Results 11 to 20 of about 13,902 (285)

PHIP-associated Chung-Jansen syndrome: Report of 23 new individuals [PDF]

Frontiers in Cell and Developmental Biology, 2023
In 2016 and 2018, Chung, Jansen and others described a new syndrome caused by haploinsufficiency of PHIP (pleckstrin homology domain interacting protein, OMIM *612,870) and mainly characterized by developmental delay (DD), learning difficulties ...
Antje Kampmeier, Elsa Leitão, Ilaria Parenti, Jasmin Beygo, Christel Depienne, Nuria C Bramswig, Tzung-Chien Hsieh, Alexandra Afenjar, Stefanie Beck-Wödl, Ute Grasshoff, Tobias B Haack, Emilia K Bijlsma, Claudia Ruivenkamp, Eva Lausberg, Miriam Elbracht, Maria K Haanpää, Maria K Haanpää, Hannele Koillinen, Hannele Koillinen, Uwe Heinrich, Imma Rost, Rami Abou Jamra, Denny Popp, Margarete Koch-Hogrebe, Kevin Rostasy, Vanesa López-González, Vanesa López-González, María José Sanchez-Soler, Catarina Macedo, Ariane Schmetz, Carmen Steinborn, Sabine Weidensee, Hellen Lesmann, Felix Marbach, Pilar Caro, Christian P. Schaaf, Peter Krawitz, Dagmar Wieczorek, Dagmar Wieczorek, Frank J Kaiser, Frank J Kaiser, Alma Kuechler, Alma Kuechler   +42 more
doaj   +9 more sources

Hydrogenative-PHIP polarized metabolites for biological studies [PDF]

Magnetic Resonance Materials in Physics, Biology and Medicine, 2021
ParaHydrogen induced polarization (PHIP) is an efficient and cost-effective hyperpolarization method, but its application to biological investigations has been hampered, so far, due to chemical challenges.
F. Reineri, E. Cavallari, Carla Carrera, S. Aime   +3 more
semanticscholar   +5 more sources

Effect of acrolein, a lipid oxidation product, on the formation of the heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in model systems and roasted tilapia fish patties

Food Chemistry: X, 2022
The effect of acrolein on the formation of the 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was investigated in a chemical model. Acrolein was found to increase PhIP formation at each tested addition level. 0–0.2 mmol of acrolein increased PhIP
Meilin Jing, Qingqing Jiang, Yamin Zhu, Daming Fan, Mingfu Wang, Yueliang Zhao   +5 more
doaj   +2 more sources

phippery: a software suite for PhIP-Seq data analysis

Bioinformatics, 2023
Summary We present the phippery software suite for analyzing data from phage display methods that use immunoprecipitation and deep sequencing to capture antibody binding to peptides, often referred to as PhIP-Seq. It has three main components that can be
Jared G. Galloway, K. Sung, Samuel S. Minot, M. Garrett, Caitlin I. Stoddard, Alexandra C. Willcox, Zak A. Yaffe, Ryan Yucha, J. Overbaugh, Frederick Albert Matsen IV   +9 more
semanticscholar   +3 more sources

Effect and mechanism of polyphenols containing m-dihydroxyl structure on 2-amino-1-methyl-6-phenylimidazole [4, 5-b] pyridine (PhIP) formation in chemical models and roast pork patties

Food Chemistry: X
2-amino-1-methyl-6-phenylimidazole [4, 5-b] pyridine (PhIP) is a prevalent heterocyclic amine (HAA) found in heated processed meat. This study investigated the inhibitory impact of eight different types of polyphenols containing m-dihydroxyl structure on
Hao Dong, Qi Chen, Yan Xu, Chao Li, Weidong Bai, Xiaofang Zeng, Qingping Wu, Huan Xu, Jinhua Deng   +8 more
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LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter

BMC Cancer, 2023
Background Long non-coding RNAs play an important role in the development of colorectal cancer (CRC), while many CRC-related lncRNAs have not yet been identified.
Ganglin Ren, Hongyan Li, Dan Hong, Fangyu Hu, Rongjia Jin, Shuang Wu, Wenhao Sun, Honglei Jin, Lingling Zhao, Xiaodong Zhang, Dongxiang Liu, Chuanshu Huang, Haishan Huang   +12 more
doaj   +2 more sources

PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis

Biology, 2022
Enteroviruses such as group B coxsackieviruses (CVB) are commonly suspected as causes of myocarditis that can lead to dilated cardiomyopathy (DCM), and the mouse model of CVB3 myocarditis is routinely used to understand DCM pathogenesis. Mechanistically,
Mahima T. Rasquinha, Ninaad Lasrado, Erika Petro-Turnquist, Eric Weaver, Thiagarajan Venkataraman, Daniel Anderson, Uri Laserson, H. Benjamin Larman, Jay Reddy   +8 more
doaj   +2 more sources

PhIP-Seq: methods, applications and challenges

Frontiers in Bioinformatics
Phage-immunoprecipitation sequencing (PhIP-Seq) technology is an innovative, high-throughput antibody detection method. It enables comprehensive analysis of individual antibody profiles.
Ziru Huang, Samarappuli Mudiyanselage Savini Gunarathne, Wenwen Liu, Yuwei Zhou, Yuqing Jiang, Shiqi Li, Jian Huang, Jian Huang   +7 more
doaj   +3 more sources

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

Chemistry – An Asian Journal, 2018
The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules.
Kirill V. Kovtunov, Ekaterina V. Pokochueva, Oleg G. Salnikov, Samuel F. Cousin, Dennis Kurzbach, Basile Vuichoud, Sami Jannin, Eduard Y. Chekmenev, Boyd M. Goodson, Danila A. Barskiy, Igor V. Koptyug   +10 more
semanticscholar   +7 more sources

Pd-based bimetallic catalysts for parahydrogen-induced polarization in heterogeneous hydrogenations [PDF]

Magnetic Resonance, 2021
Production of hyperpolarized catalyst-free gases and liquids by heterogeneous hydrogenation with parahydrogen can be useful for various technical as well as biomedical applications, including in vivo studies, investigations of mechanisms of industrially ...
D. B. Burueva, D. B. Burueva, A. Y. Stakheev, I. V. Koptyug, I. V. Koptyug   +4 more
doaj   +2 more sources