Results 101 to 110 of about 434 (125)

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Wright RC, Lovell SC, Richmond A, Harrison C, Ashworth E, Kadioglu A, Fothergill JL, Friman V, Westra ER, Brockhurst MA.   +9 more
europepmc   +1 more source

Structure of the bacteriophage PhiKZ non-virion RNA polymerase [PDF]

Nucleic Acids Research, 2021
Abstract Bacteriophage ΦKZ is the founding member of a family of massive bacterial viruses. It is considered to have therapeutic potential as its host, Pseudomonas aeruginosa , is an opportunistic, intrinsically antibiotic resistant, pathogen that kills tens of thousands worldwide ...
Natalia De Martín Garrido, Kailash Ramlaul, T O Artamonova   +2 more
exaly   +9 more sources

Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

Virology, 2014
A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P.
Olga S Sokolova, N A Kiselev, O V Shaburova   +2 more
exaly   +4 more sources

Investigation of PhiKZ phage therapy against Pseudomonas aeruginosa in mouse pneumonia model

Turkish Journal of Medical Sciences, 2018
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined.
Kubra Can, Uğur Aksu
exaly   +7 more sources

Crystal structure and location of gp131 in the bacteriophage phiKZ virion [PDF]

Virology, 2012
Pseudomonas phage ϕKZ and its two close relatives ϕPA3 and 201ϕ2-1 are very large bacteriophages that form a separate branch in phage classification because their genomes are very different from the rest of GenBank sequence data. The contractile tail of ϕKZ is built from at least 32 different proteins, but a definitive structural function is assigned ...
Mikhail M Shneider, Nina N Sykilinda, Konstantin A Miroshnikov   +2 more
exaly   +5 more sources

Genomic characterization of bacteriophage pEt-SU, a novel phiKZ-related virus infecting Edwardsiella tarda

Archives of Virology, 2019
A bacteriophage infecting Edwardsiella tarda (named pEt-SU) was isolated from freshwater collected in Chung-ju, South Korea. The whole genome of pEt-SU was 276,734 bp in length, representing the first giant phage infecting Edwardsiella reported to date. A total of 284 putative open reading frames were predicted and annotated.
Sang Guen Kim, Sib Sankar Giri, Saekil Yun   +2 more
exaly   +4 more sources

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Interspecies migration and evolution of bacteriophages of the genus phiKZ: The purpose and criteria of the search for new phiKZ-like bacteriophages

Russian Journal of Genetics, 2010
Some properties of bacteriophages with large (200 kb and more) sequenced genomes have been compared. In contrast to other large bacteriophages from different families, bacteriophages active on pseudomonads of various species (phiKZ-like bacterio phages) have some common features, which suggests their phylogenetic relationship and independence of their ...
Konstantin A Miroshnikov, S V Krylov, E A Pleteneva   +2 more
exaly   +2 more sources

Properties of the endolytic transglycosylase encoded by gene 144 of Pseudomonas aeruginosa bacteriophage phiKZ

Biochemistry (Moscow), 2006
Bacteriophage endolysins degrading bacterial cell walls are prospective enzymes for therapy of bacterial infections. The genome of the giant bacteriophage phiKZ of Pseudomonas aeruginosa encodes two endolysins, gene products (g.p.) 144 and 181, which are homologous to lytic transglycosylases.
Konstantin A Miroshnikov, N N Sykilinda, V V Mesyanzhinov   +2 more
exaly   +3 more sources

Assembly of phiKZ bacteriophage Inner Body during infection

Biochemical and Biophysical Research Communications
The giant myovirus phiKZ is characterised by an Inner Body (IB) structure within its capsid, crucial for orderly DNA packaging. The IB is composed of six phiKZ-specific proteins. Notably, four of these IB proteins are co-injected with DNA into the host cell, where they potentially play a role in attacking the bacterial cell.
Anna Nichiporenko, Daria Antonova, M A Khodorkovskii   +2 more
exaly   +3 more sources

Atomic force microscopy analysis of bacteriophages PhiKZ and T4

Journal of Electron Microscopy, 2001
Bacteriophage phiKZ was investigated by atomic force microscopy (AFM) and transmission electron microscopy (TEM). The well-known phage T4 was used as a reference sample. Reproducible contact mode AFM images of native and partially disintegrated particles of bacteriophage phiKZ in air were obtained.
N, Matsko, D, Klinov, A, Manykin, V, Demin, S, Klimenko   +4 more
openaire   +2 more sources