Results 121 to 130 of about 1,448,184 (405)

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

Molecular Systems Biology, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel, Thomas G Graeber   +12 more
doaj   +1 more source

Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling

Frontiers in Plant Science, 2018
Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs).
Lingyan Jiang, Lingyan Jiang, Yinhua Chen, Yinhua Chen, Lijuan Luo, Lijuan Luo, Scott C. Peck, Scott C. Peck, Scott C. Peck   +8 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

And the winner is … the phosphatase!

The Journal of Cell Biology, 2002
![Graphic][1] Predicted time course of kinase i activity. Heinrich/ElsevierSignaling pathways can be a dizzying confusion of interlacing kinases, phosphatases, activators, and inhibitors.
openaire   +2 more sources

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Four tillage method assessments on soil organic carbon, total nitrogen, biological activities, and maize grain yield in Southern China

Food and Energy Security, 2019
Creating a soil habitat is the first step to manage soil health for long‐term soil quality and output. This means using soil management methods that lessen the soil uproar.
Evans Asenso, Lian Hu, Fuseini Issaka, Kai Tian, Lina Zhang, Luyong Zhang, Jiefeng Zeng, Yan‐Fei Zhu, Jiuhao Li   +8 more
doaj   +1 more source

Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis

Cells, 2019
Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis.
Meghna Kataria, Hiroyuki Yamano
doaj   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Cerium Oxide Nanoparticles Role as Antioxidant

Medical Journal of Babylon
Cerium oxide nanoparticles (NPs), also known as ceria NPs, are particles of cerium oxide with sizes in the nanometer range. Cerium oxide (CeO2) is a compound composed of cerium and oxygen, and when it is reduced to NPs, it exhibits unique properties and ...
Sura A. Abdulsattar
doaj   +1 more source

A HISTOCHEMICAL STUDY OF "ACID" AND "ALKALINE" PHOSPHATASE DISTRIBUTION IN NORMAL HUMAN BONE MARROW SMEARS [PDF]

, 1949
M. Rabinovitch, Domingos Andreucci
openalex   +1 more source