Results 61 to 70 of about 976 (137)

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Phlebotominae spatial distribution asssociated with a focus of tegumentary leishmaniasis in Las Lomitas, Formosa, Argentina, 2002

Memorias do Instituto Oswaldo Cruz, 2006
Las Lomitas, Formosa, Argentina, reported 96 cases of tegumentary leishmaniasis during 2002. The urban transmission was suggested although previous outbreaks were related with floods of the Bermejo river (BR) 50 km from the village.
Oscar Daniel Salomón, Pablo Wenceslao Orellano, Mario Lamfri, Marcelo Scavuzzo, Lucía Dri, María Isabel Farace, Darío Ozuna Quintana   +6 more
doaj   +1 more source

Exploring Novel Nitrofuryl‐1,3,4‐Thiadiazole‐Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
In a series of substituted 1‐[5‐(5‐nitrofuran‐2‐yl)‐1,3,4‐thiadiazol‐2‐yl]piperidine‐4‐carboxamides evaluated for in vitro antileishmanial and antitrypanosomal activity, compound 18 emerged as the most promising derivative, showing submicromolar anti‐parasitic effects targeting diverse Leishmania and Trypanosoma species and acceptable selectivity ...
Alireza Mousavi, Martina Slapničková, Maryam Norouzbahari, Sarah D'Alessandro, Parham Foroumadi, Fariba Peytam, Federica Perego, Eva Doleželová, Zahra Emamgholipour, Maliheh Barazandeh Tehrani, Seyed Esmaeil Sadat‐Ebrahimi, Elahe Hosseinzadeh, Elmira Meghrazi Ahadi, Loghman Firoozpour, Hamidreza Bijanzadeh, Nicoletta Basilico, Alena Zíková, Alireza Foroumadi   +17 more
wiley   +1 more source

Angiopoietin‐1, Angiopoietin‐2 and Vascular Endothelial Growth Factor Levels in Canine Leishmaniosis

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Ang‐1, Ang‐2 and VEGF levels significantly varied in different stages of canine leishmaniosis. ABSTRACT Background Canine leishmaniosis (CanL) is a zoonotic vector–borne disease and is primarily associated with systemic inflammation, endothelial dysfunction and immune dysregulation.
Gamze Gultekin, Erdogan Malatyali, Evren Tileklioglu, Hatice Ertabaklar, Songul Erdogan, Gamze Sevri Ekren Asici, Asude Gulce Oryasin, Serdar Pasa, Kerem Ural, Hasan Erdogan, Mehmet Gultekin   +10 more
wiley   +1 more source

Susceptibility of phlebotomine sandflies (Diptera: Psychodidae) collected in the field, to alpha-cypermethrin in four municipalities endemic to leishmaniasis

Revista do Instituto de Medicina Tropical de São Paulo
Although the chemical control against leishmaniasis began in 1953 in Brazil, little information is available on how this strategy has affected populations of phlebotomine sandflies in the field.
Douglas de Almeida Rocha, Andrey José de Andrade, Luciana Reinaldo Moura, Nelder Gontijo Figueiredo, Grasielle Caldas D’Ávila Pessoa, Marcos Takashi Obara   +5 more
doaj   +1 more source

Effect of deltamethrin spraying on the sandfly populations in a focus of American cutaneous leismaniasis

Memorias do Instituto Oswaldo Cruz, 1991
The effect of deltamethrin of the sandfly population in a focus of American Cutaneous Leishmaniasis in Viana, Espírito Santo State is desvribed. The phlebotomine population density was determined inside and outside houses during a one year period in a ...
Alda Lima Falcão, Alberto Rocha Falcão, Claudio Teixeira Pinto, Célia Maria Ferreira Gontijo, Aloísio Falqueto   +4 more
doaj   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis.

PLoS Neglected Tropical Diseases, 2019
Leishmaniasis is a zoonotic disease of worldwide relevance. Visceral leishmaniasis is endemic in Brazil, where it is caused by Leishmania infantum with Lutzomyia longipalpis being the most important invertebrate vector. Non-human primates are susceptible
Ayisa Rodrigues de Oliveira, Guilherme Rafael Gomide Pinheiro, Herlandes P Tinoco, Maria Elvira Loyola, Carlyle Mendes Coelho, Edelberto Santos Dias, Érika Michalsky Monteiro, Fabiana de Oliveira Lara E Silva, Angela Tinoco Pessanha, Andreza Geisiane Maia Souza, Nathália Cristina Lima Pereira, Nelder F Gontijo, Ricardo T Fujiwara, Tatiane Alves da Paixão, Renato Lima Santos   +14 more
doaj   +1 more source

Species and public health relevance of Phlebotomine sand flies (Diptera: Psychodidae: Phlebotominae) in an endemic area of tegumentary leishmaniasis in southeastern Brazil [PDF]

Ciência Rural
: Phlebotomine sand flies (Diptera: Psychodidae: Phlebotominae) are small dipterans of significant public health importance, as they serve as vectors mainly for Leishmania spp. protozoa in humans and animals.
Pedro Armando Meneghesso, Jéssica de Moraes Santana, Artur Yuiti Shimada de Carvalho, João Augusto Franco Leonel, Beatriz Augusta Pereira, Julia Cristina Benassi, Trícia Maria Ferreira de Sousa Oliveira   +6 more
doaj   +2 more sources

Leishmania DNA detection and species characterization within phlebotomines (Diptera: Psychodidae) from a peridomicile-forest gradient in an Amazonian/Guianan bordering area.

PLoS ONE, 2019
In the border region between Brazil and French Guiana, American cutaneous leishmaniasis is a worrisome public health issue, and entomological studies are required there to better identify classical and putative emerging transmission patterns. The present
Thiago Vasconcelos Dos Santos, Daniela de Pita-Pereira, Thais Araújo-Pereira, Constança Britto, Fernando Tobias Silveira, Marinete Marins Póvoa, Elizabeth Ferreira Rangel   +6 more
doaj   +1 more source