Results 71 to 80 of about 13,902 (285)

Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

Advanced Science, 2023
Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment
Luca Nagel, Martin Gierse, Wolfgang Gottwald, Zumrud Ahmadova, Martin Grashei, Pascal Wolff, Felix Josten, Senay Karaali, Christoph A. Müller, Sebastian Lucas, Jochen Scheuer, Christoph Müller, John Blanchard, Geoffrey J. Topping, Andre Wendlinger, Nadine Setzer, Sandra Sühnel, Jonas Handwerker, Christophoros Vassiliou, Frits H.A. vanHeijster, Stephan Knecht, Michael Keim, Franz Schilling, Ilai Schwartz   +23 more
doaj   +1 more source

Hyphenation of 2D NMR With Hydrogenative PHIP [PDF]

Magnetic Resonance in Chemistry
ABSTRACTParahydrogen induced polarisation (PHIP) is often used to enhance the sensitivity of NMR, with the purpose of extending the applicability of the technique. Nuclear spin hyperpolarisation obtained via PHIP is generally localised on the protons derived from the addition of para‐enriched hydrogen to an unsaturated substrate.
Jimmink, Bono O., Tessari, Marco, Kentgens, Arno P. M.   +2 more
openaire   +3 more sources

From binaries to multiples I: Data on F and G dwarfs within 67 pc of the Sun

, 2014
Data on the multiplicity of F- and G-type dwarf stars within 67pc of the Sun are presented. This distance-limited sample based on the Hipparcos catalog contains 4847 primary stars (targets) with 0.590% complete.
Tokovinin, Andrei
core   +1 more source

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

Advances in Parahydrogen‐Induced Polarization for Nuclear Magnetic Resonance of Peptides, Proteins, and Biopolymers

ChemistryEurope, EarlyView.
Hyperpolarization by parahydrogen‐induced polarization enhances the sensitivity of nuclear magnetic resonance spectroscopy of amino acids, peptides, mini‐proteins, and biopolymers using nonnatural amino acids with unsaturated side chains up to three orders of magnitude.
Gerd Buntkowsky
wiley   +1 more source

Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice. [PDF]

PLoS ONE, 2012
Epidemiological studies suggest that mushroom intake is inversely correlated with gastric, gastrointestinal and breast cancers. We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma
Daniel Sliva, Jagadish Loganathan, Jiahua Jiang, Andrej Jedinak, John G Lamb, Colin Terry, Lee Ann Baldridge, Jiri Adamec, George E Sandusky, Shailesh Dudhgaonkar   +9 more
doaj   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network [PDF]

, 2020
Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins is emerging as a promising therapeutic strategy. Despite intense efforts to rationally design degrader molecules that co-opt CRL4s, much about the organization and ...
den Besten, Willem, Deshaies, Raymond J., Hinkle, Trent, Kirkpatrick, Donald S., Moradian, Annie, Petzold, Georg, Reichermeier, Kurt M., Reitsma, Justin M., Rose, Christopher M., Straube, Ronny, Sweredoski, Michael J., Thomä, Nicolas H., Verschueren, Erik, Wertz, Ingrid E.   +13 more
core  

Growth and survival of probiotic lactic acid bacteria in the presence of heterocyclic aromatic amines [PDF]

, 2014
Heterocyclic aromatic amines (HCAs) ingested with heat-processed meat can contribute to colon cancer development. Those compounds interact with human intestinal microbiota.
Nowak, Adriana
core   +1 more source

Current state of the art of analyte scope in urine metabolome analysis by non-hydrogenative PHIP

Journal of Magnetic Resonance Open
Non-hydrogenative PHIP (nh-PHIP) is an NMR signal enhancement technique that offers several orders of magnitude gains in detection sensitivity. It is one of the few hyperpolarization methods that have been demonstrated to be applicable to chemical ...
Nele Reimets, Kerti Ausmees, Indrek Reile   +2 more
doaj   +1 more source