Results 51 to 60 of about 877,235 (257)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Inorganic Phosphate Export by the Retrovirus Receptor XPR1 in Metazoans
Cell Reports, 2013 Inorganic phosphate uptake is a universal function accomplished by transporters that are present across the living world. In contrast, no phosphate exporter has ever been identified in metazoans. Here, we show that depletion of XPR1, a multipass membrane
Donatella Giovannini +4 more
doaj +1 more source
In vivo mutational characterization of DndE involved in DNA phosphorothioate modification. [PDF]
PLoS ONE, 2014 DNA phosphorothioate (PT) modification is a recently identified epigenetic modification that occurs in the sugar-phosphate backbone of prokaryotic DNA. Previous studies have demonstrated that DNA PT modification is governed by the five DndABCDE proteins ...
Chongde Lai +10 more
doaj +1 more source
The Characterization and Identification of Ceramide‐1‐Phosphate Binding Proteins
The FASEB Journal, 2012 The activation of cytosolic phospholipase A2 α (cPLA2α) has been implicated in atherosclerosis and cerebral ischemia in previous animal models. The sphingolipid metabolite ceramide‐1‐phosphate (C1P) is known to specifically regulate the activation of cPLA2α and has been shown to increase enzymatic activity 5–10 fold through increased membrane residence.
Katherine E Ward, Robert V Stahelin
openaire +1 more source
The Role of First and Second Shell Interactions in Phosphate Binding Proteins [PDF]
Biophysical Journal, 2013 The phosphate anion is involved in a wide range of processes ranging from cell signaling to energy storage in cells. It can interact with proteins in different modes, where its interactions range from being covalently bound to the protein to coordinating metal sites in enzymes.
Gruber, Mathias +3 more
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Life Science Alliance, 2018 Combination of in vitro and in vivo data show that RNA sequence influences Staufen target recognition and that protein–RNA base contacts are required for Staufen function in Drosophila .
Daniela Lazzaretti +6 more
doaj +1 more source
Molecules, 2022 Pyridoxal 5′-phosphate (PLP) is the active form of vitamin B6, but it is highly reactive and poisonous in its free form. YggS is a PLP-binding protein found in bacteria and humans that mediates PLP homeostasis by delivering PLP to target enzymes or by ...
Shanru He +10 more
doaj +1 more source
Accelerated Molecular Dynamics Simulations of Phosphate Binding Proteins [PDF]
Biophysical Journal, 2016 Phosphorous, an essential element for life, is used in the agriculture for fertilizing and is necessary for sustaining the global food supply. Unfortunately it is a limited resource, and some estimates predict depletion within this century. To avoid future food scarcity it is crucial to recover the lost phosphorous.
openaire +1 more source