Results 101 to 110 of about 1,424,154 (388)
Frontiers in Marine Science, 2020 Coastal ecosystems are subject to human impacts both through adjacent lands and by run-off from the broader catchment area. Nutrient inputs, like phosphorus, were often lowered decades ago, but many aquatic ecosystems have not recovered accordingly ...
Maximilian Berthold, Rhena Schumann
doaj +1 more source
Pyruvate kinase phosphatase [PDF]
FEBS Letters, 1981 1. Introduction Liver pyruvate kinase can be phosphorylated and simultaneously inactivated by CAMP-dependent pro- tein kinase; the inactivated enzyme can be reactivated by a multifunctional protein phosphatase (review [ 13). The inactivation of pyruvate kinase has been observed in isolated hepatocytes incubated in the presence of glucagon and in this ...
Mary-Frances Jett +2 more
openaire +3 more sources
Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate [PDF]
, 2013 Cellular decision-making is driven by dynamic behaviours, such as the preparations for sunrise enabled by circadian rhythms and the choice of cell fates enabled by positive feedback.
Mac Gabhann, Feilim +2 more
core +3 more sources
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Intestinal alkaline phosphatase: novel functions and protective effects.
Nutrition reviews, 2014 Important protective roles of intestinal alkaline phosphatase (IAP)--including regulation of intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial lipopolysaccharide, attenuation of intestinal inflammation, and ...
J. Lallès
semanticscholar +1 more source
Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model [PDF]
, 2010 Keeping in view the ever increasing problem of drug resistance and affordability of the antimalarial drugs by the poor mass, herbal medicines can become an important and alternative sustainable strategy for malaria treatment.
Chinmoy Karjee +11 more
core +1 more source
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes. [PDF]
, 2018 Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors ...
Beckendorf, Lisa +10 more
core +3 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Frontiers in Plant Science, 2020 Limited P availability in several agricultural areas is one of the key challenges facing current agriculture. Exploiting P-solubilizing bacteria (PSB) has been an emerging bio-solution for a higher rhizosphere P-availability, meanwhile the above- and ...
Wissal Elhaissoufi +9 more
doaj +1 more source
Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin [PDF]
, 2018 Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase ...
Baucum, Anthony J., II +6 more
core +1 more source