Results 131 to 140 of about 886,649 (291)

Minimal Residual Disease Detection: Implications for Clinical Diagnosis and Cancer Patient Treatment

MedComm, Volume 6, Issue 6, June 2025.
Currently, a variety of methods such as flow cytometry, polymerase chain reaction, next‐generation sequencing, and other emerging methods are used for the detection of minimal residual disease, each of which has its own unique strengths and limitations and, more importantly, promising clinical applications.
Meiling Song, Wenjing Pan, Xinjie Yu, Jie Ren, Congli Tang, Zhu Chen, Zhe Wang, Yan Deng, Nongyue He, Hongna Liu, Song Li   +10 more
wiley   +1 more source

Population Pharmacokinetics‐Pharmacodynamics and Exposure‐Response of Ropeginterferon Alfa‐2b in Chinese and Japanese Patients With Polycythemia Vera

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Ropeginterferon alfa‐2b (ropeg) represents a new‐generation interferon‐based therapy approved for polycythaemia vera (PV) treatment. This study aimed to elucidate its population pharmacokinetics‐pharmacodynamics (PopPK‐PD) and exposure‐response (E‐R) relationships.
Albert Qin, Kazuya Shimoda, Shanshan Suo, Rongfeng Fu, Keita Kirito, Daoxiang Wu, Jason Liao, Haoqi Chen, Lei Wu, Xia Su, Yucheng Gao, Toshiaki Sato, Yaning Li, Jingjing Zhang, Weihong Shen, Wei Wang, Lei Zhang, Jie Jin, Norio Komatsu   +18 more
wiley   +1 more source

BLINATUMOMAB IN THE THERAPY OF ACUTE B-LYMPHOID LEUKEMIA

Mediterranean Journal of Hematology and Infectious Diseases
Blinatumomab, a CD19-CD3 bispecific T cell engager (BiTE), has two recombinant single-chain variable fragments that temporarily link CD3+ T cells and CD19+ B cells, leading to the T cell-mediated lysis of neoplastic B cells.
Ugo Testa, Elvira Pelosi, Germana Castelli, Patrizia Chiusolo   +3 more
doaj   +1 more source

Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia [PDF]

, 1979
LB Vogler, WM Crist, PC Vinson, A Sarrif, MG Brattain, MS Coleman   +5 more
openalex   +1 more source

Ecological Realism Accelerates Epigenetic Aging in Mice

Aging Cell, Volume 24, Issue 6, June 2025.
Living environment shapes mammalian aging, but laboratory conditions lack the ecological realism of natural social, physical, and microbial environments. Comparing traditionally laboratory‐reared and “re‐wilded” C57BL/6J mice, we reveal accelerated, genomic region‐dependent epigenetic aging in the liver under naturalistic field conditions, highlighting
Matthew N. Zipple, Ivan Zhao, Daniel Chang Kuo, Sol Moe Lee, Michael J. Sheehan, Wanding Zhou   +5 more
wiley   +1 more source

Therapeutic Strategies for Relapsed or Refractory B‐Cell Acute Lymphoblastic Leukemia in Adult Patients: Optimizing the Use of Monoclonal Antibodies

European Journal of Haematology, Volume 114, Issue 6, Page 938-952, June 2025.
ABSTRACT The treatment landscape for relapsed or refractory acute lymphoblastic leukemia (RR ALL) has evolved significantly with the introduction of monoclonal antibodies such as blinatumomab and inotuzumab ozogamicin. These agents have demonstrated remarkable efficacy, achieving high response rates and minimal residual disease (MRD) negativity ...
Antonella Bruzzese, Enrica Antonia Martino, Caterina Labanca, Giulio Caridà, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Noemi Puccio, Antonino Neri, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source

A HIDDEN PHILADELPHIA CHROMOSOME [PDF]

British Journal of Haematology, 1983
J. A. Liu Yin, H. Walker, T. O. Kumaran
openaire   +2 more sources

Chronic myeloid leukemia (CML): prognostic factors and survival analysis

São Paulo Medical Journal
The prognostic value of different factors upon diagnosis of CML was analysed in 45 Philadelphia (Ph1)-positive patients. The median survival was 48 months.
Gisele Wally Braga, Maria de Lourdes Lopes Ferrari Chauffaille, José Eduardo Cajado Moncau, Elizabeth Xisto Souto, Maria Regina Regis Silva, José Kerbauy   +5 more
doaj   +1 more source

Sex chromosome evolution: The classical paradigm and so much beyond [PDF]

arXiv
Sex chromosomes have independently evolved in species with separate sexes in most lineages across the tree of life. However, the well-accepted canonical model of sex chromosome evolution is not universally supported. There is no single trajectory for sex chromosome formation and evolution across the tree of life, suggesting the underlying mechanisms ...
arxiv  

Excluded volume effect enhances the homology pairing of model chromosomes [PDF]

arXiv, 2015
To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a ...
arxiv