Results 61 to 70 of about 854,382 (304)

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

eLife, 2019
Many eukaryotic proteins regulating phosphate (Pi) homeostasis contain SPX domains that are receptors for inositol pyrophosphates (PP-InsP), suggesting that PP-InsPs may regulate Pi homeostasis.
Jinsheng Zhu, Kelvin Lau, Robert Puschmann, Robert K Harmel, Youjun Zhang, Verena Pries, Philipp Gaugler, Larissa Broger, Amit K Dutta, Henning J Jessen, Gabriel Schaaf, Alisdair R Fernie, Ludwig A Hothorn, Dorothea Fiedler, Michael Hothorn   +14 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway [PDF]

, 2012
Protein phosphatases play a key role in balancing the cellular responses to the transforming growth factor-beta (TGF beta) signals. Several protein phosphatases have been attributed roles in the regulation of the TGF beta pathway. Among these.
Yong, Weidong, Bruce, David L., Macartney, Thomas, Shou, Weinian, Sapkota, Gopal P.   +4 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Filament structure and phosphatase activity in the Rivulariaceae [PDF]

, 1989
A study was carried out on phosphatase activity, phosphate uptake and its relationship to hair formation in the Rivulariaceae. The Rivulariaceae was chosen as it is a widespread taxon, where hair formation is a common occurrence, and previous studies ...
Grainger, Stewart L.J.
core  

A unique kelch domain phosphatase in plasmodium regulates ookinete morphology, motility and invasion [PDF]

, 2012
Signalling through post-translational modification (PTM) of proteins is a process central to cell homeostasis, development and responses to external stimuli.
Heli J. Vaikkinen (137832), Nisha Philip (137829), Laurence Tetley, Tetley, L., Waters, A.P., Vaikkinen, Heli J, Tetley, Laurence, Waters, Andrew P., Nisha Philip, Vaikkinen, H.J., Andrew P. Waters (15293), Laurence Tetley (37791), Heli J Vaikkinen, Philip, N., Philip, Nisha, Andrew P Waters   +15 more
core   +1 more source

Inducible degradation-coupled phosphoproteomics identifies PP2ARts1 as a novel eisosome regulator

Frontiers in Cell and Developmental Biology
IntroductionReversible protein phosphorylation is an abundant post-translational modification dynamically regulated by opposing kinases and phosphatases.
Andrew G. DeMarco, Marcella G. Dibble, Mark C. Hall, Mark C. Hall, Mark C. Hall, Mark C. Hall   +5 more
doaj   +1 more source

Maize-soybean intercropping facilitates chemical and microbial transformations of phosphorus fractions in a calcareous soil

Frontiers in Microbiology, 2022
Intercropping often substantially increases phosphorus (P) availability to plants compared with monocropping, which could be an effective strategy for soil legacy P recovery and agricultural production.
Jin Liu, Yang Li, Chaoqun Han, Dongling Yang, Jianjun Yang, Barbara J. Cade-Menun, Yuanquan Chen, Peng Sui   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Surface phosphatase activity of peltigera and cladonia lichens [PDF]

, 1994
This study examines the effects of environmental factors on the surface phosphatase activities of the lichens Peltigera canina (L.) Willd., P. praetextata (Flōrke. ex Sommerf) Vain, and Cladonia arbuscula (Wallr.) Rabenh. Four plants of each species were
Stevenson, Paul A.R.J.
core