Results 41 to 50 of about 886,649 (291)

Evaluation of Common Genetic Disorders in Myeloproliferative Neoplasms [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2011
Introduction: The myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by excessive production of blood cells by  hematopoietic precursors. Typically, they include polycythemia vera (PV), essential thrombocythemia (ET),
Mehrdad Payandeh, Farhad Shaveisi Zadeh, Mohammad Erfan Zare, Kamran Mansouri, Reza Khodarahmi, Saeed Alimoradi, Hoshang Yousefi, Fatemeh Darabi   +7 more
doaj   +1 more source

Bilateral Serous Retinal Detachment in Lymphoid Blast Crisis of Chronic Myeloid Leukemia

Case Reports in Ophthalmology, 2021
We herein report a patient with Philadelphia chromosome-positive lymphoid blast crisis of chronic myeloid leukemia (CML), who presented with bilateral serous retinal detachment (SRD).
Kyohei Umemura, Kyoko Fujita, Akiko Jinno, Ayano Nakamura, Motohiro Kamei   +4 more
doaj   +1 more source

Studying the age of onset and detection of Chronic Myeloid Leukemia using a three-stage stochastic model [PDF]

arXiv, 2022
Chronic Myeloid Leukemia (CML) is a biphasic malignant clonal disorder that progresses, first with a chronic phase, where the cells have enhanced proliferation only, and then to a blast phase, where the cells have the ability of self-renewal. It is well-recognized that the Philadelphia chromosome (which contains the BCR-ABL fusion gene) is the ...
arxiv  

p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia

Haematologica, 2012
Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome. The p185BCR/ABL or the p210BCR/ABL fusion proteins are encoded as a result
Afsar A. Mian, Anna Metodieva, Yousef Najajreh, Oliver G. Ottmann, Jamal Mahajna, Martin Ruthardt   +5 more
doaj   +1 more source

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias.

New England Journal of Medicine, 2006
BACKGROUND The BCR-ABL tyrosine kinase inhibitor imatinib is effective in Philadelphia chromosome-positive (Ph-positive) leukemias, but relapse occurs, mainly as a result of the outgrowth of leukemic subclones with imatinib-resistant BCR-ABL mutations ...
M. Talpaz, N. Shah, H. Kantarjian, N. Donato, J. Nicoll, R. Paquette, J. Cortes, S. O'brien, C. Nicaise, E. Bleickardt, M. Blackwood-Chirchir, V. Iyer, Tai-Tsang Chen, F. Huang, A. DeCillis, C. Sawyers, C. Sawyers   +16 more
semanticscholar   +1 more source

ChrSNet: Chromosome Straightening using Self-attention Guided Networks [PDF]

arXiv, 2022
Karyotyping is an important procedure to assess the possible existence of chromosomal abnormalities. However, because of the non-rigid nature, chromosomes are usually heavily curved in microscopic images and such deformed shapes hinder the chromosome analysis for cytogeneticists.
arxiv  

"Transformation of chronic myelogenous leukemia to Multiple Myeloma: A case report " [PDF]

Acta Medica Iranica, 2003
Chronic myelogenous leukemia (CML) is a stem cell disorder sometimes associated with lymphoproliferative disorders. CML may precede a lymphoproliferative disorder.
"Ghavamzadeh A, Alimoghaddam K, Mehdipour P, Sharifian R, Schwanitz G, Shamshiri AR "   +5 more
doaj   +1 more source

Efficacy and safety of low‐dose imatinib in an elderly patient with mixed phenotype acute leukemia with t(9;22)(q34;q11.2);BCR‐ABL1

Clinical Case Reports, 2021
Low‐dose imatinib with monitoring of drug concentrations in blood may successfully control Philadelphia chromosome‐positive mixed phenotype acute leukemia (Ph+MPAL), particularly in elderly patients with comorbidities.
Yusuke Okayama, Teruhito Takakuwa, Ippei Otomaru, Mirei Horiuchi, Akiko Miura, Taku Araki, Yotaro Fujitani, Ryosuke Yamamura   +7 more
doaj   +1 more source

A unique three-way Philadelphia chromosome variant t(4;9;22)(q21;q34;q11.2) in a newly diagnosed patient with chronic phase chronic myeloid leukemia: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Chronic myeloid leukemia is a hematologic malignancy associated with the fusion of two genes: BCR and ABL1. This fusion results from a translocation between chromosomes 9 and 22, which is called the Philadelphia chromosome.
Yuka Torii, Kana Nanjo, Tomomi Toubai, Masashi Hosokawa, Ryo Sato, Akane Yamada, Keiko Aizawa, Masahito Himuro, Satoshi Ito, Masakazu Yamamoto, John Magenau, Ryan Wilcox, Kenichi Ishizawa   +12 more
doaj   +1 more source

Genetic Landscape of Myeloproliferative Neoplasms with an Emphasis on Molecular Diagnostic Laboratory Testing

Life, 2021
Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic myeloid leukemia (CML), or somatic mutations in JAK2, CALR, or MPL resulting in ...
Arti Easwar, Alexa J. Siddon
doaj   +1 more source