheochromocytoma. It can be due to either hypertension or vasospasm. A 33-year-old woman presented
S. W. Gnanathayalan, B. M. S. Fernando, U. Bulugahapitiya   +2 more
doaj   +1 more source

Pheochromocytoma: A single-center 20-year experience

Urological Science, 2019
Objective: Pheochromocytomas are catecholamine-producing neuroendocrine tumors arising from chromaffin cells of the adrenal medulla or extra-adrenal paraganglia. There is no large-scale study in Taiwan at present.
Lung-Feng Cheng, Shih-Che Tseng, Chia-Cheng Yu, Jen-Tai Lin, Jeng-Yu Tsai, I-Hsuan Chen, Yin-Shen Chen   +6 more
doaj   +1 more source

Pheochromocytoma crisis [PDF]

, 2014
KEY CLINICAL MESSAGE: Adrenergic crisis induced by a pheochromocytoma leads to life-threatening catecholamine-induced hemodynamic disturbances. Successful treatment of a pheochromocytoma crisis demands prompt diagnosis, vigorous pharmacological therapy ...
Clavien, Pierre-Alain, Tschuor, Christoph, Sadri, Helen   +2 more
core   +1 more source

Swallowing‐Related Quality of Life After Carotid Body Tumor Resection: A Longitudinal Trajectory Analysis

Head &Neck, EarlyView.
ABSTRACT Objectives To identify longitudinal swallowing‐related QoL trajectories after carotid body tumor (CBT) resection and explore associated characteristics. Methods A prospective study assessed swallowing‐related QoL using the MD Anderson Dysphagia Inventory at nine timepoints from preoperation to 12 months postdischarge.
Pan Chen, Qiao‐Dan Lu, He‐Jing Liang, Ming‐Hua Guo, Jia‐Pin Chen, Chun‐Xu Yang, Guang‐Chao Gu, Lei Wang, Yue‐Hong Zheng   +8 more
wiley   +1 more source

Metoclopramide‐Induced Pheochromocytoma Crisis: A Case Report and Literature Review

Clinical Case Reports
Pheochromocytoma is a catecholamine‐secreting neuroendocrine tumor originating in the adrenal medulla. In patients with pheochromocytoma, paroxysmal over‐secretion of catecholamines can be triggered by various medications, including the commonly used ...
Yuki Yamanishi, Kazuki Iio, Keiki Shimizu, Wataru Kasahara, Jun Hamaguchi   +4 more
doaj   +1 more source

Is It a Pheochromocytoma? [PDF]

The Journal of Clinical Hypertension, 2007
The patient is a 44‐year‐old man with a 4‐year history of intermittently elevated blood pressure (BP) controlled by diet and exercise. Three months before evaluation he described daily “spikes” of BP with sharp unilateral headaches. He was seen in the emergency department with a BP of 212/106 mm Hg and was started on hydrochlorothiazide 25 mg daily ...
openaire   +2 more sources