Results 61 to 70 of about 1,424,154 (388)
Dynamics of Bone Trap-5b Level in Patients with Bone Metastases of Renal Cell Cancer at Combined Treatment [PDF]
, 2017 The objective of this study was to determine the sensitivity of tartrate-resistant acid phosphatase (Bone TRAP-5b) for early detection of bone metastases (BM) and to investigate the efficacy of bisphosphonates (BF) (zolendronic acid-ZA) in prevention of ...
Boichuk, S. (Serhiy) +3 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.
Genes & Development, 1993 The retinoblastoma protein (p110RB) interacts with many cellular proteins in complexes potentially important for its growth-suppressing function. We have developed and used an improved version of the yeast two-hybrid system to isolate human cDNAs ...
T. Durfee +7 more
semanticscholar +1 more source
Molecular Pathology, 2002 Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Mystery surrounds the precise functional role of these molecular facilitators, despite much research. Yet, paradoxically, human APs have had considerable impact as tools of clinical investigation and intervention.
H, Bull +4 more
openaire +2 more sources
Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity [PDF]
British Journal of Cancer, 2020 Phosphatases of regenerating liver (PRL1-3) are among the most oncogenic protein phosphatases but their mechanism of action is poorly understood. Multiple substrates have been proposed as well as a non-catalytic function regulating magnesium transport. Our recent identification of a catalytically inactive PRL mutant that retains oncogenicity in a mouse
Kalle Gehring, Hiroaki Miki
openaire +3 more sources
A study of the root surface phosphatase activities of three species of higher plants: Juncus effusus, Phragnutes australis, and Typha latifolia [PDF]
, 1993 The aim of this project was to investigate a possible link between environmental phosphorus status and the root surface phosphatase activities of three species of emergent macrophytes, with a view to assessing their potential for use as "biondicators ...
Luff, Heather
core
Mass Spectrometry-based Methods for Phosphorylation Site Mapping of Hyperphosphorylated Proteins Applied to Net1, a Regulator of Exit from Mitosis in Yeast [PDF]
, 2002 Prior to anaphase in Saccharomyces cerevisiae, Cdc14 protein phosphatase is sequestered within the nucleolus and inhibited by Net1, a component of the RENT complex in budding yeast. During anaphase the RENT complex disassembles, allowing Cdc14 to migrate
Annan, Roland S. +5 more
core +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B
Toxins, 2020 The Cytolethal Distending Toxin (CDT) is produced by many Gram-negative pathogenic bacteria responsible for major foodborne diseases worldwide. CDT induces DNA damage and cell cycle arrest in host-cells, eventually leading to senescence or apoptosis ...
Benoît J. Pons +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Despite the initial benefit from treating ERBB2-positive breast cancer with tyrosine kinase inhibitor lapatinib, resistance develops inevitably. Since the expression of protein tyrosine phosphatase receptor-type O (PTPRO), a member of the R3 subfamily of
Hongmei Dong +14 more
doaj +1 more source