Results 71 to 80 of about 886,649 (291)

Accurate chromosome segregation by probabilistic self-organization [PDF]

BMC Biology 2015 13:65, 2014
Background: For faithful chromosome segregation during cell division, correct attachments must be established between sister chromosomes and microtubules from opposite spindle poles through kinetochores (chromosome bi-orientation). Incorrect attachments of kinetochore microtubules (kMTs) lead to chromosome mis-segregation and aneuploidy, which is often
arxiv   +1 more source

A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias.

New England Journal of Medicine, 2013
BACKGROUND Ponatinib is a potent oral tyrosine kinase inhibitor of unmutated and mutated BCR-ABL, including BCR-ABL with the tyrosine kinase inhibitor-refractory threonine-to-isoleucine mutation at position 315 (T315I).
J. Cortes, Dong-Kee Kim, J. Pinilla-Ibarz, P. L. Coutre, R. Paquette, C. Chuah, F. Nicolini, J. Apperley, H. Khoury, M. Talpaz, J. Dipersio, D. DeAngelo, E. Abruzzese, D. Réa, M. Baccarani, M. Müller, C. Gambacorti-Passerini, S. Wong, S. Lustgarten, V. Rivera, T. Clackson, C. Turner, F. Haluska, F. Guilhot, M. Deininger, A. Hochhaus, T. Hughes, J. Goldman, N. Shah, H. Kantarjian   +29 more
semanticscholar   +1 more source

Identification of the Philadelphia (Ph-1) Chromosome [PDF]

Blood, 1970
Abstract The presence of a marker G, which later converted into the Ph-1 chromosome, in a female patient with chronic myelogenous leukemia, permitted identification of the G chromosome from which the Ph-1 originated as a member of the early replicating, G-22 pair.
Jose Egozcue, Felix Marco, Felix Prieto, Geronimo Forteza   +3 more
openaire   +3 more sources

Using Orientation to Distinguish Overlapping Chromosomes [PDF]

arXiv, 2022
A difficult step in the process of karyotyping is segmenting chromosomes that touch or overlap. In an attempt to automate the process, previous studies turned to Deep Learning methods, with some formulating the task as a semantic segmentation problem. These models treat separate chromosome instances as semantic classes, which we show to be problematic,
arxiv  

Blinatumomab compared with standard of care for the treatment of adult patients with relapsed/refractory Philadelphia chromosome–positive B‐precursor acute lymphoblastic leukemia

Cancer, 2019
A single‐arm, phase 2 trial demonstrated the efficacy and safety of blinatumomab, a bispecific T‐cell–engaging antibody construct, in patients with relapsed/refractory (r/r) Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL), a ...
A. Rambaldi, J. Ribera, H. Kantarjian, H. Dombret, O. Ottmann, A. Stein, C. Tuglus, Xiaoyue Zhao, Christopher Kim, G. Martinelli   +9 more
semanticscholar   +1 more source

AutoKary2022: A Large-Scale Densely Annotated Dataset for Chromosome Instance Segmentation [PDF]

arXiv, 2023
Automated chromosome instance segmentation from metaphase cell microscopic images is critical for the diagnosis of chromosomal disorders (i.e., karyotype analysis). However, it is still a challenging task due to lacking of densely annotated datasets and the complicated morphologies of chromosomes, e.g., dense distribution, arbitrary orientations, and ...
arxiv  

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia

Haematologica, 2018
Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both as first-line therapy and after imatinib intolerance or ...
T. Hughes, P. Laneuville, P. Rousselot, D. Snyder, D. Réa, N. Shah, D. Paár, E. Abruzzese, A. Hochhaus, J. Lipton, J. Cortes   +10 more
semanticscholar   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

Resolving the degree of order in the bacterial chromosome using a statistical physics approach [PDF]

arXiv, 2020
While bacterial chromosomes were long thought to be amorphous, recent experiments reveal pronounced organizational features. However, the extent of bacterial chromosome organization remains unclear. Here, we develop a fully data-driven maximum entropy approach to extract the distribution of single-cell chromosome conformations from experimental ...
arxiv  

Improving the Search by Encoding Multiple Solutions in a Chromosome [PDF]

Evolutionary Machine Design, Nova Science Publisher, New-York, edited by Nadia Nedjah (et al.), pp. 81-107, 2004, 2021
We investigate the possibility of encoding multiple solutions of a problem in a single chromosome. The best solution encoded in an individual will represent (will provide the fitness of) that individual. In order to obtain some benefits the chromosome decoding process must have the same complexity as in the case of a single solution in a chromosome ...
arxiv