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The dietary carcinogen PhIP activates p53‐dependent DNA damage response in the colon of CYP1A‐humanized mice

Biofactors, 2021
Species differences in the metabolism of xenobiotics by cytochrome P450 are critical in evaluating the use of experimental animals in studying toxic compounds relevant to human diseases.
Xu Yang   +6 more
semanticscholar   +1 more source

Inhibitory effect of selected hydrocolloids on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) formation in chemical models and beef patties.

Journal of Hazardous Materials, 2020
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagen and a rodent carcinogen mainly formed in thermally processed muscle foods. Hydrocolloids are widely used as thickeners, gelling agents and stabilizers to improve food quality in the food
Hongmei Yang   +5 more
semanticscholar   +1 more source

Diffusion measurements with continuous hydrogenation in PHIP

Journal of Magnetic Resonance, 2020
DOSY is a powerful spectroscopic NMR technique that resolves components in mixtures through the evaluation of different diffusion coefficients. The application of DOSY to dilute mixtures is hampered by the low signal to noise ratios (SNR), leading to long acquisition times.
Bussandri Mattia, Santiago   +2 more
openaire   +3 more sources

Simultaneous Analysis of PhIP, 4′-OH-PhIP, and Their Precursors Using UHPLC–MS/MS

Journal of Agricultural and Food Chemistry, 2014
A novel method allowing simultaneous analysis of PhIP, 4'-OH-PhIP, and their precursors (phenylalanine, tyrosine, creatine, creatinine, glucose) has been developed as a robust kinetic study tool by using ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
Yan, Yan   +7 more
openaire   +2 more sources

Novel hydrocolloids synthesized by polyphenols grafted onto chitosan: A promising coating to inhibit PhIP formation during pan-frying of golden pompano fillets.

Food Chemistry
Hydrocolloids synthesized by gallic acid (GA) and ferulic acid (FA) grafting onto chitosan (CS) were characterized, and their effects on PhIP formation in pan-fried golden pompano were investigated.
Mantong Zhao   +7 more
semanticscholar   +1 more source

A novel potent inhibitor of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) formation from Chinese chive: Identification, inhibitory effect and action mechanism.

Food Chemistry, 2020
Differential solvent extraction and phytochemical profiling of Chinse chive were employed to identify its principal PhIP-formation inhibitory constituents. Six compounds (mangiferin, isorhamnetin, luteolin, rosmarinic acid, 6-methylcoumarin, and cyanidin-
Qi Wang   +7 more
semanticscholar   +1 more source

Caffeic acid assists microwave heating to inhibit the formation of mutagenic and carcinogenic PhIP.

Food Chemistry, 2020
The inhibitory effect of caffeic acid on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) was investigated in chemical model systems under microwave heating (MW).
Nana Zhang   +9 more
semanticscholar   +1 more source

Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP–DNA adduct formation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003
The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct formation and its mechanism were studied. Rats were exposed to freshly prepared aqueous extracts of green tea (3% (w/v)) as the sole source of drinking water for 10 days prior to administration with a single dose of PhIP (10 mg/kg body weight) by
Dong-Xin, Lin   +4 more
openaire   +2 more sources

The Rise of William Phips

The New England Quarterly, 1928
T HE American tradition of the poor boy who becomes rich through hard work, native ability, and good luck, is older than one suspects. Any one with imagination can discern unknown Rockefellers in the dry records of colonial estates, land titles, and assessments. Little imagination is required to reconstruct the story of William Phips. His career in the
openaire   +1 more source

Validation in rats of two biomarkers of exposure to the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP): PhIP-DNA adducts and urinary PhIP

Carcinogenesis, 1996
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in white blood cells and tissues and unmetabolized PhIP in urine were validated as biomarkers of exposure in male Fischer-344 rats treated with daily PhIP doses ranging from 1 to 0.0001 mg/kg.
Friesen, M.   +5 more
openaire   +3 more sources

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