The Lysis cassette of jumbophage PhiKZ [PDF]
Scientific ReportsPseudomonas jumbophage phiKZ is prominent because of the proteinaceous nuclear structure that is formed during the infection cycle, protecting the replicating phage DNA from host nucleases.
Prasanth Manohar +4 more
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Phage phiKZ—The First of Giants [PDF]
Viruses, 2021 The paper covers the history of the discovery and description of phiKZ, the first known giant bacteriophage active on Pseudomonas aeruginosa. It also describes its unique features, especially the characteristic manner of DNA packing in the head around a ...
Victor Krylov +8 more
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Isolation and characterization of fMGyn-Pae01, a phiKZ-like jumbo phage infecting Pseudomonas aeruginosa [PDF]
Virology JournalBackground Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections, and belongs to the group of ESKAPE pathogens that are the leading cause of healthcare-associated infections and have high level of antibiotic ...
Kira Ranta +2 more
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Structure of the bacteriophage PhiKZ non-virion RNA polymerase bound to a p119L open promoter analogue [PDF]
IUCrJBacteriophage ΦKZ (PhiKZ) was the first identified member of a family of massive bacterial viruses. ΦKZ infects Pseudomonas aeruginosa, which kills tens of thousands every year, and it therefore has potential as a bacteriophage therapy. On infection, ΦKZ
Chao-Sheng Chen +3 more
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Aztreonam Lysine Increases the Activity of Phages E79 and phiKZ against Pseudomonas aeruginosa PA01 [PDF]
Microorganisms, 2021 Pseudomonas aeruginosa is a pernicious bacterial pathogen that is difficult to treat because of high levels of antibiotic resistance. A promising alternative treatment option for such bacteria is the application of bacteriophages; the correct combination
Carly M. Davis +2 more
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Maturation of Pseudo-Nucleus Compartment in P. aeruginosa, Infected with Giant phiKZ Phage [PDF]
Viruses, 2020 The giant phiKZ phage infection induces the appearance of a pseudo-nucleus inside the bacterial cytoplasm. Here, we used RT-PCR, fluorescent in situ hybridization (FISH), electron tomography, and analytical electron microscopy to study the morphology of ...
Yana A. Danilova +5 more
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Correction for Antonova et al., “Genomic transfer via membrane vesicle: a strategy of giant phage phiKZ for early infection” [PDF]
Journal of VirologyDaria Antonova +13 more
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Genomic transfer via membrane vesicle: a strategy of giant phage phiKZ for early infection. [PDF]
J VirolDuring infection, the giant phiKZ phage forms a specialized structure at the center of the host cell called the phage nucleus. This structure is crucial for safeguarding viral DNA against bacterial nucleases and for segregating the transcriptional ...
Antonova D +13 more
europepmc +5 more sources
The Dynamics of Synthesis and Localization of Jumbo Phage RNA Polymerases inside Infected Cells [PDF]
Viruses, 2023 A nucleus-like structure composed of phage-encoded proteins and containing replicating viral DNA is formed in Pseudomonas aeruginosa cells infected by jumbo bacteriophage phiKZ. The PhiKZ genes are transcribed independently from host RNA polymerase (RNAP)
Daria Antonova +11 more
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Combination of genetically diverse Pseudomonas phages enhances the cocktail efficiency against bacteria [PDF]
Scientific Reports, 2023 Phage treatment has been used as an alternative to antibiotics since the early 1900s. However, bacteria may acquire phage resistance quickly, limiting the use of phage treatment.
Ampapan Naknaen +5 more
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