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Recent findings in phosphate homeostasis

Current Opinion in Nephrology & Hypertension, 2005
We summarize the most recent findings on the proteins that interact with sodium/inorganic phosphate (Na/Pi) cotransporters, the factors that regulate Pi homeostasis and their role in pathology.Studies in animal models and cell lines identified proteins mandatory to correct trafficking of the kidney-specific Na/Pi cotransporter NPT2a and its control by ...
Dominique, Prié   +3 more
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Phosphate homeostasis

2015
Abstract Inorganic phosphate ions (H2PO4−/ HPO42−) (abbreviated as Pi) are involved in formation of bone and generation of high-energy bonds (e.g. ATP), metabolic pathways, and regulation of cellular functions. In addition, Pi is a component of biological membranes and nucleic acids.
Heini Murer   +2 more
openaire   +1 more source

Phosphate and Acid-Base Homeostasis

1980
Both because of its properties as a buffer and its function as a major intracellular anion, phosphate plays a pivotal role in the maintenance of acid-base homeostasis. This review is concerned with the impact of phosphate on three interrelated aspects of acid-base physiology and pathophysiology.
N A, Kurtzman, J A, Arruda
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Phosphate Homeostasis

Comprehensive Physiology, 1991
Abstract The sections in this article are: Phosphate Regulation Plasma Phosphate Concentration Renal Handling of Phosphate ...
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Phosphate Homeostasis and Disorders of Phosphate Metabolism

Current Pediatric Reviews
Abstract: Phosphate is indispensable for human life and evolutionary changes over several millions of years have established tightly regulated mechanisms to ensure phosphate homeostasis. In this process, calcium and phosphate metabolism have come to be intricately linked together.
Nandhini Lakshmana Perumal   +1 more
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FGF23 and disorders of phosphate homeostasis

Cytokine & Growth Factor Reviews, 2005
It is well known that fibroblast growth factor (FGF) family members are associated with embryonic development and are critical for basic metabolic functions. This review will focus upon fibroblast growth factor-23 (FGF23) and its roles in disorders associated with phosphate handling.
Xijie, Yu, Kenneth E, White
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Homeostasis of inorganic phosphate: An introductory review

Calcified Tissue Research, 1975
Body phosphorus is to the greatest extent (80–90%) in the bone mineral as calcium phosphate. The rest is in the soft tissues and in the blood. In the latter, it is either in the red cells mostly as esters and phospholipids, or in the plasma as esters, lipids and inorganic phosphate. Only the homeostasis of inorganic phosphate will be considered in this
H, Fleisch, J P, Bonjour, U, Troehler
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NPT2a — The Key to Phosphate Homeostasis

New England Journal of Medicine, 2002
Phosphate leads two lives — an ancient intracellular one and a more recent extracellular one. Inside cells, phosphate has a structural role in nucleic acids and phospholipids, forms high-energy est...
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Phosphate and Mineral Homeostasis

1986
I. Special Presentations.- High Energy Phosphate, Phospholipids and Calcium in Ischemic Renal Tubular Cell Injury.- Calcium, Cell Function and Cell Death.- Primary Hyperparathyroidism (PHP) Revisited.- II. Renal Handling of Phosphate.- Mechanisms of Ion Transport Regulation by Parathyroid Hormone: cAMP/Ca2+/Calmodulin and Phospholipid Dependent ...
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Phosphatonins and the Regulation of Phosphate Homeostasis

Annual Review of Physiology, 2007
Inorganic phosphate (Pi) is required for energy metabolism, nucleic acid synthesis, bone mineralization, and cell signaling. The activity of cell-surface sodium-phosphate (Na+-Pi) cotransporters mediates the uptake of Pi from the extracellular environment.
Theresa, Berndt, Rajiv, Kumar
openaire   +2 more sources

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