Results 11 to 20 of about 741 (150)

Structure of the bacteriophage PhiKZ non-virion RNA polymerase [PDF]

Nucleic Acids Research, 2021
Bacteriophage ΦKZ is the founding member of a family of massive bacterial viruses. It is considered to have therapeutic potential as its host, Pseudomonas aeruginosa, is an opportunistic, intrinsically antibiotic resistant, pathogen that kills tens of ...
Natàlia deYMartín Garrido, Mariia Orekhova, Yuen Ting Emilie Lai Wan Loong, Anna Litvinova, K. Ramlaul, T. Artamonova, A. Melnikov, P. Serdobintsev, Christopher H. S. Aylett, M. Yakunina   +9 more
semanticscholar   +9 more sources

Characterization of two related Erwinia myoviruses that are distant relatives of the PhiKZ-like Jumbo phages. [PDF]

PLoS ONE, 2018
Bacteriophages are a major force in the evolution of bacteria due to their sheer abundance as well as their ability to infect and kill their hosts and to transfer genetic material.
Daniel K Arens, T Scott Brady, John L Carter, Jenny A Pape, David M Robinson, Kerri A Russell, Lyndsay A Staley, Jason M Stettler, Olivia B Tateoka, Michelle H Townsend, Kiara V Whitley, Trevor M Wienclaw, Taryn L Williamson, Steven M Johnson, Julianne H Grose   +14 more
doaj   +5 more sources

Nucleus-forming jumbophage PhiKZ therapeutically outcompetes non-nucleus-forming jumbophage Callisto. [PDF]

iScience
With the recent resurgence of phage therapy in modern medicine, jumbophages are currently under the spotlight due to their numerous advantages as anti-infective agents. However, most significant discoveries to date have primarily focused on nucleus-forming jumbophages, not their non-nucleus-forming counterparts. In this study, we compare the biological
Naknaen A, Samernate T, Saeju P, Nonejuie P, Chaikeeratisak V.   +4 more
europepmc   +5 more sources

Differential Effect of Newly Isolated Phages Belonging to PB1-Like, phiKZ-Like and LUZ24-Like Viruses against Multi-Drug Resistant Pseudomonas aeruginosa under Varying Growth Conditions [PDF]

Viruses, 2017
In this study, we characterize three phages (SL1 SL2, and SL4), isolated from hospital sewage with lytic activity against clinical isolates of multi-drug resistant Pseudomonas aeruginosa (MDR-PA).
Simone Latz, Alex Krüttgen, Helga Häfner, Eva Miriam Buhl, Klaus Ritter, Hans-Peter Horz   +5 more
doaj   +5 more sources

Correction to 'Structure of the bacteriophage PhiKZ non-virion RNA polymerase'. [PDF]

Nucleic Acids Res, 2021
de Martín Garrido N, Orekhova M, Lai Wan Loong YTE, Litvinova A, Ramlaul K, Artamonova T, Melnikov AS, Serdobintsev P, Aylett CHS, Yakunina M.   +9 more
europepmc   +4 more sources

Structure of the Bacteriophage PhiKZ Non-virion RNA Polymerase Transcribing from its Promoter p119L. [PDF]

J Mol Biol
Bacteriophage ΦKZ (PhiKZ) is the founding member of a family of giant bacterial viruses. It has potential as a therapeutic as its host, Pseudomonas aeruginosa, kills tens of thousands of people worldwide each year. ΦKZ infection is independent of the host transcriptional apparatus; the virus forms a "nucleus", producing a proteinaceous barrier around ...
de Martín Garrido N, Chen CS, Ramlaul K, Aylett CHS, Yakunina M.   +4 more
europepmc   +4 more sources

Integrative omics analysis of Pseudomonas aeruginosa virus PA5oct highlights the molecular complexity of jumbo phages [PDF]

Environmental Microbiology, Volume 22, Issue 6, Page 2165-2181, June 2020., 2020
Summary Pseudomonas virus vB_PaeM_PA5oct is proposed as a model jumbo bacteriophage to investigate phage‐bacteria interactions and is a candidate for phage therapy applications. Combining hybrid sequencing, RNA‐Seq and mass spectrometry allowed us to accurately annotate its 286,783 bp genome with 461 coding regions including four non‐coding RNAs ...
Cédric Lood, Katarzyna Danis‐Wlodarczyk, Bob G. Blasdel, Ho Bin Jang, Dieter Vandenheuvel, Yves Briers, Jean‐Paul Noben, Vera van Noort, Zuzanna Drulis‐Kawa, Rob Lavigne   +9 more
wiley   +3 more sources

A ribosome-interacting jumbophage protein associates with the phage nucleus to facilitate efficient propagation. [PDF]

PLoS Pathogens
Bacteriophages must hijack the gene expression machinery of their bacterial host to efficiently replicate. Recently, we have shown that the early-expressed protein gp014 of Pseudomonas nucleus-forming phage phiKZ forms a stable complex with the host ...
Wichanan Wannasrichan, Sucheewin Krobthong, Chase J Morgan, Emily G Armbruster, Milan Gerovac, Yodying Yingchutrakul, Patompon Wongtrakoongate, Jörg Vogel, Chanat Aonbangkhen, Poochit Nonejuie, Joe Pogliano, Vorrapon Chaikeeratisak   +11 more
doaj   +2 more sources

Characterization and Genomic Analysis of a Novel Jumbo Bacteriophage vB_StaM_SA1 Infecting Staphylococcus aureus With Two Lysins [PDF]

Frontiers in Microbiology, 2022
The development of new antimicrobial agents is critically needed due to the alarming increase in antibiotic resistance in bacterial pathogens. Phages have been widely considered as effective alternatives to antibiotics.
Bingyan Zhang, Bingyan Zhang, Huzhi Sun, Feiyang Zhao, Qian Wang, Qiang Pan, Yigang Tong, Huiying Ren   +7 more
doaj   +2 more sources

Novel Giant Phages vB_AerVM_332-Vera and vB_AerVM_332-Igor and Siphophage vB_AerVS_332-Yulya Infecting the Same Aeromonas veronii Strain [PDF]

Viruses
Three novel Aeromonas phages vB_AerVS_332-Yuliya, vB_AerVM_332-Vera, and vB_AerVM_332-Igor and their host Aeromonas veronii CEMTC7594 were found in the same water + sediments sample collected in a freshwater pond.
Igor V. Babkin, Vera V. Morozova, Yuliya N. Kozlova, Valeria A. Fedorets, Artem Y. Tikunov, Tatyana A. Ushakova, Alevtina V. Bardasheva, Elena V. Zhirakovskaya, Nina V. Tikunova   +8 more
doaj   +2 more sources