Results 121 to 130 of about 1,127,331 (318)
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
Molecular Systems Biology, 2012 The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Nicholas A Graham +12 more
doaj +1 more source
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 Reversible protein phosphorylation is known to play important roles in the regulation of various cellular processes in eukaryotes. Phosphatase-mediated dephosphorylation are integral components of cellular signal pathways by counteracting the ...
Guang Yang +8 more
doaj +1 more source
Cellular signaling networks function as generalized Wiener-Kolmogorov filters to suppress noise [PDF]
arXiv, 2014 Cellular signaling involves the transmission of environmental information through cascades of stochastic biochemical reactions, inevitably introducing noise that compromises signal fidelity. Each stage of the cascade often takes the form of a kinase-phosphatase push-pull network, a basic unit of signaling pathways whose malfunction is linked with a ...
arxiv
Advanced Biology, EarlyView.The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez +8 more
wiley +1 more source
Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis [PDF]
, 2007 During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Baum, B +4 more
core
Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin [PDF]
, 2018 Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase ...
Baucum, Anthony J., II +6 more
core +1 more source
Multiple steady states and the form of response functions to antigen in a model for the initiation of T cell activation [PDF]
arXiv, 2017 The aim of this paper is to study the qualitative behaviour predicted by a mathematical model for the initial stage of T cell activation. The state variables in the model are the concentrations of phosphorylation states of the T cell receptor complex and the phosphatase SHP-1 in the cell.
arxiv
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrine [PDF]
, 1954 P R Kind, E. J. King
openalex +1 more source
Advanced Biology, EarlyView.In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu +12 more
wiley +1 more source