Results 1 to 10 of about 10,861 (198)

Phage ImmunoPrecipitation Sequencing (PhIP-Seq): The Promise of High Throughput Serology [PDF]

Pathogens, 2022
Phage ImmunoPrecipitation Sequencing (PhIP-Seq) is a high throughput serological technology that is revolutionizing the manner in which we track antibody profiles. In this review, we mainly focus on its application to viral infectious diseases.
Charles Kevin Tiu, Feng Zhu, Lin-Fa Wang, Ruklanthi de Alwis   +3 more
doaj   +2 more sources

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq [PDF]

eLife, 2022
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood ...
Sara E Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F Kung, Zoe Quandt, Elise MN Ferré, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y Chan, Veronica M Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R Wilson, Olle Kämpe, Kerry Dobbs, Ottavia M Delmonte, Rosa Bacchetta, Luigi D Notarangelo, Jane C Burns, Jean-Laurent Casanova, Michail S Lionakis, Troy R Torgerson, Mark S Anderson, Joseph L DeRisi   +35 more
doaj   +2 more sources

Disposition and effects of alpha-pyrrolidinoisohexanophenone (α-PHiP) in comparison with cocaine: an observational study [PDF]

Frontiers in Pharmacology
IntroductionAlpha-pyrrolidinoisohexanophenone (α-PHiP) is a synthetic cathinone structurally related to alpha-pyrrolidinopentiophenone (α-PVP) and other pyrrolidinophenones, acting as a potent monoamine transporter inhibitor.
Georgina De la Rosa, Georgina De la Rosa, Giorgia Iacobone, Giorgia Iacobone, Esther Papaseit, Esther Papaseit, Esther Papaseit, Olga Hladun, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Dolly Andrea Caicedo, Martha Catalina Argote, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Alessandro Di Giorgi, Silvia Graziano, Simona Pichini, Emilia Marchei, Magí Farré, Magí Farré, Clara Pérez-Mañá, Clara Pérez-Mañá   +23 more
doaj   +2 more sources

Unraveling the relationships between processing conditions and PhIP formation in chemical model system and roast pork patty via principal component analysis

Food Chemistry: X
2-amino-1-methyl-6-phenylimidazole [4,5-b] pyridine (PhIP) is one of the higher levels of HAAs produced in protein foods during heating. The effects of heating temperature, time, and concentration of precursors on PhIP and related substances in the ...
Qi Chen, Yan Xu, Hao Dong, Weidong Bai, Xiaofang Zeng   +4 more
doaj   +2 more sources

PhIP-Seq: unveiling the complexity of antibody repertoires in health and disease [PDF]

Frontiers in Immunology
Phage-Immunoprecipitation Sequencing (PhIP-Seq) merges phage display with next-generation sequencing to enable high-throughput profiling of antibody repertoires.
Wenjie Tang, Qijing Gai, Junjie Yang, Jianqing Chen, Zhengbing Lyu   +4 more
doaj   +2 more sources

Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

Neoplasia, 2006
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) has been implicated as a major mutagenic heterocyclicamine in the human diet and is carcinogenic in the rat prostate.
Alexander D. Borowsky, Karen H. Dingley, Esther Ubick, Kenneth W. Turteltaub, Robert D. Cardiff, Ralph DeVere-White   +5 more
exaly   +3 more sources

Comorbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Chung‐Jansen Syndrome: Case Report and Review of Literature [PDF]

Clinical Case Reports
Chung‐Jansen Syndrome (CJS) is a rare autosomal dominant neurodevelopmental disorder caused by heterozygous mutations in the PHIP gene (6q14.1). It is characterized by developmental delay, intellectual disability, behavioral disturbances including autism
Maedeh Khalili, Maryam Yousefi Fahadani, Reza Bidaki, Zahra Talayi   +3 more
doaj   +2 more sources

Investigation of the dose and structure effects of lipid oxidation products aldehydes on the generation of heterocyclic amines: A case study of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) [PDF]

Food Chemistry: X
The effect of aldehydes from lipid oxidation on the generation of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) during pan-frying of golden pompano fillets was investigated.
Mantong Zhao, Zhongyuan Liu, Mengyin Zha, Ying Sun, Haohao Shi, Xueying Zhang, Chuan Li, Guanghua Xia   +7 more
doaj   +2 more sources

Development and Application of a Rapid Detection Technique for 2-Amino-1-methyl-6-phenyl-imidazo [4,5-b] Pyridine in Meat Products Based on Hydrogel-Molecular-Imprinting Electrochemical Sensing Technology [PDF]

Foods
2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP) is a harmful compound that is formed during the high-temperature processing of meat products, and the risk of cancer may be increased with the prolonged intake of foods containing high levels of ...
Chunxiao Li, Xiaolei Zhao, Xiaofei Yin, Shuting Zhang, Jinxing He   +4 more
doaj   +2 more sources

Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis.

PLoS ONE, 2013
Colorectal neoplasia is the third most common cancer worldwide. Environmental factors such as diet are known to be involved in the etiology of this cancer.
Emilien L Jamin, Anne Riu, Thierry Douki, Laurent Debrauwer, Jean-Pierre Cravedi, Daniel Zalko, Marc Audebert   +6 more
doaj   +3 more sources