Results 41 to 50 of about 4,836 (180)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Bartonella spp. in Phlebotominae Sand Flies, Brazil

Emerging Infectious Diseases
Bartonella spp. are opportunistic, vectorborne bacteria that can cause disease in both animals and humans. We investigated the molecular occurrence of Bartonella spp.
Daniel Antônio Braga Lee, Paloma Helena Fernandes Shimabukuro, Andréia Fernandes Brilhante, Paulo Vitor Cadina Arantes, Gustavo Seron Sanches, Eliz Oliveira Franco, Rosangela Zacarias Machado, Ricardo G. Maggi, Edward B. Breitschwerdt, Marcos Rogério André   +9 more
doaj   +1 more source

Phlebotomine sand flies in Porteirinha, an area of American visceral leishmaniasis transmission in the State of Minas Gerais, Brazil

Memorias do Instituto Oswaldo Cruz, 2004
A study of the phlebotomine sand fly fauna was carried out in an endemic area of American visceral leishmaniasis (AVL) in the municipality of Porteirinha, in the Brazilian state of Minas Gerais. Captures were performed with CDC light traps in 7 districts,
Ricardo Andrade Barata, João Carlos França da Silva, Roberto Teodoro da Costa, Consuelo Latorre Fortes-Dias, Jaime Costa da Silva, Edvá Vieira de Paula, Aluízio Prata, Érika Michalsky Monteiro, Edelberto Santos Dias   +8 more
doaj   +1 more source

Investigation of natural infection of Phlebotomine (Diptera: Psychodidae) by Leishmania in Tunisian endemic regions

Parasite Epidemiology and Control, 2021
Leishmaniases are caused by protozoan parasites of the genus Leishmania transmitted by females blood-feeding phlebotomine insects (Diptera: Psychodidae). In Tunisia, cutaneous and visceral leishmaniases are of public health concern.
Melek Chaouch, Amal Chaabane, Chiraz Ayari, Souad Ben Othman, Denis Sereno, Jomaa Chemkhi, Souha BenAbderrazak   +6 more
doaj   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

First inventory of the sandfly fauna (Diptera: Psychodidae, Phlebotominae) in the municipality of Juiz de Fora, State of Minas Gerais, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2014
Introduction: This study aimed to inventory the phlebotomine sandfly fauna present in the urban area of Juiz de Fora, with an emphasis on the genus Lutzomyia.
Izabella de Oliveira Pinheiro, Milton Ferreira de Castro, Murilo Gonçalves, Adilson da Costa Lima, Glênia Maria de Magalhães Campos, Adalberto Mitterofhe, Ricardo José de Paula Souza e Guimarães, José Dilermando Andrade Filho, Elaine Soares Coimbra   +8 more
doaj   +1 more source

Phlebotomine fauna in a rural area of the Brazilian Pantanal [PDF]

Revista de Saúde Pública, 2006
The aim of the study was to identify among the phlebotomine fauna potential leishmaniasis vectors. The study was carried out in Corumbá county, State of Mato Grosso do Sul, Mid-West Brazil (18º59'S, 56º39'W). Sand fly captures were undertaken fortnightly with automatic light traps at 11 sites in forested environments and anthropic areas from April 2001
Braga-Miranda, Lourdislene Costa, Miranda, Marcos, Galati, Eunice A Bianchi   +2 more
openaire   +5 more sources

Visceral Leishmaniasis in Somalia: Diagnosis and Management of a Classic Case in a Resource‐Limited Endemic Setting

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Visceral Leishmaniasis (VL), a severe systemic neglected tropical disease (NTD) caused by Leishmania donovani complex protozoa, poses a significant public health threat, particularly in East Africa, where it is fatal if untreated. Somalia is known to be endemic, but the true burden and programmatic challenges are poorly documented due to long ...
Abdirahman Nuur Hussein, Abdirahman Omer Ali, Ridwan Zakariye Ahmed, Sihaam Mohamed Abdirahman, Ahmed Dek Abdiwahab   +4 more
wiley   +1 more source

The Regulatory Effect of Histone Deacetylase (HDAC) 1 and 2 on iNOS, IL‐6, TNF‐α and IL‐10 Expression in Canine Macrophages Infected With Leishmania infantum

Parasite Immunology, Volume 48, Issue 4, April 2026.
ABSTRACT Zoonotic visceral leishmaniasis is caused by Leishmania (Leishmania) infantum. Dogs are considered the most critical urban reservoirs of L. (L.) infantum due to their high infection rate and direct transmission to humans. The parasite has developed mechanisms to evade the host's defence system by inhibiting macrophage activation, thereby ...
Gabriela Lovizutto Venturin, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Gabriela Torres Rebech, Flávia Lombardi Lopes, Valéria Marçal Felix de Lima   +5 more
wiley   +1 more source

[Phlebotomine sandflies of Southern Brazil].

Revista de saude publica, 2005
OBJECTIVE: To identify the sandfly fauna and some aspects of their behavior in forest and anthropic environments. METHODS: Sandfly captures were undertaken in farm (23º 6' S; 50º 22' W), in Southern Brazil. Falcão light traps were set in forest, domicile and domestic animal shelters and mosquitoes were collected monthly, between 17h and 7h, from March ...
Massafera, Rubens, Silva, Allan Martins da, Carvalho, Antônio Plácido de, Santos, Demilson Rodrigues dos, Galati, Eunice Aparecida Bianchi, Teodoro, Ueslei   +5 more
openaire   +2 more sources