Results 31 to 40 of about 347 (94)

Structure of the Bacteriophage PhiKZ Non-virion RNA Polymerase Transcribing from its Promoter p119L. [PDF]

J Mol Biol
Bacteriophage ΦKZ (PhiKZ) is the founding member of a family of giant bacterial viruses. It has potential as a therapeutic as its host, Pseudomonas aeruginosa, kills tens of thousands of people worldwide each year. ΦKZ infection is independent of the host transcriptional apparatus; the virus forms a "nucleus", producing a proteinaceous barrier around ...
de Martín Garrido N, Chen CS, Ramlaul K, Aylett CHS, Yakunina M.   +4 more
europepmc   +3 more sources

Transcription Profiling of Bacillus subtilis Cells Infected with AR9, a Giant Phage Encoding Two Multisubunit RNA Polymerases

mBio, 2017
Bacteriophage AR9 is a recently sequenced jumbo phage that encodes two multisubunit RNA polymerases. Here we investigated the AR9 transcription strategy and the effect of AR9 infection on the transcription of its host, Bacillus subtilis.
Daria Lavysh, Maria Sokolova, Marina Slashcheva, Konrad U. Förstner, Konstantin Severinov   +4 more
doaj   +1 more source

Investigation of PhiKZ phage therapy against Pseudomonas aeruginosa in mouse pneumonia model

TURKISH JOURNAL OF MEDICAL SCIENCES, 2018
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined.
Can, Kubra, Aksu, Ugur, Yenen, Osman Sadi   +2 more
openaire   +3 more sources

Classification of Myoviridae bacteriophages using protein sequence similarity

BMC Microbiology, 2009
Background We advocate unifying classical and genomic classification of bacteriophages by integration of proteomic data and physicochemical parameters. Our previous application of this approach to the entirely sequenced members of the Podoviridae fully ...
Ackermann Hans W, Nilsson Anders S, Mahadevan Padmanabhan, Seto Donald, Summer Elizabeth J, Darius Paul, Lavigne Rob, Kropinski Andrew M   +7 more
doaj   +1 more source

Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

Virology, 2014
A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P.
Sokolova, O.S., Shaburova, O.V., Pechnikova, E.V., Shaytan, A.K., Krylov, S.V., Kiselev, N.A., Krylov, V.N.   +6 more
openaire   +2 more sources

Cryo-EM Study of the Pseudomonas Bacteriophage φKZ [PDF]

Structure, 2007
The phiKZ virus is one of the largest known bacteriophages. It infects Pseudomonas aeruginosa, which is frequently pathogenic in humans, and, therefore, has potential for phage therapy. The phiKZ virion consists of an approximately 1450 A diameter icosahedral head and an approximately 2000 A long contractile tail.
Fokine, Andrei, Battisti, Anthony J., Bowman, Valorie D., Efimov, Andrei V., Kurochkina, Lidia P., Chipman, Paul R., Mesyanzhinov, Vadim V., Rossmann, Michael G.   +7 more
openaire   +2 more sources

[Stucture of PhiKZ bacteriophage particles].

Voprosy virusologii, 1979
The structure of the particle of a new bacteriophage Pseudomonas phiKZ was studied. The particle of phiKZ bacteriophage was shown to have some features distinguishing this phage from all those known heretofore: a large size of the head and DNA and the presence in the head of a special structural formation named the central body.
V N, Krylov, T A, Smirnova, B A, Rebentish, I B, Minenkova   +3 more
openaire   +1 more source

NOVEL APPROACH TO COMPOSITION OF BACTERIOPHAGE MIXTURES FOR ANTIBACTERIAL THERAPY

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Evaluate antibacterial activity of an experimental mixture of phages, belonging to several well-studied species. Materials and methods. The study was carried out using a group of 55 clinical Pseudomonas aeruginosa strains of various origins, 4 mono ...
E. A. Pleteneva, O. V. Shaburova, M. V. Burkaltseva, S. V. Krylov, A. M. Kaplan, E. N. Chesnokova, O. A. Polygach, N. N. Voroshilova, N. A. Mikhailova, V. V. Zverev, V. N. Krylov   +10 more
doaj  

Characterization of tail sheath protein of giant bacteriophage φKZ Pseudomonas aeruginosa

Virology, 2009
The tail sheath protein of giant bacteriophage phiKZ Pseudomonas aeruginosa encoded by gene 29 was identified and its expression system was developed. Localization of the protein on the virion was confirmed by immunoelectron microscopy. Properties of gene product (gp) 29 were studied by electron microscopy, immunoblotting and limited trypsinolysis ...
Kurochkina, LP, Aksyuk, AA, Sachkova, MY, Sykilinda, NN, Mesyanzhinov, VV   +4 more
openaire   +3 more sources

PhiKZ baseplate structure

PhiKZ is a bacteriophage that infects Pseudomonas aeruginosa, an opportunistic human pathogen. The phage phiKZ is known for its large genome and complex structure, making it a notable subject for structural biology studies. Among all its parts, the baseplate is the most complex. It adheres to the phage prey and triggers the genome ejection.
Seoane Blanco Mateo, Homola Miroslav, Füzik Tibor, Plevka Pavel   +3 more
openaire   +2 more sources