Results 241 to 250 of about 1,202,348 (359)

Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase

Dariia Yehorova, Nikolas Alansson, Ruidan Shen, Joshua Denson, Michael Robinson, Valeria A. Risso, Nuria Ramirez Molina, J. Patrick Loria, Eric A. Gaucher, Jose M. Sanchez-Ruiz, Alvan C. Hengge, Sean Johnson, Shina Caroline Lynn Kamerlin   +12 more
openalex   +1 more source

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Watching Alkaline Phosphatase Catalysis Through Its Vibrational Fingerprint. [PDF]

Biology (Basel)
Tamagnini M, Jiang H, Klivansky L, Bustamante C, Lanzara A.   +4 more
europepmc   +1 more source

PS.99 Investigating phosphoprotein phosphatase signaling using a targeting peptide

openalex   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

The relationship between serum total alkaline phosphatase and risk of osteoporosis: a cross-sectional study. [PDF]

Front Endocrinol (Lausanne)
Chen Y, Zhang Y, Nie M.
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Alkaline Phosphatase Activity in Serum as Indicator for Skeletal Maturity in Assamese Population - An Ex-Vivo Study.

J Pharm Bioallied Sci
Bhattacharjee R, Baruah N, Bora M, Khan RUA, Das SDC.   +4 more
europepmc   +1 more source

Genetic Encoding of Pentafluorophosphato-Phenylalanine Provides PF₅-Proteins as Phosphoprotein Mimetics. [PDF]

Angew Chem Int Ed Engl
Ambros AM, Qianzhu H, Tiemann M, Habel E, Denzinger K, Zupan H, Accorsi M, Keller BG, Wolber G, Huber T, Rademann J.   +10 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source