Results 61 to 70 of about 1,206,748 (358)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Phylogenomic study of Burkholderia glathei-like organisms, proposal of 13 novel Burkholderia species and emended descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae [PDF]

, 2016
Partial gyrB gene sequence analysis of 17 isolates from human and environmental sources revealed 13 clusters of strains and identified them as Burkholderia glathei Glade (BGC) bacteria.
Cooper, Vaughn S, De Brandt, Evie, Meier-Kolthoff, Jan P, Peeters, Charlotte, Vandamme, Peter, Verheyde, Bart   +5 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Temporal Control over Transient Chemical Systems using Structurally Diverse Chemical Fuels [PDF]

, 2017
The next generation of adaptive, intelligent chemical systems will rely on a continuous supply of energy to maintain the functional state. Such systems will require chemical methodology that provides precise control over the energy dissipation process ...
Aida, Alberts, Angulo-Pachon, Anslyn, Barford, Beer, Boekhoven, Boekhoven, Bonomi, Bunz, Burnstock, Busseron, Cekic, Cheng, Cheng, Coleman, Collins, Cruz-Campa, Dambenieks, Debnath, della Sala, Desai, Dhiman, Epstein, Fanlo-Virgós, Fialkowski, Fletcher, Gale, Grzybowski, Grzybowski, Grzybowski, Hess, Heuser, Hoffmann, Ikegami, Ito, Kakugo, Karsenti, Kitamura, Klajn, Klajn, Kostereli, Krabbenborg, Kumar, Kumar, Kumar, Kundu, Lagzi, Le Saux, Li, Liu, Lu, Maeda, Maeda, Maiti, Mann, Mattia, Mohammed, Molnar, Palacci, Pappas, Pappas, Pezzato, Pezzato, Pezzato, Pieters, Pieters, Ragazzon, Rikken, Rogers, Saha, Sanchez, Sasaki, Scarso, Semenov, Shinohara, Soejima, Stuart, Tu, Valeur, Walde, Wang, Warren, Whitesides, Whitesides, Wilson, Wollman, Wood, Wu, Yashin, Zhao   +90 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica

Frontiers in Cellular and Infection Microbiology, 2019
Phosphatidylinositol (PtdIns) metabolism is indispensable in eukaryotes. Phosphoinositides (PIs) are phosphorylated derivatives of PtdIns and consist of seven species generated by reversible phosphorylation of the inositol moieties at the positions 3, 4,
Kumiko Nakada-Tsukui, Natsuki Watanabe, Natsuki Watanabe, Tomohiko Maehama, Tomoyoshi Nozaki   +4 more
doaj   +1 more source

Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model [PDF]

, 2010
Keeping in view the ever increasing problem of drug resistance and affordability of the antimalarial drugs by the poor mass, herbal medicines can become an important and alternative sustainable strategy for malaria treatment.
Chinmoy Karjee, Dipankar Singha, Guruprasad Mandal, Manoj Das, Niladri Sekhar Bhunia, Sajal Ray, Sanat Biswas, Shyamal Das Gupta, Sreemayee Sarkar, Sudipta Chakraborty, Suman Mukherjee, Swapna Chhetri   +11 more
core   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Frontiers in Cell and Developmental Biology, 2018
Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and ...
Niccolo Pengo, Krisna Prak, Joana R. Costa, Christin Luft, Alexander Agrotis, Jamie Freeman, Christina A. Gewinner, A. W. Edith Chan, David L. Selwood, Janos Kriston-Vizi, Robin Ketteler   +10 more
doaj   +1 more source