Results 31 to 40 of about 13,902 (285)

Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness. [PDF]

Genes Dev
Pawar AS, Somers P, Alex A, Grana J, Feist VK, George SS, Jalnapurkar SS, Antony C, Verner R, White-Brown SK, Khera M, Mendoza-Figueroa MS, Liu KF, Morrissette JJD, Gurbuxani S, Paralkar VR.   +15 more
europepmc   +3 more sources

Polarization transfer efficiency in PHIP experiments

Physical Chemistry Chemical Physics, 2017
We present a novel method, based on kinetic investigations, for the determination of the polarization transfer efficiency in PHIP experiments.
Meike Emondts, Johannes F. P. Colell, Bernhard Blümich, P. Philipp M. Schleker   +3 more
openalex   +6 more sources

Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli. [PDF]

PLoS ONE, 2013
The heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-B]pyridine (PhIP), found in meats cooked at high temperatures, has been implicated in epidemiological and rodent studies for causing breast, prostate, and colorectal cancers.
Kirstie Canene-Adams, Karen S Sfanos, Chung-Tiang Liang, Srinivasan Yegnasubramanian, William G Nelson, Cory Brayton, Angelo M De Marzo   +6 more
doaj   +1 more source

Methodical approach for determination of the heterocyclic aromatic amines in meat products using HPLC–MS/MS

Теория и практика переработки мяса, 2021
Heterocyclic aromatic amines (HAA) are formed in foods of animal origin during the Maillard reaction due to the high creatine and creatinine contents. HAA have carcinogenic and mutagenic effects.
D. A. Utyanov, A. V. Kulikovskii, A. S. Knyazeva, A. A. Kurzova, A. N. Ivankin   +4 more
doaj   +1 more source

A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer

Genes & Development, 2021
In this study, Morgan et al. investigated how the PHIP/BRWD2 chromatin regulator functions in human neurodevelopmental disorders and cancer, and demonstrate that PHIP is a chromatin-associated CRL4 ubiquitin ligase substrate receptor and is required for ...
M. Morgan, Irina K. Popova, Anup Vaidya, J. Burg, M. Marunde, E. Rendleman, Zach Dumar, Rachel Watson, Matthew J. Meiners, S. A. Howard, Natalia Khalatyan, R. M. Vaughan, S. Rothbart, M. Keogh, A. Shilatifard   +14 more
semanticscholar   +1 more source

Establishment of Novel Genotoxicity Assay System Using Murine Normal Epithelial Tissue-Derived Organoids

Frontiers in Genetics, 2021
Short-/middle-term and simple prediction studies for carcinogenesis are needed for the safety assessment of chemical substances. To establish a novel genotoxicity assay with an in vivo mimicking system, we prepared murine colonic/pulmonary organoids from
Masami Komiya, Rikako Ishigamori, Mie Naruse, Masako Ochiai, Noriyuki Miyoshi, Toshio Imai, Toshio Imai, Yukari Totsuka, Yukari Totsuka   +8 more
doaj   +1 more source

Urinary N2-(2'-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure [PDF]

Carcinogenesis, 2004
The food-derived, heterocyclic aromatic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is genotoxic and is carcinogenic in experimental animals. Studies on the role of PhIP in human diet-related cancer would be aided considerably by the availability of a readily applicable biomarker of the internal dose of the ultimate genotoxic species ...
Min, Fang, Robert J, Edwards, Michael, Bartlet-Jones, Graham W, Taylor, Stephen, Murray, Alan R, Boobis   +5 more
openaire   +2 more sources

Detecting antibody reactivities in Phage ImmunoPrecipitation Sequencing data

BMC Genomics, 2022
Phage ImmunoPrecipitation Sequencing (PhIP-Seq) is a recently developed technology to assess antibody reactivity, quantifying antibody binding towards hundreds of thousands of candidate epitopes.
Athena Chen, Kai Kammers, H Benjamin Larman, Robert B. Scharpf, Ingo Ruczinski   +4 more
doaj   +1 more source

Hipsters on Networks: How a Small Group of Individuals Can Lead to an Anti-Establishment Majority [PDF]

, 2018
The spread of opinions, memes, diseases, and "alternative facts" in a population depends both on the details of the spreading process and on the structure of the social and communication networks on which they spread.
Juul, Jonas S., Porter, Mason A.
core   +2 more sources

Syntactic Doubling and the Structure of Chains [PDF]

, 2008
A recent survey of 267 dialects of Dutch (SAND; Barbiers et al.
Barbiers, S., Koeneman, O.N.C.J., Lekakou, M.   +2 more
core   +3 more sources