Results 231 to 240 of about 1,127,331 (318)

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

open access: yesAdvanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen   +9 more
wiley   +1 more source

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

open access: yesAdvanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin   +7 more
wiley   +1 more source

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor. [PDF]

open access: yesProc Natl Acad Sci U S A
Husremović T   +24 more
europepmc   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

open access: yesAdvanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu   +9 more
wiley   +1 more source

Age, inflammation, alkaline phosphatase, and coronary artery calcification in firefighters. [PDF]

open access: yesBMC Cardiovasc Disord
Li M   +9 more
europepmc   +1 more source

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