Results 41 to 50 of about 6,792 (261)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Corporate Reputation and Users’ Behavioral Intentions: Is Reputation the Master Key That Moves Consumers?

SAGE Open, 2023
Despite the diverse perspectives on corporate reputation, few studies investigate consumers as a subject of corporate reputation. Thus, this study uncovers the factors that contribute to and comprise the reputation of mobile carriers, compares the ...
Mo Ran Yi
doaj   +1 more source

Corporate social responsibility and strengthening human talent in organizations

RHS Revista Humanismo y Sociedad, 2021
A successful organization must necessarily have a social responsibility strategy in place. In this sense, this research seeks to analyse the impact that corporate social responsibility has on strengthening human talent in organizations.
Luis Darío Canizales Muñoz
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Kurumsal Sosyal Sorumluluğun Satın Alma Niyeti Üzerindeki Etkisi: İstanbul İlinde Bir Araştırma

İstanbul Gelişim Üniversitesi Sosyal Bilimler Dergisi, 2017
Bu çalışmanın amacı, kurumsal sosyal sorumluluğun satın alma niyeti üzerindeki etkisinin belirlenmesidir. Bu amaçla tasarlanan araştırmada ekonomik, yasal, etik ve gönüllü sosyal sorumluluk ele alınmış, bu boyutlarla birlikte satın alma niyetini ölçen ...
İlknur Bilgen, Gülsüm Vezir Oğuz
doaj   +1 more source

DO MARKETS LOVE MISERY? STOCK PRICES AND CORPORATE PHILANTHROPIC DISASTER RESPONSE. [PDF]

Academy of Management Proceedings, 2008
This article discusses research into the social impact of corporate philanthropic disaster response (CPDR).
Muller, Alan, Kräussl, Roman
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effects of perceptions of corporate social performance on individual purchasing behaviour in South African university students: A mixed-method approach

South African Journal of Business Management, 2019
Background: Corporate social performance (CSP) has been widely researched in the past. However, few empirical studies, especially in the African context, have been conducted.
Roselyne Koech, David Coldwell
doaj   +1 more source

The Social Responsibility among Higher Education Students

Education Sciences, 2020
The aim of this research is to emphasize the importance of education for the philanthropic responsibilities of students. The basic term of the explanatory research is corporate social responsibility, adapted for higher education institutions—the ...
Emese Beáta Berei
doaj   +1 more source