Results 1 to 10 of about 261,167 (271)

First-principles study of high conductance DNA sequencing with carbon nanotube electrodes [PDF]

, 2011
Rapid and cost-effective DNA sequencing at the single nucleotide level might be achieved by measuring a transverse electronic current as single-stranded DNA is pulled through a nano-sized pore.
C. D. Pemmaraju, H. Peng, I. Rungger, S. Sanvito, U. Schwingenschlögl, V. Meunier, X. Chen   +6 more
core   +2 more sources

Evaluation of alternative solvents in common amide coupling reactions : replacement of dichloromethane and N,N-dimethylformamide [PDF]

, 2013
A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N ...
Abdelmoty, Al-Zoubi, Albericio, Albericio, Alfonsi, Allan J. B. Watson, Antonucci, Arnold, Arnold, Benoiton, Bian, Bode, Carpino, Charville, Constable, Cooper, Coste, Craig Jamieson, Cue, Donna S. MacMillan, El-Faham, El-Faham, El-Faham, Elmore, Escher, Fischbach, Funabashi, Ghosh, Gunanathan, Han, Helen F. Sneddon, Henderson, Humphrey, Ishihara, Ishihara, Jane Murray, Junkers, Junkers, Junkers, Junkers, Junkers, Jursie, Klausner, Li, MacMillan, Maki, Marcelli, Mitchell, Montalbetti, Nielsen, Nordstrøm, Pattabiraman, Perreux, Roughley, Simonovic, Starkov, Subirós-Funosas, Tang, Valeur, Watanabe, Watson, Wissmann   +61 more
core   +1 more source

Computationally Assisted Design of Polarizing Agents for Dynamic Nuclear Polarization Enhanced NMR: The AsymPol Family

Journal of the American Chemical Society, 2018
We introduce a new family of highly efficient polarizing agents for dynamic nuclear polarization (DNP)-enhanced nuclear magnetic resonance (NMR) applications, composed of asymmetric bis-nitroxides, in which a piperidine-based radical and a pyrrolinoxyl ...
F. Mentink-Vigier, I. Marín-Montesinos, A. Jagtap, Thomas Halbritter, J. van Tol, S. Hediger, Daniel Lee, S. Sigurdsson, Gaël De Paëpe   +8 more
semanticscholar   +1 more source

Reversible zwitterionic coordination enables rapid, high-yield, and high-purity isolation of extracellular vesicles from biofluids

Science Advances, 2023
Extracellular vesicles (EVs) hold great clinical value as promising diagnostic biomarkers and therapeutic agents. This field, however, is hindered by technical challenges in the isolation of EVs from biofluids for downstream purposes.
Qiang Li, Zhaowei Zhang, Fengchao Wang, Xiang Wang, Saisong Zhan, Xiaoqing Yang, Chen Xu, Dingbin Liu   +7 more
semanticscholar   +1 more source

The differential cardiotoxicity effects and molecular mechanisms induced by two emerging organophosphorus flame retardants (EHDPP and DPHP) with similar parent structures in zebrafish

Environmental Chemistry and Ecotoxicology
Herein, we systematically compared the cardiotoxicity effects of two structurally similar organophosphate flame retardants (OPFRs; EHDPP and its major metabolite DPHP) using zebrafishi as a model organism.
Miaocui Xi, Xue Bai, Lu Fang, Xuedong Wang, Jin Yan, Qiuhui Qian, Zejun Wang, Huili Wang   +7 more
doaj   +1 more source

The synthesis and characterization of polypeptide-adriamycin conjugates and its complexes with adriamycin. Part I [PDF]

, 1985
Poly(α-l-glutamic acid) (PGA) was grafted with amino acid and oligopeptide spacers up to 5 amino acids with the use of N,N'-carbonyldiimidazole and 2,3-dihydro-1,2-benz-isothiazole-3-on-1, 1-dioxide (saccharin) as an additive, and these polypeptides were
Eenink, M.J.D., Feijen, J., Heeswijk, W.A.R., Hoes, C.J.T., Potman, W., Stoffer, T.   +5 more
core   +2 more sources

A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds [PDF]

, 2010
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses.
AJ Wright, Anton Bunschoten, B Postma, B Postma, BO Gerber, Carla J. C. de Haas, CE Stotz, DE Epps van, F Blanco, H Lee, J Cavanagh, JH Ippel, JJ Chen, Johan Kemmink, Johannes H. Ippel, John A. W. Kruijtzer, KE Veldkamp, LM Proctor, Louris Feitsma, M Allegretti, M Farzan, PJ Haas, PN Monk, RF Guo, Rob M. J. Liskamp, TS Haque, ZG Chen   +26 more
core   +1 more source

Catalytic activation of glycosyl phosphates for stereoselective coupling reactions

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Despite their dominant role as electrophiles in biosynthetic pathways promoted by enzymes, organic phosphates are rarely employed in laboratory synthesis, because phosphates are generally very poor leaving groups.
Samuel M. Levi, Qiuhan Li, Andreas R. Rötheli, E. Jacobsen   +3 more
semanticscholar   +1 more source

Functionalization Strategies of Chitosan-Based Scaffolds with Growth Factors for Bone Regeneration: A Systematic Review

Marine Drugs
Bioactive agents can stimulate osteogenesis, angiogenesis, and cell proliferation; therefore, their application in bone regeneration offers significant therapeutic potential.
Jan Kiryk, Mateusz Michalak, Zuzanna Majchrzak, Marzena Laszczyńska, Sylwia Kiryk, Sylwia Szotek, Hanna Gerber, Izabela Nawrot-Hadzik, Jacek Matys, Maciej Dobrzyński   +9 more
doaj   +1 more source

Remnants of an ancient metabolism without phosphate [PDF]

, 2017
Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E., Hartman, Hyman, Segrè, Daniel, Smith, Temple F.   +3 more
core   +1 more source