Results 91 to 100 of about 582,852 (293)

Regression coefficients of linear regression analysis of phosphate binder prescription and log-transformed dp-ucMGP levels in 113 patients with end-stage renal disease on dialysis.

, 2018
Regression coefficients of linear regression analysis of phosphate binder prescription and log-transformed dp-ucMGP levels in 113 patients with end-stage renal disease on dialysis.
Thijs T. Jansz (5703437), Brigit C. van Jaarsveld (5703443), Aegida Neradova (5703440), Adriana J. van Ballegooijen (451317), Marianne C. Verhaar (137865), Marc G. Vervloet (829815), Leon J. Schurgers (123737)   +6 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Direct, indirect, and NMA estimates of calcium with 95% credible intervals and GRADE assessments from each pairwise comparison within the phosphate-binder network.

, 2017
Direct, indirect, and NMA estimates of calcium with 95% credible intervals and GRADE assessments from each pairwise comparison within the phosphate-binder network.
Alfonso Iorio (3215415), Jason W. Busse (34544), Nigar Sekercioglu (3215418), Lehana Thabane (17078), Noori Akhtar-Danesh (68830), Luciane Cruz Lopes (521867), Argie Angeliki Veroniki (3804550), Gordon H. Guyatt (34547)   +7 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Serum Phosphorus and Pill Burden Among Hemodialysis Patients Prescribed Sucroferric Oxyhydroxide: One-Year Follow-Up on a Contemporary Cohort

International Journal of Nephrology and Renovascular Disease, 2022
Jessica B Kendrick,1 Meijiao Zhou,2 Linda H Ficociello,2 Vidhya Parameswaran,2 Claudy Mullon,2 Michael S Anger,2,3 Daniel W Coyne4 1University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 2Fresenius Medical Care Global Medical Office, Waltham ...
Kendrick JB, Zhou M, Ficociello LH, Parameswaran V, Mullon C, Anger MS, Coyne DW   +6 more
doaj  

Effect of the phosphate binder sucroferric oxyhydroxide in dialysis patients on endogenous calciprotein particles, inflammation, and vascular cells. [PDF]

Nephrol Dial Transplant, 2023
Thiem U, Hewitson TD, Toussaint ND, Holt SG, Haller MC, Pasch A, Cejka D, Smith ER.   +7 more
europepmc   +1 more source

Direct, indirect, and NMA estimates of parathyroid hormone with 95% credible intervals and GRADE assessments from each pairwise comparison within the phosphate-binder network.

, 2017
Direct, indirect, and NMA estimates of parathyroid hormone with 95% credible intervals and GRADE assessments from each pairwise comparison within the phosphate-binder network.
Alfonso Iorio (3215415), Jason W. Busse (34544), Nigar Sekercioglu (3215418), Lehana Thabane (17078), Noori Akhtar-Danesh (68830), Luciane Cruz Lopes (521867), Argie Angeliki Veroniki (3804550), Gordon H. Guyatt (34547)   +7 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Serum phosphate level at initiation of dialysis is associated with all-cause mortality: a multicenter prospective cohort study

Renal Failure, 2018
Introduction: As glomerular filtration rate (GFR) decreases, serum phosphate level increases. Previous reports indicated that serum phosphate level was associated with mortality in patients on dialysis.
Akiko Owaki, Daijo Inaguma, Isao Aoyama, Shinichiro Inaba, Shigehisa Koide, Eri Ito, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa, AICOPP group   +10 more
doaj   +1 more source

Utility of Phosphate Binder Equivalent Dose Concept. [PDF]

J Am Soc Nephrol, 2021
Kulkarni M.
europepmc   +1 more source