Results 231 to 240 of about 13,902 (285)

Simultaneous determination of the PhIP-proline adduct and related precursors by UPLC-MS/MS for confirmation of direct elimination of PhIP by proline

Food Chemistry, 2021
Zhiyong He, Zhaojun Wang, Fatih Oz
exaly   +2 more sources

Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription

Cell Metabolism, 2020
Summary Obesity is genetically heterogeneous with monogenic and complex polygenic forms. Using exome and targeted sequencing in 2,737 severely obese cases and 6,704 controls, we identified three genes (PHIP, DGKI, and ZMYM4) with an excess burden of very
Gaelle Marenne, Audrey E Hendricks, Aliki Perdikari   +2 more
exaly   +2 more sources

Synergistic Inhibitory Effects of Selected Amino Acids on the Formation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in both Benzaldehyde- and Phenylacetaldehyde-Creatinine Model Systems.

Journal of Agricultural and Food Chemistry, 2022
Although various inhibitors have been employed to react with phenylacetaldehyde to form adducts and thus interrupt the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), high concentrations of PhIP remain in the final system. It remains
Peng Deng, Chaoyi Xue, Zhiyong He, Zhaojun Wang, Fang Qin, E. Oz, Jie Chen, A. E. El Sheikha, Charalampos Proestos, F. Oz, Maomao Zeng   +10 more
semanticscholar   +1 more source

PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Glioblastoma has an extremely poor prognosis, driven by its invasive and angiogenic potential. The development of effective therapies for glioblastoma will require the identification of molecular factors that promote these hallmarks.
Mehdi Nosrati, Jonathon Judkins, Altaf A Dar   +2 more
exaly   +2 more sources

Formation and Prediction of PhIP, Harman, and Norharman in Chemical Model Systems Containing Epicatechin under Various Reaction Conditions.

Journal of Agricultural and Food Chemistry, 2021
The aim of this study was to investigate the formation rules of 1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), 1-methyl-9H-pyrido[3,4-b]-indole (Harman), and 9H-pyrido[3,4-b]-indole (Norharman) in chemical model systems containing epicatechin under ...
Teng Hui, Yanlei Li, Ruixia Chen, Xiaoyue Yang, Huan Liu, Zhenyu Wang, Dequan Zhang   +6 more
semanticscholar   +1 more source

Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.

Food and Chemical Toxicology, 2021
The present study investigated the protective effects and mechanism of action of cyanidin-3-O-glucoside (C3G) and its major metabolite protocatechuic acid (PCA) against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 ...
Lei Zhao, Na Zhou, Huimin Zhang, Fei Pan, Xin Ai, Yong Wang, Shuai Hao, Chengtao Wang   +7 more
semanticscholar   +1 more source

The inhibitory effects of yellow mustard (Brassica juncea) and its characteristic pungent ingredient allyl isothiocyanate (AITC) on PhIP formation: Focused on the inhibitory pathways of AITC.

Food Chemistry, 2021
The effects of yellow mustard (Brassica juncea) and its characteristic component allyl isothiocyanate (AITC) on the formation of 2-amino-y1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in roast beef patties and PhIP-producing model systems were ...
Liwen Jiang, Yong Li, Chaoyi Xue, Zhiyong He, Zhaojun Wang, Fang Qin, Jie Chen, Maomao Zeng   +7 more
semanticscholar   +1 more source

Sub-chronic exposure to PhIP induces oxidative damage and DNA damage, and disrupts the amino acid metabolism in the colons of Wistar rats.

Food and Chemical Toxicology, 2021
Heterocyclic amines (HCAs) are a group of mutagenic compounds produced during thermal processing of protein-rich foods. One of the most abundant HCAs, 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) has potential carcinogenic and mutagenic ...
Xiuli Zhao, Zeping Shao, Xiaofei Zhou, Yong-Yang Lin, Jing Guo, Jun Guo, Yan Zhang, Shuo Wang   +7 more
semanticscholar   +1 more source

Effects of the Deacetylation Degree of Chitosan on 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Formation in Chemical Models and Beef Patties.

Journal of Agricultural and Food Chemistry, 2021
The effects of the deacetylation degree (DD) of chitosan on heterocyclic aromatic amine formation were investigated in chemical models and beef patties.
Yueliang Zhao, Hongmei Yang, Nana Zhang, Qian Zhou, D. Fan, Mingfu Wang   +5 more
semanticscholar   +1 more source

Combination of OPSY and PhD-PHIP results in enhanced sensitivity in PHIP

Journal of Magnetic Resonance, 2019
Despite the large degree of polarization in PHIP experiments compared to the Boltzmann factor, the presence of a large amount of non-reacted molecules with thermal polarization is an important obstacle when dealing with very diluted samples. The feasibility of enhancing both sensitivity and resolution in a single experiment by combining two well ...
Bussandri Mattia, Santiago, Buljubasich Gentiletti, Lisandro, Acosta, Rodolfo Héctor   +2 more
openaire   +3 more sources