Results 71 to 80 of about 1,283,777 (223)
Substrate Induced Structural and Dynamics Changes in Human Phosphomevalonate Iinase and Implications for Mechanism [PDF]
, 2009 Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans.
Cai, Sheng +7 more
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]
, 1993 The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico +6 more
core
Analysis of First and Second Shell Interactions in Phosphate-Binding Proteins [PDF]
Biophysical Journal, 2012 The phosphate anion is involved a wide range of processes ranging from cell signaling to energy storage in cells1. It can interact with proteins in different modes, where its interactions range from being covalently bound to the protein to coordinating metal sites in enzymes2.
Greisen, Per Jr., Hélix-Nielsen, Claus
openaire +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The binding of dyestuffs by proteins [PDF]
, 1950 Thesis (M.A.)--Boston ...
Scully, Margaret A
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Biomolecules, 2020 Neuronal calcium sensors are a family of N-terminally myristoylated membrane-binding proteins possessing a different intracellular localization and thereby targeting unique signaling partner(s).
Viktoriia E. Baksheeva +11 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionSevere equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans.
Christiane L. Schnabel +11 more
doaj +1 more source
The Characterization and Identification of Ceramide‐1‐Phosphate Binding Proteins
The FASEB Journal, 2012 The activation of cytosolic phospholipase A2 α (cPLA2α) has been implicated in atherosclerosis and cerebral ischemia in previous animal models. The sphingolipid metabolite ceramide‐1‐phosphate (C1P) is known to specifically regulate the activation of cPLA2α and has been shown to increase enzymatic activity 5–10 fold through increased membrane residence.
Katherine E Ward, Robert V Stahelin
openaire +1 more source