Results 71 to 80 of about 108,225 (340)

Targeted Radionuclide Therapy for Patients with Metastatic Pheochromocytoma and Paraganglioma: From Low-Specific-Activity to High-Specific-Activity Iodine-131 Metaiodobenzylguanidine

Cancers, 2019
Low-specific-activity iodine-131–radiolabeled metaiodobenzylguanidine (I-131-MIBG) was introduced last century as a potential systemic therapy for patients with malignant pheochromocytomas and paragangliomas.
C. Jimenez, W. Erwin, B. Chasen
semanticscholar   +1 more source

Laparoscopic partial adrenalectomy for bilateral pheochromocytomas in a boy with von Hippel-Lindau disease [PDF]

, 2000
Objectives: In adults, increasing numbers of adrenalectomies for pheochromocytomas are performed laparoscopically. We report for the first time laparoscopic bilateral subtotal adrenalectomy for pheochromocytomas in an 8-year-old boy with von Hippel ...
Bartsch, Georg, Elsner, Romy, Janetschek, Günter, Neumann, Hartmut, Radmayr, Christian   +4 more
core   +1 more source

Pharmacokinetics, pharmacodynamics and safety of casdatifan, a novel hypoxia‐inducible factor‐2α inhibitor, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Casdatifan is an orally bioavailable small‐molecule hypoxia‐inducible factor‐2α (HIF‐2α) inhibitor currently in development for treating patients with clear cell renal cell carcinomas. The aim of this study was to characterize the pharmacokinetics (PK), pharmacodynamics and safety of casdatifan in healthy participants.
Mohammad Ghasemi, Ji Yun Kim, Lisa Seitz, Lixia Jin, Paul G. Foster, Kai H. Liao, Tzuling Cheng, Elaine Paterson, Maria Velinova, Nicole Rivera Rosario, Reza Khosravan, Balaji Agoram   +11 more
wiley   +1 more source

Review of Pediatric Pheochromocytoma and Paraganglioma

Frontiers in Pediatrics, 2017
Pheochromocytoma (PCC) and paraganglioma (PGL) are rare chromaffin cell tumors which secrete catecholamines and form part of the family of neuroendocrine tumors.
R. Bholah, T. Bunchman
semanticscholar   +1 more source

Routine genetic screening with a multi-gene panel in patients with pheochromocytomas [PDF]

, 2017
PURPOSE: Several new gene mutations have been reported in recent years to be associated with a risk of familial pheochromocytoma. However, it is unclear as to whether extensive genetic testing is required in all patients. METHODS: The clinical data
Cranston, Treena, Grossman, Ashley B., Isidori, Andrea, Jafar mohammadi, Bahram, Mihai, Radu, Pal, Aparna, Sadler, Greg, Sbardella, Emilia, Shine, Brian   +8 more
core   +1 more source

Predictive Factors of Malignancy in Cervical Paragangliomas: A Retrospective Study

Head &Neck, EarlyView.
ABSTRACT Background Early predictive factors of metastatic cervical paragangliomas (cPG) are lacking. Methods This multicenter retrospective study included patients with at least one cPG. Metastatic cPG were defined by the histological presence of lymph node metastases or distant metastases.
Garance Haw, Maxime Fieux, Anthime Flaus, Hélène Lasolle, Juliette Abeillon, Myriam Decaussin‐Petrucci, Dylan Pavie, Benjamin Verillaud, Philippe Herman, Patrick Feugier, Fatima Ameur, Pierre Philouze, Françoise Borson‐Chazot, Philippe Ceruse   +13 more
wiley   +1 more source

CT Characteristics of Pheochromocytoma: Relevance for the Evaluation of Adrenal Incidentaloma

Journal of Clinical Endocrinology and Metabolism, 2018
Background Up to 7% of all adrenal incidentalomas (AIs) are pheochromocytomas (PCCs). In the evaluation of AI, it is generally recommended that PCC be excluded by measurement of plasma-free or 24-hour urinary fractionated metanephrines.
L. Canu, J. A. V. Van Hemert, M. Kerstens, R. Hartman, A. Khanna, I. Kraljević, D. Kaštelan, C. Badiu, U. Ambroziak, A. Tabarin, M. Haissaguerre, E. Buitenwerf, A. Visser, M. Mannelli, W. Arlt, V. Chortis, I. Bourdeau, Nadia Gagnon, M. Buchy, F. Borson‐Chazot, T. Deutschbein, M. Fassnacht, A. Hubalewska-Dydejczyk, Marcin Motyka, Ewelina Rzepka, R. Casey, B. Challis, M. Quinkler, L. Vroonen, A. Spyroglou, F. Beuschlein, C. Lamas, W. Young, I. Bancos, H. Timmers   +34 more
semanticscholar   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Detection of severe hypertension in a patient with neurofibromatosis type 1 during anesthesia induction: a case report

Journal of Medical Case Reports, 2019
Background Neurofibromatosis type 1 has a higher prevalence of pheochromocytoma and paraganglioma than the general population: 1.0–5.7% versus 0.2–0.6%.
Juan Wang, Guohua Wei, Zhongyun Wang, He Huang   +3 more
doaj   +1 more source

Antitumor effects of radionuclide treatment using α-emitting meta-211At-astato-benzylguanidine in a PC12 pheochromocytoma model

European Journal of Nuclear Medicine and Molecular Imaging, 2018
PurposeTherapeutic options for patients with malignant pheochromocytoma are currently limited, and therefore new treatment approaches are being sought. Targeted radionuclide therapy provides tumor-specific systemic treatments.
Yasuhiro Ohshima, Hitomi Sudo, Shigeki Watanabe, K. Nagatsu, Atsushi B. Tsuji, T. Sakashita, Y. Ito, K. Yoshinaga, T. Higashi, N. Ishioka   +9 more
semanticscholar   +1 more source