Results 61 to 70 of about 1,127,331 (318)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

A study of the root surface phosphatase activities of three species of higher plants: Juncus effusus, Phragnutes australis, and Typha latifolia [PDF]

, 1993
The aim of this project was to investigate a possible link between environmental phosphorus status and the root surface phosphatase activities of three species of emergent macrophytes, with a view to assessing their potential for use as "biondicators ...
Luff, Heather
core  

Mass Spectrometry-based Methods for Phosphorylation Site Mapping of Hyperphosphorylated Proteins Applied to Net1, a Regulator of Exit from Mitosis in Yeast [PDF]

, 2002
Prior to anaphase in Saccharomyces cerevisiae, Cdc14 protein phosphatase is sequestered within the nucleolus and inhibited by Net1, a component of the RENT complex in budding yeast. During anaphase the RENT complex disassembles, allowing Cdc14 to migrate
Annan, Roland S., Carr, Steven A., Chen, Susan Loughery, Deshaies, Raymond J., Huddleston, Michael J., Shou, Wenying   +5 more
core   +1 more source

Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

Toxins, 2020
The Cytolethal Distending Toxin (CDT) is produced by many Gram-negative pathogenic bacteria responsible for major foodborne diseases worldwide. CDT induces DNA damage and cell cycle arrest in host-cells, eventually leading to senescence or apoptosis ...
Benoît J. Pons, Nicolas Loiseau, Saleha Hashim, Soraya Tadrist, Gladys Mirey, Julien Vignard   +5 more
doaj   +1 more source

Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance

Frontiers in Pharmacology, 2022
Despite the initial benefit from treating ERBB2-positive breast cancer with tyrosine kinase inhibitor lapatinib, resistance develops inevitably. Since the expression of protein tyrosine phosphatase receptor-type O (PTPRO), a member of the R3 subfamily of
Hongmei Dong, Liang Du, Liang Du, Liang Du, Songwang Cai, Wan Lin, Chaoying Chen, Chaoying Chen, Matthew Still, Zhimeng Yao, Robert P. Coppes, Yunlong Pan, Dianzheng Zhang, Shegan Gao, Hao Zhang   +14 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The Study of Serum Prostate Specific Antigen and Phosphatase Isoenzymes Activity as Diagnostic Parameters in Patients with Prostate Cancer in Nigeria [PDF]

, 2004
Serum activities of Acid Phosphatase (ACP) and Prostatic Acid Phosphatase (PAP) are still employed in most hospitals in Nigeria for the diagnosis of prostate cancer, because of lack of resources for prostate specific antigen (PSA) assay.
Azukaego Thomas Hughs, Mokogwu, Chidi Uzoma, Igwe, Chidiebere Ikechukwu, Ikaraoha, Gilbert Obiora, Nwobu, Jaye Olasumbo, Ogunlewe, Livinus Ariri Donatus, Duru   +5 more
core  

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands [PDF]

, 2010
Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes of the mammalian host. We show that sporozoite latency is an active
Anat Caspi, Balagopal, Beatriz M.A. Fontoura, Boyce, Boyd, Bruña-Romero, Chakraborty, Chakraborty, Christian Doerig, Clare Fennell, Coppi, Dar, David S. Roos, Elizabeth A. Winzeler, Fennell, Ferreira da Silva, Florens, Gantt, Janse, Kaiser, Kappe, Kebaier, Kedersha, Khater, Lasonder, Le Roch, Lisa Ranford-Cartwright, Mair, Meis, Min Zhang, Mota, Mueller, Narasimhan, Pascale Gueirard, Paton, Porter, Proud, Ramanavelan Sakthivel, Renu Tuteja, Robert Ménard, Ruth S. Nussenzweig, Sherman, Stephan Meister, Sullivan, Sullivan, Thompson, Tsuji, Tuteja, Van Der Kelen, Vanderberg, Vervenne, Victor Nussenzweig, Ward, William J. Sullivan, Yamauchi, Yoshida, Yoshida, Zhou   +57 more
core   +2 more sources

Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned?

Frontiers in Chemistry, 2019
Phosphoesterases hydrolyze the phosphorus oxygen bond of phosphomono-, di- or triesters and are involved in various important biological processes. Carboxylate and/or hydroxido-bridged dizinc(II) sites are a widespread structural motif in this enzyme ...
Andrea Erxleben
doaj   +1 more source