Results 71 to 80 of about 42,888 (218)
The Philadelphia Chromosome in an Unusual Case of Myeloproliferative Disease [PDF]
, 1965 Clark W. Heath, William C. Moloney
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Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis
Biomarker Research, 2018 Background A feature of myeloproliferative neoplasia is transforming to more aggressive and malignant myeloid neoplasia, including acute myeloid leukemia.
Marte Karen Brattås +8 more
doaj +1 more source
A computational dynamic model of combination treatment for type II inhibitors with asciminib
Protein Science, Volume 34, Issue 8, August 2025.Abstract Despite continuous strides forward in drug development, resistance to treatment looms large in the battle against cancer as well as communicable diseases. Chronic myeloid leukemia (CML) is treated with targeted therapy and treatment is personalized when resistance arises.
J. Roadnight Sheehan +2 more
wiley +1 more source
Chronic Granulocytic Leukaemia: Demonstration of the Philadelphia Chromosome in Cultures of Spleen Cells [PDF]
, 1965 A. S. D. Spiers, A.G. Baikie
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Haematologica, 2014 There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.
José Luis Piñana +15 more
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Genetic Architecture of Immune Cell DNA Methylation in the Rhesus Macaque
Molecular Ecology, Volume 34, Issue 15, August 2025.ABSTRACT Genetic variation that impacts gene regulation, rather than protein function, can have strong effects on trait variation both within and between species. Epigenetic mechanisms, such as DNA methylation, are often an important intermediate link between genotype and phenotype, yet genetic effects on DNA methylation remain understudied in natural ...
Christina E. Costa +12 more
wiley +1 more source
Journal of Hematology & OncologyBackground Several studies have suggested that chemotherapy-free regimens consisting of blinatumomab and a BCR::ABL1 tyrosine kinase inhibitor are highly effective in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL).
Nicholas J. Short +12 more
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Cancer treatment and survivorship statistics, 2025
CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 308-340, July/August 2025.Abstract The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the American Cancer Society and the National ...
Nikita Sandeep Wagle +9 more
wiley +1 more source
Discovery of the Philadelphia chromosome: a personal perspective [PDF]
Journal of Clinical Investigation, 2007 Almost 50 years ago, David Hungerford and I noticed an abnormally small chromosome in cells from patients with chronic myelogenous leukemia (CML). This article is a personal perspective of the events leading to the discovery of this chromosome, which became known as the Philadelphia chromosome.
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Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia [PDF]
, 1979 LB Vogler +5 more
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