Results 111 to 120 of about 434 (125)

Characterisation of broad-spectrum phiKZ like jumbo phage and its utilisation in controlling multidrug-resistant Pseudomonas aeruginosa isolates

Microbial Pathogenesis, 2022
The emergence of highly virulent multidrug-resistant P. aeruginosa has become increasingly evident among hospital-acquired infections and has raised the need for alternative therapies. Phage therapy can be one such alternative to antibiotic therapy to combat multidrug-resistant pathogenic bacteria, but this requires the availability of phages with a ...
Praveen Rai, Ballamoole Krishna Kumar, Vijaya Kumar Deekshit   +2 more
exaly   +3 more sources

Factors Influencing the Synonymous Codon and Amino Acid Usage Bias in AT-rich Pseudomonas aeruginosa Phage PhiKZ

Acta Biochimica Et Biophysica Sinica, 2005
To reveal how the AT-rich genome of bacteriophage PhiKZ has been shaped in order to carry out its growth in the GC-rich host Pseudomonas aeruginosa, synonymous codon and amino acid usage bias of PhiKZ was investigated and the data were compared with that of P. aeruginosa.
T C Ghosh
exaly   +2 more sources

The genome of bacteriophage φKZ of Pseudomonas aeruginosa

Journal of Molecular Biology, 2002
Bacteriophage phiKZ is a giant virus that efficiently infects Pseudomonas aeruginosa strains pathogenic to human and, therefore, it is attractive for phage therapy. We present here the complete phiKZ genome sequence and a preliminary analysis of its genome structure. The 280,334 bp genome is a linear, circularly permutated and terminally redundant, A+T-
Vadim V, Mesyanzhinov, Johan, Robben, Barbara, Grymonprez, Victor A, Kostyuchenko, Maria V, Bourkaltseva, Nina N, Sykilinda, Victor N, Krylov, Guido, Volckaert   +7 more
openaire   +2 more sources

The structural peptidoglycan hydrolase gp181 of bacteriophage φKZ

Biochemical and Biophysical Research Communications, 2008
Gp181 (2237 amino acids) of Pseudomonas aeruginosa bacteriophage phiKZ (Myoviridae) is a structural virion protein, which bears a peptidoglycan hydrolase domain near its C-terminus. This protein is supposed to degrade the peptidoglycan locally during the infection process.
Yves, Briers, Konstantin, Miroshnikov, Oleg, Chertkov, Alexei, Nekrasov, Vadim, Mesyanzhinov, Guido, Volckaert, Rob, Lavigne   +6 more
openaire   +2 more sources

[Interspecific migration and evolution of bacteriophages of the genus phiKZ: the purpose and criteria of the search for new phiKZ-like bacteriophages].

Genetika, 2010
Some properties of bacteriophages with large (200 kb and more) sequenced genomes have been compared. In contrast to other large bacteriophages from different families, bacteriophages active on pseudomonads of various species (phiKZ-like bacteriophages) have some common features, which suggests their phylogenetic relationship and independence of their ...
V N, Krylov, K A, Miroshnikov, S V, Krylov, V P, Veĭko, E A, Pletneva, O V, Shaburova, M V, Burkal'tseva   +6 more
openaire   +1 more source

[Certain physico-chemical properties of bacteriophage phiKZ].

Molekuliarnaia biologiia, 1980
Using UV-spectroscopy and circular dichroism (CD) phi KZ bacteriophage and its DNA were investigated. From the value of optical densities in the 320--400 nm range the size of the phi KZ bacteriophage's head was determined; the diameter of phi KZ bacteriophage head was found to be equal to 1300 +/- 100 A. phi KZ bacteriophage DNA has block structure and
B V, Tiaglov, V N, Krylov, T G, Plotnikova, V E, Minaev, V I, Permogorov   +4 more
openaire   +1 more source

Pseudolysogeny of Pseudomonas aeruginosa bacteria infected with φKZ-like bacteriophages

Russian Journal of Genetics, 2010
In this work, a final piece of evidence proving that bacteria Pseudomonas aeruginosa are capable of transition to the pseudolysogenic state after infection with phiKZ-like phages has been produced. It was shown that the decisive factor in this process is multiple infection of bacteria with bacteriophages belonging to this genus.
E A, Pletnev, S V, Krylov, O V, Shaburova, M V, Burkal'tseva, K A, Miroshnikov, V N, Krylov   +5 more
openaire   +2 more sources

“φKZ-like viruses”, a proposed new genus of myovirus bacteriophages

Archives of Virology, 2007
The proposed phiKZ genus of myoviruses has 21 members. Phages are virulent, lyse Pseudomonas bacteria, and are characterized by very large heads and correspondingly high DNA contents. The genome of the type virus, phiKZ, has 306 ORFs and over 280 kbp and is the second-largest phage genome known.
V N, Krylov, D M, Dela Cruz, K, Hertveldt, H-W, Ackermann   +3 more
openaire   +2 more sources

[Pseudomonas bacteriophage phiKZ--possible model for studying the genetic control of morphogenesis].

Genetika, 1978
A description of structure and some bilogical properties of a new virulent Pseudomonas phage, phiKZ, is given in the paper. Phage phiKZ has unique characteristics of particle (a large size of the head and the presence in the head of a structure which is visible on electron micrographs as crosswise striated substance).
V N, Krylov, I Zh, Zhazykov
openaire   +1 more source

A Three-dimensional Cryo-electron Microscopy Structure of the Bacteriophage ϕKZ Head

Journal of Molecular Biology, 2005
The three-dimensional structure of the Pseudomonas aeruginosa bacteriophage phiKZ head has been determined by cryo-electron microscopy and image reconstruction to 18A resolution. The head has icosahedral symmetry measuring 1455 A in diameter along 5-fold axes and a unique portal vertex to which is attached an approximately 1800 A-long contractile tail.
Andrei, Fokine, Victor A, Kostyuchenko, Andrey V, Efimov, Lidia P, Kurochkina, Nina N, Sykilinda, Johan, Robben, Guido, Volckaert, Andreas, Hoenger, Paul R, Chipman, Anthony J, Battisti, Michael G, Rossmann, Vadim V, Mesyanzhinov   +11 more
openaire   +2 more sources