Results 71 to 80 of about 47,675 (242)
Bilateral primary adrenal lymphoma
Journal of General and Family Medicine, EarlyView.
Rio Shimizu, Shogo Shirota
wiley +1 more source
PI5P4K inhibitors: promising opportunities and challenges
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi+16 more
wiley +1 more source
Systemic Steroid Application Caused Sudden Death of a Patient with Sudden Deafness
A 63-year-old man, who was diagnosed with sudden sensorineural hearing loss (SSHL), showed severe hypertension 10 hours after prednisolone administration. Subsequently, the patient suddenly died due to pulmonary edema.
Eriko Ogino-Nishimura+4 more
doaj +1 more source
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman+13 more
wiley +1 more source
PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer
ABSTRACT Alterations in the homologous recombination repair genes, such as BRCA1 and BRCA2, are prevalent in various cancers, presenting a unique opportunity to develop synthetic lethal strategies that target homologous recombination deficiency (HRD).
Yohei Okuda+8 more
wiley +1 more source
Adrenal tumors with more than one cellular component are uncommon. Furthermore, an adrenal tumor composed of a pheochromocytoma and a malignant peripheral nerve sheath tumor is extremely rare.
Takeshi Namekawa+9 more
doaj +1 more source
STUDIES ON THE BIOGENESIS AND METABOLISM OF NOREPINEPHRINE IN PATIENTS WITH PHEOCHROMOCYTOMA* [PDF]
Albert Sjoerdsma+3 more
openalex +1 more source